Entity Details

Primary name PDE1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01064
EntryNamePDE1B_HUMAN
FullNameCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
TaxID9606
Evidenceevidence at protein level
Length536
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPDE1B

GO terms

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GOName
GO:0001505 regulation of neurotransmitter levels
GO:0001975 response to amphetamine
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516 calmodulin binding
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007626 locomotory behavior
GO:0008542 visual learning
GO:0030224 monocyte differentiation
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0042053 regulation of dopamine metabolic process
GO:0042428 serotonin metabolic process
GO:0043025 neuronal cell body
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminalDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB04530 S,S-(2-Hydroxyethyl)ThiocysteineDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PDE1B_HUMANUBE3A_HUMANBioGRID, MINT21900206 details
PDE1B_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details