Entity Details

Primary name GSDMD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP57764
EntryNameGSDMD_HUMAN
FullNameGasdermin-D
TaxID9606
Evidenceevidence at protein level
Length484
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesGSDMD

GO terms

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GOName
GO:0001786 phosphatidylserine binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0016021 integral component of membrane
GO:0022829 wide pore channel activity
GO:0032731 positive regulation of interleukin-1 beta production
GO:0035580 specific granule lumen
GO:0035915 pore formation in membrane of other organism
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0046931 pore complex assembly
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051260 protein homooligomerization
GO:0070269 pyroptosis
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0070300 phosphatidic acid binding
GO:0072559 NLRP3 inflammasome complex
GO:1901612 cardiolipin binding
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Inflammasome
Secreted

Domains

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DomainNameCategoryType
IPR007677 GasderminFamilyFamily
IPR040460 Gasdermin, pore forming domainDomainDomain
IPR041263 Gasdermin, PUB domainDomainDomain

Diseases

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