Entity Details

Primary name GRIK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13002
EntryNameGRIK2_HUMAN
FullNameGlutamate receptor ionotropic, kainate 2
TaxID9606
Evidenceevidence at protein level
Length908
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesGRIK2

GO terms

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GOName
GO:0001662 behavioral fear response
GO:0005234 extracellularly glutamate-gated ion channel activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0007215 glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008066 glutamate receptor activity
GO:0014069 postsynaptic density
GO:0015276 ligand-gated ion channel activity
GO:0015277 kainate selective glutamate receptor activity
GO:0019228 neuronal action potential
GO:0030165 PDZ domain binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0032839 dendrite cytoplasm
GO:0032983 kainate selective glutamate receptor complex
GO:0035249 synaptic transmission, glutamatergic
GO:0038023 signaling receptor activity
GO:0042734 presynaptic membrane
GO:0042802 identical protein binding
GO:0043113 receptor clustering
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045211 postsynaptic membrane
GO:0046328 regulation of JNK cascade
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0050804 modulation of chemical synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0051402 neuron apoptotic process
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060080 inhibitory postsynaptic potential
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098978 glutamatergic synapse
GO:0099507 ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
GO:0120169 detection of cold stimulus involved in thermoception
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR001320 Ionotropic glutamate receptorDomainDomain
IPR001508 Ionotropic glutamate receptor, metazoaFamilyFamily
IPR001828 Receptor, ligand binding regionDomainDomain
IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomainDomain
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00237 ButabarbitalDrugbanksmall molecule
DB00241 ButalbitalDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00306 TalbutalDrugbanksmall molecule
DB00312 PentobarbitalDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00463 MetharbitalDrugbanksmall molecule
DB00599 ThiopentalDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00849 MethylphenobarbitalDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01351 AmobarbitalDrugbanksmall molecule
DB01352 AprobarbitalDrugbanksmall molecule
DB01353 ButobarbitalDrugbanksmall molecule
DB01354 HeptabarbitalDrugbanksmall molecule
DB01355 HexobarbitalDrugbanksmall molecule
DB01483 BarbitalDrugbanksmall molecule
DB01496 Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedioneDrugbanksmall molecule
DB02852 Domoic AcidDrugbanksmall molecule
DB02999 Quisqualic acidDrugbanksmall molecule
DB03425 2s,4r-4-MethylglutamateDrugbanksmall molecule