Entity Details

Primary name FOXG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55316
EntryNameFOXG1_HUMAN
FullNameForkhead box protein G1
TaxID9606
Evidenceevidence at protein level
Length489
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesFOXG1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0002052 positive regulation of neuroblast proliferation
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007346 regulation of mitotic cell cycle
GO:0007420 brain development
GO:0007568 aging
GO:0009953 dorsal/ventral pattern formation
GO:0016199 axon midline choice point recognition
GO:0021852 pyramidal neuron migration to cerebral cortex
GO:0042472 inner ear morphogenesis
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048664 neuron fate determination
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR018122 Fork head domain conserved site1SiteConserved site
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613454 OMIMRett syndrome congenital variant (RTTCV)A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements. The disease is caused by variants affecting the gene represented in this entry.