Entity Details

Primary name SPRY1
Entity type gene
Source Source Link

Details

PrimaryID10252
RefseqGene
SymbolSPRY1
Namesprouty RTK signaling antagonist 1
Chromosome4
Location4q28.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-07
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSPY1_HUMAN

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001759 organ induction
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008285 negative regulation of cell population proliferation
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048513 animal organ development
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060449 bud elongation involved in lung branching
GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902747 negative regulation of lens fiber cell differentiation

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
SPRY1ATXN7BioGRID, IntAct21078624 details
SPRY1CACNA1ABioGRID, IntAct21078624 details
SPRY1HRGBioGRID, IntAct21988832 details
SPRY1KPNA2BioGRID, IntAct21988832 details
SPRY1STAT3BioGRID, IntAct21988832 details
SPRY1YY1BioGRID, IntAct21988832 details
SPRY1GEMIN4BioGRID, HPRD, IntAct12869526 21988832 32296183 details
SPRY1SOCS4BioGRID, IntAct21988832 details
SPRY1MEOX2BioGRID, IntAct25416956 31515488 32296183 details
SPRY1SPRY2BioGRID, IntAct15004239 25416956 details
SPRY1HOXA1BioGRID, IntAct21516116 25416956 32296183 details
SPRY1KRTAP10-7BioGRID, IntAct25416956 32296183 details
SPRY1KRTAP10-8BioGRID, IntAct25416956 32296183 details
SPRY1KRTAP10-9BioGRID, IntAct25416956 32296183 details
SPRY1KRTAP10-11BioGRID, IntAct25416956 32296183 details
SPRY1NOTCH2NLABioGRID, IntAct25416956 31515488 32296183 details
SPRY1MDFIBioGRID, IntAct25416956 32296183 details
SPRY1KRTAP4-2BioGRID, IntAct25416956 details
SPRY1OTX1BioGRID, IntAct25416956 31515488 details
SPRY1CREB5BioGRID, IntAct25416956 32296183 details
SPRY1LCE1BBioGRID, IntAct25416956 details
SPRY1LCE2DBioGRID, IntAct25416956 31515488 32296183 details
SPRY1HEXIM2BioGRID, IntAct25416956 details
SPRY1R3HDM2BioGRID, IntAct25416956 details
SPRY1KRTAP12-2BioGRID, IntAct32296183 details
SPRY1ADAMTSL4BioGRID, IntAct32296183 details
SPRY1HSF2BPBioGRID, IntAct32296183 details
SPRY1LCE2CBioGRID, IntAct32296183 details
SPRY1LCE1DBioGRID, IntAct32296183 details
SPRY1RELBioGRID, IntAct32296183 details
SPRY1KRTAP12-3BioGRID, IntAct32296183 details
SPRY1CYSRT1BioGRID, IntAct32296183 details
SPRY1LCE4ABioGRID, IntAct32296183 details
SPRY1UBASH3ABioGRID, IntAct32296183 details
SPRY1KRTAP4-12BioGRID, IntAct32296183 details
SPRY1PRKAB2BioGRID, IntAct32296183 details
SPRY1KRTAP9-2BioGRID, IntAct32296183 details
SPRY1KRTAP3-2BioGRID, IntAct32296183 details
SPRY1ADAM12BioGRID, IntAct32296183 details
SPRY1POLR1CBioGRID, IntAct32296183 details
SPRY1LCE2ABioGRID, IntAct32296183 details
SPRY1FARS2BioGRID, IntAct32296183 details
SPRY1CDR2LBioGRID, IntAct32296183 details
SPRY1FBLN1BioGRID, IntAct32296183 details
SPRY1PRKAA2BioGRID, IntAct32296183 details
SPRY1LCE5ABioGRID, IntAct32296183 details
SPRY1CHRDBioGRID, IntAct32296183 details
SPRY1LCE3ABioGRID, IntAct32296183 details
SPRY1MB21D2BioGRID, IntAct32296183 details
SPRY1KRTAP5-9BioGRID, IntAct32296183 details
SPRY1KRT31BioGRID, IntAct32296183 details
SPRY1KRTAP1-1BioGRID, IntAct32296183 details
SPRY1ZNF837BioGRID, IntAct32296183 details
SPRY1KRTAP11-1BioGRID, IntAct32296183 details
SPRY1LCE1ABioGRID, IntAct32296183 details
SPRY1PCSK5BioGRID, IntAct32296183 details
SPRY1GNEBioGRID, IntAct32296183 details
SPRY1VWC2BioGRID, IntAct32296183 details
SPRY1LCE3CBioGRID, IntAct32296183 details
SPRY1CCDC57BioGRID, IntAct32296183 details
SPRY1NTMBioGRID, IntAct32296183 details
SPRY1LCE1FBioGRID, IntAct32296183 details
SPRY1ZNF23BioGRID, IntAct32296183 details
SPRY1ZNF417BioGRID, IntAct32296183 details
SPRY1ZNF441BioGRID, IntAct32296183 details
SPRY1FHL5BioGRID, IntAct32296183 details
SPRY1GUCD1BioGRID, IntAct32296183 details
SPRY1SMCPBioGRID, IntAct32296183 details
SPRY1KPRPBioGRID, IntAct32296183 details
SPRY1KRTAP9-3BioGRID, IntAct32296183 details
SPRY1ZNF330BioGRID, IntAct32296183 details
SPRY1TFAP2DBioGRID, IntAct32296183 details
SPRY1LCE3DBioGRID, IntAct32296183 details
SPRY1TGM7BioGRID, IntAct32296183 details
SPRY1LCE1CBioGRID, IntAct32296183 details
SPRY1INCA1BioGRID, IntAct32296183 details
SPRY1KRTAP10-1BioGRID, IntAct25416956 31515488 32296183 details
SPRY1PTPN11IntAct24935154 details
SPRY1KRTAP10-3BioGRID25416956 details
SPRY1ANKRD11BioGRID32296183 details
SPRY1KRTAP1-3BioGRID32296183 details
SPRY1GRB2BioGRID, HPRD, MINT12402043 16893902 details
SPRY1CBLBioGRID, MINT15004239 16893902 19915061 details
SPRY1FXR1MINT21653829 details
SPRY1FXR2MINT21653829 details
SPRY1TESK1BioGRID17974561 details
SPRY1NEDD4BioGRID19864419 details
SPRY1SH3KBP1BioGRID15962011 details
SPRY1PLCG1BioGRID19915061 details
SPRY1MAP4K1BioGRID19915061 details
SPRY1CBLBBioGRID19915061 details
SPRY1LATBioGRID19915061 details
SPRY1TGOLN2BioGRID, IntAct29568061 details
SPRY1BAG3BioGRID23824909 details
SPRY1LAMP2BioGRID34079125 details
SPRY1LAMTOR1BioGRID34079125 details
SPRY1RAB5CBioGRID34079125 details
SPRY1ELAVL1BioGRID19322201 details
SPRY1VIRMABioGRID29507755 details