Entity Details - PICKLE: A Protein InteraCtion KnowLedgebasE

Primary name	NFKB2_HUMAN
Entity type	UniProt
Source	Source Link

Details

Accession	Q00653
EntryName	NFKB2_HUMAN
FullName	Nuclear factor NF-kappa-B p100 subunit
TaxID	9606
Evidence	evidence at protein level
Length	900
SequenceStatus	complete
DateCreated	1993-10-01
DateModified	2021-06-02

Ontological Relatives

Genes

NFKB2

GO terms

Show/Hide Table

GO	Name
GO:0000785	chromatin
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002268	follicular dendritic cell differentiation
GO:0002467	germinal center formation
GO:0003700	DNA-binding transcription factor activity
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription by RNA polymerase II
GO:0007568	aging
GO:0030198	extracellular matrix organization
GO:0032481	positive regulation of type I interferon production
GO:0032496	response to lipopolysaccharide
GO:0033257	Bcl3/NF-kappaB2 complex
GO:0034097	response to cytokine
GO:0038061	NIK/NF-kappaB signaling
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0048511	rhythmic process
GO:0048536	spleen development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1990837	sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table

Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table

Domain	Name	Category	Type
IPR000451	NF-kappa-B/Dorsal	Family	Family
IPR000488	Death domain	Domain	Domain
IPR002110	Ankyrin repeat	Repeat	Repeat
IPR002909	IPT domain	Domain	Domain
IPR008967	p53-like transcription factor, DNA-binding	Family	Homologous superfamily
IPR011029	Death-like domain superfamily	Family	Homologous superfamily
IPR011539	Rel homology domain (RHD), DNA-binding domain	Domain	Domain
IPR013783	Immunoglobulin-like fold	Family	Homologous superfamily
IPR014756	Immunoglobulin E-set	Family	Homologous superfamily
IPR020683	Ankyrin repeat-containing domain	Domain	Domain
IPR030492	Rel homology domain, conserved site	Site	Conserved site
IPR030497	Nuclear factor NF-kappa-B, p100 subunit	Family	Family
IPR032397	Rel homology dimerisation domain	Domain	Domain
IPR033926	NFkappaB IPT domain	Domain	Domain
IPR036770	Ankyrin repeat-containing domain superfamily	Family	Homologous superfamily
IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily	Family	Homologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table

Drug	Name	Source	Type
DB00843	Donepezil	Drugbank	small molecule
DB01296	Glucosamine	Drugbank	small molecule
DB05212	HE3286	Drugbank	small molecule
DB05451	P54	Drugbank	small molecule
DB05464	NOX-700	Drugbank	small molecule
DB05471	SGN-30	Drugbank	biotech
DB05487	Custirsen	Drugbank	small molecule
DB05559	NF-kappaB Decoy	Drugbank	small molecule
DB05767	Andrographolide	Drugbank	small molecule
DB13751	Glycyrrhizic acid	Drugbank	small molecule
DB13961	Fish oil	Drugbank	biotech
DB14059	SC-236	Drugbank	small molecule

Interactions

109 interactions

Interactor	Partner	Sources	Publications	Link
NFKB2_HUMAN	IKBE_HUMAN	BioGRID, HPRD, IntAct	14743216 9315679	details
NFKB2_HUMAN	TF65_HUMAN	BioGRID, HPRD, IntAct	14743216 16009713 16940413 17962807 27609421 29084252 8413211	details
NFKB2_HUMAN	IKKA_HUMAN	BioGRID, HPRD, IntAct	14743216 15140882 16303288 16651533 17563756 18617892	details
NFKB2_HUMAN	NFKB1_HUMAN	BioGRID, HPRD, IntAct, MINT	14743216 15169888 15660126 21988832 25609649 27609421	details
NFKB2_HUMAN	FBW1A_HUMAN	BioGRID, HPRD, MINT	11994270 14676825 15140882 16303288 18617892 22388891 25900982	details
NFKB2_HUMAN	EPS8_HUMAN	BioGRID, IntAct	21988832	details
NFKB2_HUMAN	BCL3_HUMAN	BioGRID, HPRD, IntAct	11707390 14678988 17962807 20558726 20800578 28689659 30833792 8453667	details
NFKB2_HUMAN	IKBZ_HUMAN	BioGRID, IntAct	20211142	details
NFKB2_HUMAN	MEN1_HUMAN	BioGRID, HPRD	11526476	details
NFKB2_HUMAN	SP1_HUMAN	BioGRID	7933095	details
NFKB2_HUMAN	GCR_HUMAN	BioGRID, HPRD	7823959	details
NFKB2_HUMAN	NKRF_HUMAN	BioGRID, HPRD	10562553	details
NFKB2_HUMAN	T22D3_HUMAN	BioGRID, HPRD	11468175	details
NFKB2_HUMAN	PSD11_HUMAN	BioGRID, HPRD	12185077	details
NFKB2_HUMAN	REQU_HUMAN	BioGRID	20460684	details
NFKB2_HUMAN	FBW1B_HUMAN	BioGRID	22017875 25332235 25515538 25900982 28004927	details
NFKB2_HUMAN	REL_HUMAN	BioGRID, HPRD, IntAct	14743216 17962807 26186194 27609421 28514442 8152812 8413211	details
NFKB2_HUMAN	IKBA_HUMAN	BioGRID, HPRD, IntAct	14743216 26186194 26496610 28514442	details
NFKB2_HUMAN	IKBB_HUMAN	BioGRID, HPRD, IntAct	14743216 26186194 28514442	details
NFKB2_HUMAN	AIFM1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HS71L_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	BIP_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	U5S1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HSP7C_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYRC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	MBB1A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	ILF2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	GRP75_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PRP8_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYMC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS5_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS10_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RLA2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	IQGA1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS3_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RPOM_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DNJA1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYIC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS18_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SYEP_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PABP1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	EF1A2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DDX21_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	MATR3_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RT29_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PYR1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	ECHB_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TIM50_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	CLH1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	IKKB_HUMAN	HPRD, IntAct	14743216	details
NFKB2_HUMAN	RS11_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS14_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	FAS_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	GEMI4_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL7_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	ECHA_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBB6_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	CALM2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBB5_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DHX9_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TF3C1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBB4A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	NFKB2_HUMAN	BioGRID, HPRD, IntAct	14743216 17962807 22388891	details
NFKB2_HUMAN	CCAR2_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RLA0L_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	DNJA3_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HNRPU_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL18_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS19_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	UBB_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS8_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HNRPC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	SFPQ_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PARP1_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS4X_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HS90A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	NUCL_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	PRKDC_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBA3C_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBA3D_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL7A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL11_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS3A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RL13_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	HNRPM_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS24_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	H2B1B_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	XRCC5_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	USP9X_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS15A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS16_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RS27_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	TBA1A_HUMAN	IntAct	14743216	details
NFKB2_HUMAN	RELB_HUMAN	BioGRID, HPRD, IntAct	12505990 14678988 14743216 17962807 22388891 22864569 27609421 28514442	details
NFKB2_HUMAN	GTF2I_HUMAN	HPRD, IntAct	14743216	details
NFKB2_HUMAN	SUMO1_HUMAN	MINT	18617892	details
NFKB2_HUMAN	UBC_HUMAN	MINT	18617892	details
NFKB2_HUMAN	M3K14_HUMAN	BioGRID, HPRD, IntAct	11239468 17563756 30833792 31980649	details
NFKB2_HUMAN	FBXW7_HUMAN	BioGRID	14743216 22388891 22864569 25720964 32350066	details
NFKB2_HUMAN	TS101_HUMAN	BioGRID	19542561	details
NFKB2_HUMAN	TNAP3_HUMAN	BioGRID	24008839	details
NFKB2_HUMAN	STAT3_HUMAN	BioGRID	16651533 25771405	details
NFKB2_HUMAN	VDR_HUMAN	BioGRID	26269414	details
NFKB2_HUMAN	ZHX2_HUMAN	BioGRID	30026228	details
NFKB2_HUMAN	IASPP_HUMAN	BioGRID	29743530	details
NFKB2_HUMAN	STF1_HUMAN	HPRD	12917325	details
NFKB2_HUMAN	HDAC4_HUMAN	HPRD	12917325	details
NFKB2_HUMAN	HDAC5_HUMAN	HPRD	12917325	details
NFKB2_HUMAN	SIN3A_HUMAN	HPRD	17962807	details