Entity Details

Primary name PTN11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06124
EntryNamePTN11_HUMAN
FullNameTyrosine-protein phosphatase non-receptor type 11
TaxID9606
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesPTPN11

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000187 obsolete activation of MAPK activity
GO:0001784 phosphotyrosine residue binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006641 triglyceride metabolic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007507 heart development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021697 cerebellar cortex formation
GO:0030159 signaling receptor complex adaptor activity
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0030971 receptor tyrosine kinase binding
GO:0031295 T cell costimulation
GO:0031748 D1 dopamine receptor binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032528 microvillus organization
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035855 megakaryocyte development
GO:0036302 atrioventricular canal development
GO:0038127 ERBB signaling pathway
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0043254 regulation of protein-containing complex assembly
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044853 plasma membrane raft
GO:0045296 cadherin binding
GO:0045778 positive regulation of ossification
GO:0045931 positive regulation of mitotic cell cycle
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0046825 regulation of protein export from nucleus
GO:0046887 positive regulation of hormone secretion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048609 multicellular organismal reproductive process
GO:0048659 smooth muscle cell proliferation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048873 homeostasis of number of cells within a tissue
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0051428 peptide hormone receptor binding
GO:0051463 negative regulation of cortisol secretion
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060020 Bergmann glial cell differentiation
GO:0060125 negative regulation of growth hormone secretion
GO:0060325 face morphogenesis
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0061582 intestinal epithelial cell migration
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0071345 cellular response to cytokine stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1904385 cellular response to angiotensin
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11FamilyFamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02779 DodecyltrimethylammoniumDrugbanksmall molecule

Interactions

208 interactions

InteractorPartnerSourcesPublicationsLink
PTN11_HUMANGRB2_HUMANBioGRID, HPRD, IntAct10080542 10212213 10747947 12531430 12577067 16371368 19380743 20473329 21706016 28514442 31585087 31980649 7523381 7534299 8041791 8647120 8702859 8959326 8995399 9254654 9361008 9362449 9632781 9660791 9824671 details
PTN11_HUMANCATA_HUMANHPRD, MINT15556604 details
PTN11_HUMANGAB1_HUMANBioGRID, HPRD, IntAct, MINT10068651 10871282 11134009 11323411 11453982 11940581 12855672 14665621 14701753 14982882 15574420 20308328 20473329 23612964 24728074 24935154 9632795 9658397 9804835 details
PTN11_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, MINT11223155 12270932 14560030 16273093 16729043 20473329 22973453 24935154 28065597 7588774 7673163 8959326 9756944 details
PTN11_HUMANERBB4_HUMANBioGRID, MINT16729043 22973453 28065597 details
PTN11_HUMANERBB2_HUMANBioGRID, HPRD, MINT16273093 16729043 22973453 28065597 8959326 9756944 details
PTN11_HUMANDDR1_HUMANHPRD, MINT16337946 22057045 details
PTN11_HUMANGAB2_HUMANBioGRID, HPRD, IntAct, MINT10068651 10391903 10871282 11287610 11334882 11782427 11812650 12135708 14982882 15170389 15356145 16253990 16371368 19172738 19909739 26839216 9660791 details
PTN11_HUMANPAXI_HUMANHPRD, IntAct, MINT10082579 10655584 14665621 23397142 24935154 8986614 details
PTN11_HUMANCAV1_HUMANBioGRID, HPRD, MINT12176037 24632723 25672415 details
PTN11_HUMANMET_HUMANBioGRID, HPRD, IntAct, MINT18579758 24728074 8662733 details
PTN11_HUMANINSR_HUMANBioGRID, HPRD, MINT7493946 8135823 8895367 9593725 details
PTN11_HUMANCD33_HUMANBioGRID, HPRD, MINT10206955 17947393 details
PTN11_HUMANSIT1_HUMANBioGRID, HPRD, MINT10209036 11433379 11491537 details
PTN11_HUMANFCG2B_HUMANBioGRID, MINT10382761 11453982 9232445 details
PTN11_HUMANPECA1_HUMANBioGRID, HPRD, MINT10350061 10704309 10801826 20723025 9054388 9312087 9774457 details
PTN11_HUMANSLAF1_HUMANBioGRID, HPRD, MINT11313386 11689425 11806999 details
PTN11_HUMANFRS3_HUMANHPRD, MINT11432792 details
PTN11_HUMANFLT3_HUMANBioGRID, MINT16684964 details
PTN11_HUMANIRS1_HUMANBioGRID, HPRD, MINT11781100 22974441 7513703 7935386 8505282 9535915 9756938 details
PTN11_HUMANPGFRB_HUMANBioGRID, HPRD, IntAct, MINT11266449 12614164 12681492 23397142 23922991 7530043 7688466 7691811 8041791 8119896 8183548 8538796 details
PTN11_HUMANIGF1R_HUMANBioGRID, HPRD, MINT10082579 28065597 7642582 8895367 details
PTN11_HUMANIL3RB_HUMANBioGRID, HPRD, MINT15194700 9162089 9254654 9973406 details
PTN11_HUMANKI2L1_HUMANMINT9751747 details
PTN11_HUMANFRS2_HUMANBioGRID, HPRD, IntAct, MINT10650943 11360177 11447289 12974390 16573649 22974441 25159185 29997244 9632781 details
PTN11_HUMANLEPR_HUMANBioGRID, HPRD, MINT11018044 11342028 9600917 details
PTN11_HUMANEPHA2_HUMANBioGRID, HPRD, MINT, UniProt10655584 28065597 details
PTN11_HUMANRPIA_HUMANBioGRID, IntAct, MINT21516116 25416956 details
PTN11_HUMANSRC_HUMANBioGRID, HPRD, MINT14687660 20308328 8959326 details
PTN11_HUMANNEBU_HUMANBioGRID, IntAct23414517 details
PTN11_HUMANVGFR1_HUMANBioGRID, HPRD, IntAct23397142 25241761 9600074 details
PTN11_HUMANCRKL_HUMANBioGRID, HPRD, IntAct23397142 9344843 9660791 details
PTN11_HUMANANDR_HUMANBioGRID, IntAct24728074 details
PTN11_HUMANKIT_HUMANBioGRID, HPRD, IntAct12444928 24728074 7523381 9528781 details
PTN11_HUMANLNX1_HUMANBioGRID, IntAct25814554 details
PTN11_HUMANTRI32_HUMANBioGRID, IntAct25416956 27229929 31515488 details
PTN11_HUMANCD244_HUMANBioGRID, UniProt10358138 24642916 details
PTN11_HUMANGEMI_HUMANBioGRID, IntAct32296183 details
PTN11_HUMANTLK1_HUMANBioGRID, IntAct27229929 32296183 details
PTN11_HUMANLMTK1_HUMANBioGRID, MINT28065597 details
PTN11_HUMANERBB3_HUMANBioGRID, MINT22973453 28065597 9756944 details
PTN11_HUMANROR2_HUMANBioGRID, MINT28065597 details
PTN11_HUMANPTK7_HUMANBioGRID, MINT28065597 details
PTN11_HUMANEPHA1_HUMANBioGRID, MINT28065597 details
PTN11_HUMANTIE2_HUMANBioGRID, HPRD, MINT10521483 28065597 details
PTN11_HUMANFGFR2_HUMANBioGRID, MINT28065597 details
PTN11_HUMANFGFR4_HUMANBioGRID, MINT28065597 details
PTN11_HUMANVGFR2_HUMANBioGRID, HPRD, MINT16339483 28065597 9405464 details
PTN11_HUMANDDI1_HUMANIntAct31515488 details
PTN11_HUMANSPY1_HUMANIntAct24935154 details
PTN11_HUMANCDC73_HUMANBioGRID, IntAct21726809 26742426 details
PTN11_HUMANSHPS1_HUMANBioGRID, HPRD, IntAct10962556 15888547 19299420 20473329 8943344 details
PTN11_HUMANHNRPQ_HUMANBioGRID9847309 details
PTN11_HUMANROS1_HUMANBioGRID11266449 details
PTN11_HUMANSTA5A_HUMANBioGRID, HPRD10617656 12060651 12237455 details
PTN11_HUMANSTA5B_HUMANBioGRID, HPRD10617656 details
PTN11_HUMANCSF3R_HUMANBioGRID, HPRD9824671 details
PTN11_HUMANJAK1_HUMANBioGRID, HPRD11036942 12270932 12403768 8995399 9794795 details
PTN11_HUMANJAK2_HUMANBioGRID, HPRD7559603 8639815 8912646 8995399 9442080 details
PTN11_HUMANIL4RA_HUMANBioGRID, HPRD11714803 details
PTN11_HUMANIL6RB_HUMANBioGRID, HPRD10777583 10946280 12403768 9195977 9388212 9794795 details
PTN11_HUMANSOCS3_HUMANBioGRID, HPRD10777583 12403768 17138568 details
PTN11_HUMANSHIP1_HUMANBioGRID, HPRD11157475 11453982 9110989 details
PTN11_HUMANEPOR_HUMANBioGRID, HPRD7534299 8639815 details
PTN11_HUMANP85A_HUMANBioGRID, HPRD10962556 11593409 16371368 26839216 8647120 9361008 9565634 9632795 9660791 9886492 9918857 details
PTN11_HUMANFAK2_HUMANBioGRID, HPRD10880513 details
PTN11_HUMANGHR_HUMANBioGRID, HPRD10976913 9442080 9632636 details
PTN11_HUMANFCRL3_HUMANBioGRID12051764 details
PTN11_HUMANCEAM1_HUMANBioGRID, HPRD12108545 9867848 details
PTN11_HUMANPTN11_HUMANBioGRID27432908 9632795 9847309 details
PTN11_HUMANM3K5_HUMANBioGRID19287004 details
PTN11_HUMANTXNIP_HUMANBioGRID26527736 26919541 details
PTN11_HUMANPGFRA_HUMANBioGRID, HPRD21996738 8943348 8959326 details
PTN11_HUMANBEX1_HUMANBioGRID27229929 details
PTN11_HUMANBEX2_HUMANBioGRID27229929 details
PTN11_HUMANGO45_HUMANBioGRID27229929 details
PTN11_HUMANCTDS1_HUMANBioGRID27229929 details
PTN11_HUMANDMRTC_HUMANBioGRID27229929 details
PTN11_HUMANF71E1_HUMANBioGRID27229929 details
PTN11_HUMANGOGA2_HUMANBioGRID27229929 details
PTN11_HUMANT2AG_HUMANBioGRID27229929 details
PTN11_HUMANNSUN5_HUMANBioGRID27229929 details
PTN11_HUMANORML3_HUMANBioGRID27229929 details
PTN11_HUMANPKHA4_HUMANBioGRID27229929 31091453 details
PTN11_HUMANKCC1B_HUMANBioGRID27229929 details
PTN11_HUMANOBF1_HUMANBioGRID27229929 details
PTN11_HUMANMOG1_HUMANBioGRID27229929 details
PTN11_HUMANSERF2_HUMANBioGRID27229929 details
PTN11_HUMANPEDF_HUMANBioGRID27229929 details
PTN11_HUMANSRS10_HUMANBioGRID27229929 details
PTN11_HUMANS38A1_HUMANBioGRID27229929 details
PTN11_HUMANSARCO_HUMANBioGRID27229929 details
PTN11_HUMANSTAT1_HUMANBioGRID, HPRD12270932 27229929 details
PTN11_HUMANTRM2_HUMANBioGRID27229929 details
PTN11_HUMANFBXW7_HUMANBioGRID28287082 details
PTN11_HUMANCASL_HUMANBioGRID, HPRD19275884 8879209 details
PTN11_HUMANPK3CA_HUMANBioGRID26839216 9565634 9660791 details
PTN11_HUMANSHC1_HUMANBioGRID, HPRD10650943 11453982 details
PTN11_HUMANPK3CG_HUMANBioGRID, HPRD10386953 20723025 details
PTN11_HUMANLRP1_HUMANBioGRID23922991 details
PTN11_HUMANILK_HUMANBioGRID19299420 details
PTN11_HUMANTSC2_HUMANBioGRID19299420 details
PTN11_HUMANGRP75_HUMANBioGRID19299420 details
PTN11_HUMANBIP_HUMANBioGRID19299420 details
PTN11_HUMANENPL_HUMANBioGRID19299420 details
PTN11_HUMANAKT1_HUMANBioGRID19299420 details
PTN11_HUMANCH60_HUMANBioGRID19299420 details
PTN11_HUMANNOX4_HUMANBioGRID19299420 details
PTN11_HUMANCALR_HUMANBioGRID19299420 details
PTN11_HUMANCOASY_HUMANBioGRID19763791 details
PTN11_HUMANTAU_HUMANBioGRID31201283 details
PTN11_HUMANSIG12_HUMANHPRD11328818 details
PTN11_HUMANMPZL1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10681522 11751924 28514442 9792637 details
PTN11_HUMANGASR_HUMANHPRD, MINT16963136 details
PTN11_HUMANPLCG1_HUMANHPRD, MINT15563458 9020117 details
PTN11_HUMANBTLA_HUMANBioGRID, HPRD, MINT12796776 14652006 details
PTN11_HUMANPDCD1_HUMANBioGRID, IntAct, MINT15240681 28046066 28514442 details
PTN11_HUMANG6B_HUMANBioGRID, HPRD, MINT11544253 details
PTN11_HUMANLYAM2_HUMANBioGRID, HPRD, MINT11602579 details
PTN11_HUMANTNR1A_HUMANHPRD, MINT11786908 details
PTN11_HUMANB3AT_HUMANMINT12070037 details
PTN11_HUMANKI2L3_HUMANMINT8648092 details
PTN11_HUMANITB3_HUMANMINT12791772 details
PTN11_HUMANDOK1_HUMANMINT15546884 details
PTN11_HUMANSGCG_HUMANIntAct23414517 details
PTN11_HUMANMK03_HUMANHPRD, IntAct23397142 8197172 details
PTN11_HUMANTNIK_HUMANIntAct31413325 details
PTN11_HUMANSOS1_HUMANBioGRID, HPRD, IntAct16371368 20473329 9344843 9632781 details
PTN11_HUMANFAK1_HUMANBioGRID, IntAct10082579 20473329 21726809 details
PTN11_HUMANTRML1_HUMANBioGRID, HPRD15128762 details
PTN11_HUMANSTAT3_HUMANBioGRID, HPRD11594781 26775640 details
PTN11_HUMANIRS2_HUMANBioGRID, HPRD8910607 details
PTN11_HUMANPLCG2_HUMANBioGRID12135708 details
PTN11_HUMANGAB3_HUMANBioGRID, HPRD11739737 details
PTN11_HUMANBCAR1_HUMANBioGRID9188452 details
PTN11_HUMANCADH5_HUMANBioGRID, HPRD10681592 details
PTN11_HUMANCTNB1_HUMANBioGRID10681592 details
PTN11_HUMANLAIR1_HUMANBioGRID, HPRD10903717 9285412 details
PTN11_HUMANPILRA_HUMANBioGRID, HPRD10660620 10903717 details
PTN11_HUMANFYN_HUMANBioGRID, HPRD10212213 11157475 details
PTN11_HUMANSLAF5_HUMANBioGRID11689425 details
PTN11_HUMANLY9_HUMANBioGRID11689425 details
PTN11_HUMANPRLR_HUMANBioGRID, HPRD10991949 14522994 details
PTN11_HUMANSIG11_HUMANBioGRID, HPRD11986327 details
PTN11_HUMANCBL_HUMANBioGRID, HPRD11157475 17330819 18519587 details
PTN11_HUMANSOCS1_HUMANBioGRID14522994 29991678 details
PTN11_HUMANPAF1_HUMANBioGRID21726809 27880917 details
PTN11_HUMANLEO1_HUMANBioGRID21726809 details
PTN11_HUMANCTR9_HUMANBioGRID21726809 27880917 details
PTN11_HUMANRTF1_HUMANBioGRID21726809 details
PTN11_HUMANWDR61_HUMANBioGRID21726809 details
PTN11_HUMANCBLB_HUMANBioGRID17330819 details
PTN11_HUMANCXCR4_HUMANBioGRID, HPRD11157475 details
PTN11_HUMANLRRK1_HUMANBioGRID20697350 details
PTN11_HUMANCRK_HUMANBioGRID10464310 19380743 details
PTN11_HUMANFAS_HUMANBioGRID23269672 details
PTN11_HUMANCOP1_HUMANBioGRID23269672 details
PTN11_HUMANPD1L1_HUMANBioGRID11224527 details
PTN11_HUMANNTRK1_HUMANBioGRID, HPRD25921289 9282923 details
PTN11_HUMANDYN2_HUMANBioGRID21996738 details
PTN11_HUMANGARE2_HUMANBioGRID24003223 details
PTN11_HUMANPRP19_HUMANBioGRID27213290 details
PTN11_HUMANPTN6_HUMANBioGRID, HPRD27432908 8541543 details
PTN11_HUMANGRASP_HUMANBioGRID15173175 details
PTN11_HUMANSIGL7_HUMANBioGRID, HPRD10499918 15703304 details
PTN11_HUMANSIGL9_HUMANBioGRID15703304 details
PTN11_HUMANHDAC6_HUMANBioGRID26775640 details
PTN11_HUMANDDX58_HUMANBioGRID28287082 details
PTN11_HUMANFGFR1_HUMANBioGRID18022941 details
PTN11_HUMANE2F1_HUMANBioGRID27720894 details
PTN11_HUMANPVR_HUMANBioGRID17717529 details
PTN11_HUMANRACK1_HUMANBioGRID11964397 details
PTN11_HUMANANXA2_HUMANBioGRID9565634 details
PTN11_HUMANSHC4_HUMANBioGRID28213521 details
PTN11_HUMANTYK2_HUMANBioGRID9794795 details
PTN11_HUMANCL12A_HUMANBioGRID15238421 details
PTN11_HUMANTRAF6_HUMANBioGRID31942069 details
PTN11_HUMANINAR1_HUMANHPRD9029147 details
PTN11_HUMANKPCA_HUMANHPRD11781100 details
PTN11_HUMANKPCB_HUMANHPRD11781100 details
PTN11_HUMANTIE1_HUMANHPRD10949653 details
PTN11_HUMANSPY2_HUMANHPRD15031289 details
PTN11_HUMANHNRPU_HUMANHPRD8943344 details
PTN11_HUMANDAB1_HUMANHPRD15062102 details
PTN11_HUMANIRS4_HUMANHPRD12774026 details
PTN11_HUMANACTN4_HUMANHPRD11382784 details
PTN11_HUMANMVP_HUMANHPRD15133037 15588985 details
PTN11_HUMANKPCL_HUMANHPRD11781100 details
PTN11_HUMANPHAG1_HUMANHPRD10790433 details
PTN11_HUMANBKRB2_HUMANHPRD12177051 details
PTN11_HUMANRHG01_HUMANHPRD15169898 15588985 details
PTN11_HUMANFCERB_HUMANHPRD9379041 details
PTN11_HUMANKI2LA_HUMANHPRD15187115 details
PTN11_HUMANRET_HUMANHPRD12959980 details
PTN11_HUMANINGR1_HUMANHPRD10022928 details
PTN11_HUMANVGFR3_HUMANHPRD15102829 details
PTN11_HUMANUFO_HUMANHPRD15507525 details
PTN11_HUMANNMDE2_HUMANHPRD10381539 details
PTN11_HUMANTPOR_HUMANHPRD8541543 details
PTN11_HUMANNTRK2_HUMANHPRD10386953 details
PTN11_HUMANIKKA_HUMANHPRD11136824 details
PTN11_HUMANPILRB_HUMANHPRD10327049 11812650 details
PTN11_HUMANM3K4_HUMANHPRD15601262 details
PTN11_HUMANCTLA4_HUMANHPRD8638161 details
PTN11_HUMANBCR_HUMANHPRD12115002 details
PTN11_HUMANLIFR_HUMANHPRD10800945 details
PTN11_HUMANLCK_HUMANHPRD10617656 details
PTN11_HUMANNKG2A_HUMANHPRD9485206 details