Entity Details

Primary name PAK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13153
EntryNamePAK1_HUMAN
FullNameSerine/threonine-protein kinase PAK 1
TaxID9606
Evidenceevidence at protein level
Length545
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPAK1

GO terms

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GOName
GO:0001726 ruffle
GO:0006974 cellular response to DNA damage stimulus
GO:0008284 positive regulation of cell population proliferation
GO:0030425 dendrite
GO:0090314 positive regulation of protein targeting to membrane
GO:0004672 protein kinase activity
GO:0005911 cell-cell junction
GO:0006915 apoptotic process
GO:0016310 phosphorylation
GO:0031116 positive regulation of microtubule polymerization
GO:0042060 wound healing
GO:0046777 protein autophosphorylation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0048013 ephrin receptor signaling pathway
GO:0005524 ATP binding
GO:0030424 axon
GO:0032869 cellular response to insulin stimulus
GO:0050852 T cell receptor signaling pathway
GO:0005737 cytoplasm
GO:0001934 positive regulation of protein phosphorylation
GO:0016477 cell migration
GO:0090063 positive regulation of microtubule nucleation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0048812 neuron projection morphogenesis
GO:0005886 plasma membrane
GO:0006887 exocytosis
GO:0030018 Z disc
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0031295 T cell costimulation
GO:0004674 protein serine/threonine kinase activity
GO:0005518 collagen binding
GO:0005654 nucleoplasm
GO:0032147 activation of protein kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0014704 intercalated disc
GO:0032587 ruffle membrane
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0060244 negative regulation of cell proliferation involved in contact inhibition
GO:0005694 chromosome
GO:0031532 actin cytoskeleton reorganization
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0030027 lamellipodium
GO:0032991 protein-containing complex
GO:0045773 positive regulation of axon extension
GO:0051496 positive regulation of stress fiber assembly
GO:0001666 response to hypoxia
GO:0005884 actin filament
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0106310 protein serine kinase activity
GO:0042802 identical protein binding
GO:0043015 gamma-tubulin binding
GO:0106311 protein threonine kinase activity
GO:0010763 positive regulation of fibroblast migration
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0048754 branching morphogenesis of an epithelial tube
GO:0006338 chromatin remodeling
GO:0019901 protein kinase binding
GO:0030010 establishment of cell polarity
GO:0005829 cytosol
GO:0021549 cerebellum development
GO:0030335 positive regulation of cell migration
GO:0031965 nuclear membrane

Subcellular Location

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Subcellular Location
Cell projection
Nucleus
Cytoplasm
Chromosome
Cell membrane
Cell junction

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033923 p21 activated kinase binding domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

140 interactions

InteractorPartnerSourcesPublicationsLink
PAK1_HUMANCDC42_HUMANBioGRID, DIP, HPRD, IntAct, mbinfo, MINT10360579 10684602 10802735 11157984 12606577 12650940 12879077 15548653 16678097 18057010 18426980 19596003 20936779 21029865 21048135 21167153 23175184 23455922 24276241 25150978 31478661 7744004 8107774 9535855 9705280 unassigned1271 details
PAK1_HUMANCD11B_HUMANHPRD, IntAct, MINT12624090 16413544 details
PAK1_HUMANRAC1_HUMANBioGRID, DIP, HPIDb, HPRD, InnateDB, IntAct, MINT, UniProt10706722 10802735 11030651 11130076 11134022 11950930 12650940 12879077 15075243 15143066 15212766 15548653 15673687 15688026 16002993 16492808 16551621 16678097 17245428 17389360 18426980 19270716 19277120 19327867 19596003 19693014 19732720 19961560 20810653 20936779 21029865 21167153 21454543 21474670 22117219 22581261 24056087 24172987 24625804 24792722 25150978 25468898 25819133 25843002 26175416 29615491 7744004 8107774 9535855 details
PAK1_HUMANRHOU_HUMANBioGRID, HPRD, IntAct, mbinfo, MINT14521508 15350535 15556869 18086875 26598620 details
PAK1_HUMANARHG7_HUMANBioGRID, HPRD, IntAct, MINT10330411 11157752 16101281 16407834 16492808 16628223 20936779 23455922 26264872 28514442 29997244 31980649 32203420 32814053 details
PAK1_HUMANRAF1_HUMANBioGRID, HPRD, MINT10205168 11733498 12551923 17097642 9234708 9823899 details
PAK1_HUMANCRPAK_HUMANHPRD, IntAct16278681 details
PAK1_HUMANSRC8_HUMANMINT18344974 details
PAK1_HUMANDYR1B_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANHS90A_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANZN823_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANPAK1_HUMANBioGRID, DIP, HPRD, IntAct10805734 10975528 11278486 11382770 11804587 16204230 16278681 17389360 18586681 20936779 22153498 31980649 9032240 details
PAK1_HUMANMYNN_HUMANBioGRID, IntAct20936779 details
PAK1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct15324660 20936779 details
PAK1_HUMAN1433Z_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANZ3H7A_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANZBT18_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANZN418_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANCPLN1_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANZNF83_HUMANBioGRID, IntAct20936779 details
PAK1_HUMANDYL1_HUMANBioGRID, DIP, HPRD, IntAct15193260 17389360 21988832 32814053 details
PAK1_HUMANDYL2_HUMANBioGRID, IntAct21988832 details
PAK1_HUMANARHG6_HUMANBioGRID, HPRD, IntAct, MINT15688026 21900206 23455922 28514442 31980649 32203420 9659915 details
PAK1_HUMANTGM2_HUMANBioGRID, MINT21900206 details
PAK1_HUMANNCK2_HUMANBioGRID, HPRD, IntAct10026169 11557983 23455922 25416956 26186194 28514442 30886144 31515488 31980649 32296183 details
PAK1_HUMANLIMK1_HUMANBioGRID, HPRD, mbinfo10559936 10652353 11340065 details
PAK1_HUMANRHOJ_HUMANBioGRID, HPRD, IntAct, mbinfo10967094 14521508 28514442 32814053 details
PAK1_HUMANAKT1_HUMANBioGRID, HPRD, IntAct12138087 14749719 23397142 24886428 details
PAK1_HUMANEGFR_HUMANBioGRID, HPRD, IntAct12522133 24658140 25402006 31980649 details
PAK1_HUMANPCBP1_HUMANDIP17389360 details
PAK1_HUMANROAA_HUMANDIP17389360 details
PAK1_HUMANRL27A_HUMANDIP17389360 details
PAK1_HUMANEIF3E_HUMANDIP17389360 details
PAK1_HUMANPGM1_HUMANDIP17389360 details
PAK1_HUMANRL7A_HUMANDIP17389360 details
PAK1_HUMANSRSF2_HUMANDIP17389360 details
PAK1_HUMANTBCB_HUMANDIP17389360 details
PAK1_HUMANSRSF5_HUMANDIP17389360 details
PAK1_HUMANFLNA_HUMANDIP, HPRD12198493 17389360 details
PAK1_HUMANRIT1_HUMANIntAct29734338 details
PAK1_HUMANTSACC_HUMANIntAct32814053 details
PAK1_HUMANRFFL_HUMANIntAct32814053 details
PAK1_HUMANZHX1R_HUMANIntAct32814053 details
PAK1_HUMANSPSB1_HUMANIntAct32814053 details
PAK1_HUMANSEM4G_HUMANIntAct32814053 details
PAK1_HUMANTEX12_HUMANIntAct32814053 details
PAK1_HUMANZN444_HUMANIntAct32814053 details
PAK1_HUMANTTC12_HUMANIntAct32814053 details
PAK1_HUMANCK054_HUMANIntAct32814053 details
PAK1_HUMANKLH20_HUMANIntAct32814053 details
PAK1_HUMANPNKD_HUMANIntAct32814053 details
PAK1_HUMANHNRPQ_HUMANIntAct32814053 details
PAK1_HUMANNOD1_HUMANIntAct32814053 details
PAK1_HUMANTI17B_HUMANIntAct32814053 details
PAK1_HUMANSTX11_HUMANIntAct32814053 details
PAK1_HUMANTELT_HUMANIntAct32814053 details
PAK1_HUMANMK11_HUMANIntAct32814053 details
PAK1_HUMANOTX2_HUMANIntAct32814053 details
PAK1_HUMANLASP1_HUMANIntAct32814053 details
PAK1_HUMANGRB10_HUMANIntAct32814053 details
PAK1_HUMANADDA_HUMANIntAct32814053 details
PAK1_HUMANPPAL_HUMANIntAct32814053 details
PAK1_HUMANFAP20_HUMANIntAct32814053 details
PAK1_HUMANTCP1L_HUMANIntAct32814053 details
PAK1_HUMANARHG2_HUMANBioGRID, HPRD14970201 details
PAK1_HUMANARC1B_HUMANBioGRID, HPRD14749719 details
PAK1_HUMANCD11A_HUMANBioGRID12624090 details
PAK1_HUMANABI3_HUMANBioGRID, HPRD11956071 details
PAK1_HUMANPLCG1_HUMANBioGRID, HPRD12085993 details
PAK1_HUMANPK1IP_HUMANBioGRID, HPRD11371639 details
PAK1_HUMANCDK5_HUMANBioGRID, HPRD11604394 details
PAK1_HUMANHGS_HUMANBioGRID, HPRD11397816 details
PAK1_HUMANNCK1_HUMANBioGRID, HPRD10026169 10330411 10372803 11157752 11278241 11557983 8824201 9851874 details
PAK1_HUMANMYLK_HUMANBioGRID, HPRD10092231 details
PAK1_HUMANBAIP2_HUMANBioGRID11130076 details
PAK1_HUMANBMX_HUMANBioGRID, HPRD11382770 details
PAK1_HUMANH4_HUMANBioGRID, HPRD15864311 details
PAK1_HUMANELF3_HUMANBioGRID17491012 details
PAK1_HUMANM3K1_HUMANBioGRID12228228 details
PAK1_HUMANMYO6_HUMANBioGRID9852149 details
PAK1_HUMANTGFR1_HUMANBioGRID, HPRD15761153 details
PAK1_HUMANTGFR2_HUMANBioGRID, HPRD15761153 details
PAK1_HUMANA4_HUMANBioGRID21832049 details
PAK1_HUMANCHRD1_HUMANBioGRID19910486 details
PAK1_HUMANESR1_HUMANBioGRID, HPRD12374744 16452229 details
PAK1_HUMANBAD_HUMANBioGRID, HPRD10611223 15784622 15849194 16413544 19667065 details
PAK1_HUMANH31_HUMANBioGRID12151336 details
PAK1_HUMANBRSK1_HUMANBioGRID22669945 details
PAK1_HUMANPPM1A_HUMANBioGRID18586681 details
PAK1_HUMANPP2AA_HUMANBioGRID18586681 details
PAK1_HUMANPP1A_HUMANBioGRID18586681 details
PAK1_HUMANHACE1_HUMANBioGRID29362425 details
PAK1_HUMANGRB2_HUMANBioGRID, HPRD12522133 details
PAK1_HUMANOXSR1_HUMANHPRD14707132 details
PAK1_HUMANGIT1_HUMANBioGRID, IntAct, MINT16628223 23455922 25852190 31980649 details
PAK1_HUMANGIT2_HUMANBioGRID, HPRD, IntAct, MINT11157752 16628223 25852190 31980649 details
PAK1_HUMANATG5_HUMANIntAct17353931 details
PAK1_HUMANIKKE_HUMANIntAct17353931 details
PAK1_HUMANSH3K1_HUMANBioGRID, MINT16407834 details
PAK1_HUMANPLK1_HUMANMINT20869364 details
PAK1_HUMANMERL_HUMANHPRD, IntAct11719502 14580336 21481793 details
PAK1_HUMANRAC2_HUMANmbinfo14521508 details
PAK1_HUMANRAC3_HUMANmbinfo14521508 details
PAK1_HUMANRHOQ_HUMANmbinfo14521508 details
PAK1_HUMANCIB1_HUMANmbinfo16061695 details
PAK1_HUMANASC_HUMANBioGRID, IntAct25402006 details
PAK1_HUMANPAXI_HUMANBioGRID, HPRD, IntAct10330411 31980649 details
PAK1_HUMANERBB2_HUMANBioGRID, HPRD9774445 details
PAK1_HUMANKPYR_HUMANBioGRID12006652 details
PAK1_HUMANGBB1_HUMANBioGRID12887923 details
PAK1_HUMANTF65_HUMANBioGRID26036343 details
PAK1_HUMANMK14_HUMANBioGRID18586681 details
PAK1_HUMANWDR26_HUMANBioGRID27835684 details
PAK1_HUMANGDIR1_HUMANBioGRID27835684 details
PAK1_HUMANMP2K1_HUMANHPRD9351825 details
PAK1_HUMANCD5R1_HUMANHPRD11604394 details
PAK1_HUMANPDPK1_HUMANHPRD10995762 details
PAK1_HUMANFOXL2_HUMANHPRD12560069 details
PAK1_HUMANPPM1F_HUMANHPRD11864573 details
PAK1_HUMANCSK21_HUMANHPRD10938077 details
PAK1_HUMANCSK22_HUMANHPRD10938077 details
PAK1_HUMANMK01_HUMANHPRD15542607 details
PAK1_HUMANACVR1_HUMANHPRD15761153 details
PAK1_HUMANBMR1B_HUMANHPRD15761153 details
PAK1_HUMANSMAD1_HUMANHPRD15761153 details
PAK1_HUMANSMAD2_HUMANHPRD15761153 details
PAK1_HUMANSMAD4_HUMANHPRD15761153 details
PAK1_HUMANSMUF1_HUMANHPRD15761153 details
PAK1_HUMANSYN1_HUMANHPRD12237306 details
PAK1_HUMANDSCAM_HUMANHPRD15169762 details
PAK1_HUMANCO1A1_HUMANHPRD10772928 details
PAK1_HUMANKPCD_HUMANHPRD16033904 details
PAK1_HUMANACTS_HUMANHPRD9298982 details
PAK1_HUMANMBP_HUMANHPRD14579272 details
PAK1_HUMANNCF1_HUMANHPRD12855698 details
PAK1_HUMANFRS2_HUMANHPRD12154000 details
PAK1_HUMANSRBS2_HUMANHPRD15784622 details
PAK1_HUMANSHC1_HUMANHPRD15688026 details
PAK1_HUMANFOXO1_HUMANHPRD10358014 12560069 details
PAK1_HUMANCASP1_HUMANHPRD15561713 details