Entity Details

Primary name MECP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51608
EntryNameMECP2_HUMAN
FullNameMethyl-CpG-binding protein 2
TaxID9606
Evidenceevidence at protein level
Length486
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMECP2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000792 heterochromatin
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0001964 startle response
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006020 inositol metabolic process
GO:0006342 chromatin silencing
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006541 glutamine metabolic process
GO:0006576 cellular biogenic amine metabolic process
GO:0007052 mitotic spindle organization
GO:0007416 synapse assembly
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0007616 long-term memory
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0008211 glucocorticoid metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008327 methyl-CpG binding
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009791 post-embryonic development
GO:0010385 double-stranded methylated DNA binding
GO:0010629 negative regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016358 dendrite development
GO:0016525 negative regulation of angiogenesis
GO:0016571 histone methylation
GO:0016573 histone acetylation
GO:0019230 proprioception
GO:0019233 sensory perception of pain
GO:0019904 protein domain specific binding
GO:0021549 cerebellum development
GO:0021591 ventricular system development
GO:0032048 cardiolipin metabolic process
GO:0035176 social behavior
GO:0035197 siRNA binding
GO:0042551 neuron maturation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046470 phosphatidylcholine metabolic process
GO:0047485 protein N-terminus binding
GO:0051151 negative regulation of smooth muscle cell differentiation
GO:0051707 response to other organism
GO:0060079 excitatory postsynaptic potential
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060291 long-term synaptic potentiation
GO:0090063 positive regulation of microtubule nucleation
GO:0098794 postsynapse
GO:1900114 positive regulation of histone H3-K9 trimethylation
GO:1905643 positive regulation of DNA methylation
GO:1990841 promoter-specific chromatin binding
GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001739 Methyl-CpG DNA bindingDomainDomain
IPR016177 DNA-binding domain superfamilyFamilyHomologous superfamily
IPR017353 Methyl-CpG binding protein MeCP2FamilyFamily

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
MECP2_HUMANSMCA2_HUMANBioGRID, HPRD, IntAct15696166 20093853 details
MECP2_HUMANHIPK2_HUMANBioGRID, MINT19820693 details
MECP2_HUMANSOX18_HUMANBioGRID, IntAct21988832 details
MECP2_HUMANTBL1R_HUMANBioGRID, DIP23770565 28348241 details
MECP2_HUMANSIN3A_HUMANBioGRID, DIP, HPRD10773092 11441023 14593184 15322089 22615490 23770565 9620779 9620804 details
MECP2_HUMANHSPB1_HUMANIntAct32814053 details
MECP2_HUMANAP2B1_HUMANIntAct32814053 details
MECP2_HUMANRASF5_HUMANIntAct32814053 details
MECP2_HUMANAB17C_HUMANIntAct32814053 details
MECP2_HUMANOTU7B_HUMANIntAct32814053 details
MECP2_HUMANOTUB1_HUMANIntAct32814053 details
MECP2_HUMANASB3_HUMANIntAct32814053 details
MECP2_HUMANKLH20_HUMANIntAct32814053 details
MECP2_HUMANRAB38_HUMANIntAct32814053 details
MECP2_HUMANCYFP1_HUMANIntAct32814053 details
MECP2_HUMANDDX20_HUMANIntAct32814053 details
MECP2_HUMANRASF1_HUMANIntAct32814053 details
MECP2_HUMANKAT5_HUMANIntAct32814053 details
MECP2_HUMANIQEC1_HUMANIntAct32814053 details
MECP2_HUMANSTX11_HUMANIntAct32814053 details
MECP2_HUMANPIAS1_HUMANIntAct32814053 details
MECP2_HUMANCSN3_HUMANIntAct32814053 details
MECP2_HUMANRN112_HUMANIntAct32814053 details
MECP2_HUMANBRK1_HUMANIntAct32814053 details
MECP2_HUMANTHIO_HUMANIntAct32814053 details
MECP2_HUMANSMN_HUMANIntAct32814053 details
MECP2_HUMANSNF5_HUMANBioGRID, HPRD, IntAct1569166 15696166 32814053 details
MECP2_HUMANNP1L3_HUMANIntAct32814053 details
MECP2_HUMANMSH5_HUMANIntAct32814053 details
MECP2_HUMANLYN_HUMANIntAct32814053 details
MECP2_HUMANEYA3_HUMANIntAct32814053 details
MECP2_HUMANCTNB1_HUMANIntAct32814053 details
MECP2_HUMANTRI74_HUMANIntAct32814053 details
MECP2_HUMANSPT12_HUMANIntAct32814053 details
MECP2_HUMANKRA81_HUMANIntAct32814053 details
MECP2_HUMANFOXR1_HUMANIntAct32814053 details
MECP2_HUMANTRI69_HUMANIntAct32814053 details
MECP2_HUMANRN183_HUMANIntAct32814053 details
MECP2_HUMANATIF1_HUMANIntAct32814053 details
MECP2_HUMANHUMMR_HUMANIntAct32814053 details
MECP2_HUMANNFL_HUMANIntAct32814053 details
MECP2_HUMANPRPS1_HUMANIntAct32814053 details
MECP2_HUMANWFS1_HUMANIntAct32814053 details
MECP2_HUMANOPTN_HUMANIntAct32814053 details
MECP2_HUMANHD_HUMANIntAct32814053 details
MECP2_HUMANPR40A_HUMANBioGRID, HPRD14618241 9171351 details
MECP2_HUMANHMGB1_HUMANBioGRID, HPRD11748221 details
MECP2_HUMANSKI_HUMANBioGRID, HPRD11441023 details
MECP2_HUMANNCOR1_HUMANBioGRID, HPRD11441023 28348241 details
MECP2_HUMANTF2B_HUMANBioGRID10756192 details
MECP2_HUMANH32_HUMANBioGRID12427740 21278419 details
MECP2_HUMANDNMT1_HUMANBioGRID12473678 details
MECP2_HUMANHDAC1_HUMANBioGRID12473678 14593184 14647463 16331260 details
MECP2_HUMANPR40B_HUMANBioGRID14618241 details
MECP2_HUMANSPI1_HUMANBioGRID14647463 16331260 details
MECP2_HUMANLBR_HUMANBioGRID19331822 details
MECP2_HUMANCDKL5_HUMANBioGRID15917271 details
MECP2_HUMANTYY1_HUMANBioGRID20504995 24981860 details
MECP2_HUMANRNF4_HUMANBioGRID25355316 29180619 details
MECP2_HUMANDNM3L_HUMANBioGRID24952347 details
MECP2_HUMANTBL1X_HUMANBioGRID28348241 details
MECP2_HUMANATRX_HUMANDIP17296936 details
MECP2_HUMANSUH_HUMANBioGRID, MINT16763620 25609649 details
MECP2_HUMANRCOR1_HUMANBioGRID12399542 details
MECP2_HUMANSUV91_HUMANBioGRID12399542 details
MECP2_HUMANSP1_HUMANBioGRID15109260 20385708 details
MECP2_HUMANSMCE1_HUMANBioGRID15696166 details
MECP2_HUMANCBX5_HUMANBioGRID17698499 22615490 details
MECP2_HUMANYBOX1_HUMANBioGRID16251272 22615490 details
MECP2_HUMANSP3_HUMANBioGRID20385708 details
MECP2_HUMANSOX2_HUMANBioGRID20368621 details
MECP2_HUMANTERF2_HUMANBioGRID20811636 details
MECP2_HUMANSMC3_HUMANBioGRID22615490 details
MECP2_HUMANCBX1_HUMANBioGRID22615490 details
MECP2_HUMANCBX3_HUMANBioGRID22615490 34079125 details
MECP2_HUMANH2A2C_HUMANBioGRID21278419 details
MECP2_HUMANH2B2E_HUMANBioGRID21278419 details
MECP2_HUMANH4_HUMANBioGRID21278419 30804502 details