Entity Details

Primary name MMP15_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51511
EntryNameMMP15_HUMAN
FullNameMatrix metalloproteinase-15
TaxID9606
Evidenceevidence at protein level
Length669
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMMP15

GO terms

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GOName
GO:0004222 metalloendopeptidase activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0008047 enzyme activator activity
GO:0008270 zinc ion binding
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0032355 response to estradiol
GO:0035987 endodermal cell differentiation
GO:0070006 metalloaminopeptidase activity

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminalDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028729 Matrix metalloproteinase-15FamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MMP15_HUMANPROC_HUMANIntAct15248212 details
MMP15_HUMANLRP1_HUMANHPRD14645246 details