Entity Details

Primary name PHC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78364
EntryNamePHC1_HUMAN
FullNamePolyhomeotic-like protein 1
TaxID9606
Evidenceevidence at protein level
Length1004
SequenceStatuscomplete
DateCreated2002-11-15
DateModified2021-06-02

Ontological Relatives

GenesPHC1

GO terms

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GOName
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0007275 multicellular organism development
GO:0008270 zinc ion binding
GO:0016574 histone ubiquitination
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
GO:0042393 histone binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070317 negative regulation of G0 to G1 transition

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR012313 Zinc finger, FCS-typeDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR038603 FCS-type zinc finger superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615414 OMIMMicrocephaly 11, primary, autosomal recessive (MCPH11)A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. The disease is caused by variants affecting the gene represented in this entry.

Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
PHC1_HUMANHSP7C_HUMANHPRD, IntAct16169070 details
PHC1_HUMANSMBT1_HUMANBioGRID, HPRD, IntAct16189514 details
PHC1_HUMANUBC9_HUMANBioGRID, HPRD, IntAct16189514 details
PHC1_HUMANPHC2_HUMANBioGRID, HPRD, IntAct15563468 16189514 22325352 24981860 28514442 9121482 details
PHC1_HUMANBMI1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt15563468 19636380 20601937 22325352 23523425 24981860 27647897 27705803 28514442 9009205 9121482 9199346 details
PHC1_HUMANPCGF2_HUMANBioGRID, DIP, IntAct, MINT, UniProt19636380 20601937 22325352 23523425 24981860 27705803 28514442 32296183 details
PHC1_HUMANPP1A_HUMANBioGRID, IntAct22321011 details
PHC1_HUMANSDCB2_HUMANBioGRID, IntAct32296183 details
PHC1_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
PHC1_HUMANSMBT2_HUMANBioGRID, IntAct28514442 32296183 details
PHC1_HUMANFAM9A_HUMANBioGRID, IntAct32296183 details
PHC1_HUMANPCGF3_HUMANBioGRID, IntAct24981860 32296183 details
PHC1_HUMANPP1G_HUMANBioGRID23080069 details
PHC1_HUMANPHC1_HUMANBioGRID25416956 details
PHC1_HUMANSIAH1_HUMANBioGRID25416956 details
PHC1_HUMANSP100_HUMANBioGRID25416956 details
PHC1_HUMANSUMO1_HUMANBioGRID25416956 details
PHC1_HUMANPIAS2_HUMANBioGRID25416956 details
PHC1_HUMANZCHC7_HUMANBioGRID25416956 details
PHC1_HUMANTET2_HUMANBioGRID30404004 details
PHC1_HUMANCBX8_HUMANBioGRID, IntAct, MINT17332741 22325352 24981860 26496610 27705803 28514442 details
PHC1_HUMANCBX4_HUMANBioGRID, IntAct, UniProt21282530 22078878 22325352 24981860 26496610 27705803 28514442 9199346 details
PHC1_HUMANRING2_HUMANBioGRID, HPRD, IntAct, MINT12183370 22325352 24981860 26496610 27705803 28514442 details
PHC1_HUMANRING1_HUMANBioGRID, HPRD, IntAct, MINT22325352 24981860 27705803 28514442 9199346 details
PHC1_HUMANSCMH1_HUMANBioGRID, HPRD, IntAct, MINT10653359 22325352 24981860 28514442 details
PHC1_HUMANFXR1_HUMANMINT21653829 details
PHC1_HUMANGEMI_HUMANHPRD14973489 details