Entity Details

Primary name ADAM9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13443
EntryNameADAM9_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 9
TaxID9606
Evidenceevidence at protein level
Length819
SequenceStatuscomplete
DateCreated2002-10-19
DateModified2021-06-02

Ontological Relatives

GenesADAM9

GO terms

Show/Hide Table
GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0004222 metalloendopeptidase activity
GO:0005080 protein kinase C binding
GO:0005178 integrin binding
GO:0005518 collagen binding
GO:0005615 extracellular space
GO:0005925 focal adhesion
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008237 metallopeptidase activity
GO:0009986 cell surface
GO:0010042 response to manganese ion
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0016485 protein processing
GO:0017124 SH3 domain binding
GO:0030216 keratinocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031233 intrinsic component of external side of plasma membrane
GO:0031293 membrane protein intracellular domain proteolysis
GO:0033627 cell adhesion mediated by integrin
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034241 positive regulation of macrophage fusion
GO:0034612 response to tumor necrosis factor
GO:0042117 monocyte activation
GO:0042542 response to hydrogen peroxide
GO:0042987 amyloid precursor protein catabolic process
GO:0043236 laminin binding
GO:0046872 metal ion binding
GO:0050714 positive regulation of protein secretion
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051384 response to glucocorticoid
GO:0051549 positive regulation of keratinocyte migration
GO:0051592 response to calcium ion
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR006586 ADAM, cysteine-rich domainDomainDomain
IPR018358 Disintegrin, conserved siteSiteConserved site
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR034027 Reprolysin domain, adamalysin-typeDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
612775 OMIMCone-rod dystrophy 9 (CORD9)An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB05033 INCB7839Drugbanksmall molecule