Entity Details

Primary name M3K10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02779
EntryNameM3K10_HUMAN
FullNameMitogen-activated protein kinase kinase kinase 10
TaxID9606
Evidenceevidence at protein level
Length954
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesMAP3K10

GO terms

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GOName
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004706 JUN kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007224 smoothened signaling pathway
GO:0007254 JNK cascade
GO:0007257 obsolete activation of JUN kinase activity
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043425 bHLH transcription factor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015785 Mitogen-activated protein (MAP) kinase kinase kinase 10FamilyFamily
IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR035779 MLK1-3, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
M3K10_HUMANABL2_HUMANBioGRID, IntAct20936779 details
M3K10_HUMANM3K21_HUMANBioGRID, IntAct20936779 details
M3K10_HUMANGARS_HUMANBioGRID, IntAct21988832 details
M3K10_HUMANNDF1_HUMANBioGRID12881483 details
M3K10_HUMANCDC42_HUMANBioGRID, HPRD9427749 details
M3K10_HUMANRAC1_HUMANBioGRID9427749 details
M3K10_HUMANKIF17_HUMANBioGRID9427749 details
M3K10_HUMANKIF3A_HUMANBioGRID, HPRD9427749 details
M3K10_HUMANKIFA3_HUMANBioGRID, HPRD9427749 details
M3K10_HUMAN1433E_HUMANBioGRID, HPRD9427749 details
M3K10_HUMANJIP1_HUMANBioGRID, HPRD10490659 details
M3K10_HUMANJIP2_HUMANBioGRID, HPRD10490659 details
M3K10_HUMANDYN1_HUMANBioGRID9742220 details
M3K10_HUMANHGS_HUMANBioGRID19019082 details
M3K10_HUMANCSN2_HUMANBioGRID15062575 details
M3K10_HUMANMK09_HUMANBioGRID11278395 details
M3K10_HUMANM3K10_HUMANBioGRID11278395 details
M3K10_HUMANMK01_HUMANBioGRID11278395 details
M3K10_HUMANMK14_HUMANBioGRID11278395 details
M3K10_HUMANMP2K4_HUMANBioGRID, HPRD9182538 details
M3K10_HUMANSMUF1_HUMANBioGRID20804422 details
M3K10_HUMANKIF3B_HUMANHPRD9427749 details
M3K10_HUMANHPCA_HUMANBioGRID9427749 details
M3K10_HUMANHD_HUMANBioGRID, HPRD10801775 details
M3K10_HUMANCLH1_HUMANBioGRID, HPRD12105200 details
M3K10_HUMANDLG4_HUMANBioGRID, HPRD11152698 details
M3K10_HUMANPHB_HUMANHPRD9629920 details
M3K10_HUMANTBB2A_HUMANHPRD9629920 details
M3K10_HUMANDNM1L_HUMANHPRD9742220 details
M3K10_HUMANRGAP1_HUMANHPRD9427749 details
M3K10_HUMANSH3R1_HUMANHPRD14504284 details
M3K10_HUMANCEAM1_HUMANHPRD11850617 details
M3K10_HUMANCNKR1_HUMANHPRD15753034 details