Entity Details

Primary name AQP5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55064
EntryNameAQP5_HUMAN
FullNameAquaporin-5
TaxID9606
Evidenceevidence at protein level
Length265
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesAQP5

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005902 microvillus
GO:0006833 water transport
GO:0009925 basal plasma membrane
GO:0015250 water channel activity
GO:0015670 carbon dioxide transport
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030157 pancreatic juice secretion
GO:0030659 cytoplasmic vesicle membrane
GO:0042476 odontogenesis
GO:0042802 identical protein binding
GO:0046541 saliva secretion
GO:0048593 camera-type eye morphogenesis
GO:0051289 protein homotetramerization
GO:0070062 extracellular exosome
GO:0071476 cellular hypotonic response

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Cytoplasmic vesicle membrane

Domains

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DomainNameCategoryType
IPR000425 Major intrinsic proteinFamilyFamily
IPR022357 Major intrinsic protein, conserved siteSiteConserved site
IPR023271 Aquaporin-likeFamilyHomologous superfamily
IPR023276 Aquaporin 5FamilyFamily
IPR034294 Aquaporin transporterFamilyFamily

Diseases

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Disease IDSourceNameDescription
600231 OMIMKeratoderma, palmoplantar, Bothnian type (PPKB)A dermatological disorder characterized by diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal infections. The disease is caused by variants affecting the gene represented in this entry.