Entity Details

Primary name PSME1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06323
EntryNamePSME1_HUMAN
FullNameProteasome activator complex subunit 1
TaxID9606
Evidenceevidence at protein level
Length249
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPSME1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008537 proteasome activator complex
GO:0010950 positive regulation of endopeptidase activity
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016579 protein deubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061133 endopeptidase activator activity
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Domains

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DomainNameCategoryType
IPR003185 Proteasome activator PA28, N-terminal domainDomainDomain
IPR003186 Proteasome activator PA28, C-terminal domainDomainDomain
IPR009077 Proteasome activator PA28FamilyFamily
IPR036252 Proteasome activator superfamilyFamilyHomologous superfamily
IPR036996 Proteasome activator PA28, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036997 Proteasome activator PA28, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
PSME1_HUMANCHD3_HUMANBioGRID, IntAct16169070 details
PSME1_HUMANPFD1_HUMANBioGRID, IntAct16169070 details
PSME1_HUMANPSME1_HUMANBioGRID, IntAct16169070 25416956 9325261 9346951 9385652 9403698 details
PSME1_HUMANVINC_HUMANBioGRID, IntAct16169070 details
PSME1_HUMANVIME_HUMANBioGRID, IntAct16169070 details
PSME1_HUMANUBP22_HUMANBioGRID, IntAct16169070 details
PSME1_HUMANPSME2_HUMANBioGRID, IntAct16189514 19017543 22863883 22939629 32296183 8663520 9325261 9346951 details
PSME1_HUMANAT1B1_HUMANBioGRID, MINT21900206 details
PSME1_HUMANCDC37_HUMANBioGRID, MINT21900206 details
PSME1_HUMANAIMP2_HUMANBioGRID, MINT21900206 details
PSME1_HUMANP55G_HUMANBioGRID, MINT21900206 details
PSME1_HUMANRPP14_HUMANBioGRID, MINT21900206 details
PSME1_HUMANSETB1_HUMANBioGRID, MINT21900206 details
PSME1_HUMANSMN_HUMANBioGRID, MINT21900206 details
PSME1_HUMANKITH_HUMANBioGRID, MINT21900206 details
PSME1_HUMANFGFR3_HUMANIntAct32814053 details
PSME1_HUMANNMDE3_HUMANIntAct32814053 details
PSME1_HUMANGELS_HUMANIntAct32814053 details
PSME1_HUMANTOIP1_HUMANIntAct32814053 details
PSME1_HUMANUBQL1_HUMANIntAct32814053 details
PSME1_HUMANJPH3_HUMANIntAct32814053 details
PSME1_HUMANEMD_HUMANBioGRID12755701 details
PSME1_HUMANIF6_HUMANBioGRID16169070 details
PSME1_HUMANTBB4B_HUMANBioGRID16169070 details
PSME1_HUMANA4_HUMANBioGRID21832049 details
PSME1_HUMANCENPR_HUMANIntAct16169070 details
PSME1_HUMANTBB2A_HUMANIntAct16169070 details
PSME1_HUMANNEP1_HUMANIntAct16169070 details
PSME1_HUMANPSB9_HUMANBioGRID, IntAct11745344 26186194 28514442 30833792 details
PSME1_HUMANPSB7_HUMANBioGRID, IntAct11745344 26186194 28514442 details
PSME1_HUMANPSA1_HUMANBioGRID, IntAct10799514 22939629 24429290 26186194 28514442 29568061 details
PSME1_HUMANFBX7_HUMANBioGRID, IntAct27497298 28514442 details
PSME1_HUMANDISC1_HUMANIntAct31413325 details
PSME1_HUMANFXR1_HUMANMINT21653829 details
PSME1_HUMANFXR2_HUMANMINT21653829 details
PSME1_HUMANPRS8_HUMANBioGRID10799514 9620878 details
PSME1_HUMANPSA6_HUMANBioGRID12419264 22939629 details
PSME1_HUMANPRS4_HUMANBioGRID12419264 details
PSME1_HUMANPSA2_HUMANBioGRID19193609 31114588 details
PSME1_HUMANTBG1_HUMANBioGRID10225950 details
PSME1_HUMANPSB6_HUMANBioGRID11745344 details
PSME1_HUMANPSA4_HUMANBioGRID11745344 details
PSME1_HUMANPSMD6_HUMANBioGRID11745344 details
PSME1_HUMANPSB8_HUMANBioGRID11745344 details
PSME1_HUMANPSB10_HUMANBioGRID11745344 details
PSME1_HUMANPSA3_HUMANBioGRID22939629 30009671 details
PSME1_HUMANPSDE_HUMANBioGRID17323924 24429290 28821611 details
PSME1_HUMANADRM1_HUMANBioGRID24429290 details
PSME1_HUMANU2AF2_HUMANBioGRID26641092 details