Entity Details

Primary name ARGI2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78540
EntryNameARGI2_HUMAN
FullNameArginase-2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length354
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesARG2

GO terms

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GOName
GO:0000050 urea cycle
GO:0001657 ureteric bud development
GO:0002250 adaptive immune response
GO:0002829 negative regulation of type 2 immune response
GO:0004053 arginase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006809 nitric oxide biosynthetic process
GO:0006941 striated muscle contraction
GO:0019547 arginine catabolic process to ornithine
GO:0030145 manganese ion binding
GO:0032651 regulation of interleukin-1 beta production
GO:0032696 negative regulation of interleukin-13 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0045087 innate immune response
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:0071644 negative regulation of chemokine (C-C motif) ligand 4 production
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:1900425 negative regulation of defense response to bacterium
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:2000774 positive regulation of cellular senescence

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR006035 UreohydrolaseFamilyFamily
IPR014033 ArginaseFamilyFamily
IPR020855 Ureohydrolase, manganese-binding siteSiteBinding site
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00125 ArginineDrugbanksmall molecule
DB00129 OrnithineDrugbanksmall molecule
DB03731 S-2-(Boronoethyl)-L-CysteineDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
ARGI2_HUMANSTK11_HUMANBioGRID, MINT25640309 details
ARGI2_HUMANFX4L6_HUMANIntAct32814053 details
ARGI2_HUMANARGI1_HUMANBioGRID, HPRD, IntAct11849441 28514442 details