Entity Details

Primary name CR1
Entity type gene
Source Source Link

Details

PrimaryID1378
RefseqGeneNG_007481
SymbolCR1
Namecomplement C3b/C4b receptor 1 (Knops blood group)
Chromosome1
Location1q32.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-14
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsCR1_HUMAN

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001851 complement component C3b binding
GO:0001855 complement component C4b binding
GO:0001861 complement component C4b receptor activity
GO:0001970 positive regulation of activation of membrane attack complex
GO:0001971 negative regulation of activation of membrane attack complex
GO:0002430 complement receptor mediated signaling pathway
GO:0002435 immune complex clearance by erythrocytes
GO:0002638 negative regulation of immunoglobulin production
GO:0004877 complement component C3b receptor activity
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0007009 plasma membrane organization
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0030449 regulation of complement activation
GO:0030667 secretory granule membrane
GO:0032689 negative regulation of interferon-gamma production
GO:0032703 negative regulation of interleukin-2 production
GO:0042130 negative regulation of T cell proliferation
GO:0043312 neutrophil degranulation
GO:0044853 plasma membrane raft
GO:0045589 regulation of regulatory T cell differentiation
GO:0045591 positive regulation of regulatory T cell differentiation
GO:0045916 negative regulation of complement activation
GO:0045918 negative regulation of cytolysis
GO:0045957 negative regulation of complement activation, alternative pathway
GO:0045959 negative regulation of complement activation, classical pathway
GO:0070062 extracellular exosome
GO:0101003 ficolin-1-rich granule membrane
GO:1900004 negative regulation of serine-type endopeptidase activity
GO:1900005 positive regulation of serine-type endopeptidase activity
GO:1900099 negative regulation of plasma cell differentiation
GO:1904669 ATP export

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
CR1C3HPRD, IntAct10382758 18796626 9988761 details
CR1CR2BioGRID, HPRD1708808 7690834 details
CR1C1QAHPRD10528211 details
CR1C4AHPRD8422437 details
CR1CD55HPRD11694537 details
CR1FUT4HPRD3305706 details