Entity Details

Primary name PICAL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13492
EntryNamePICAL_HUMAN
FullNamePhosphatidylinositol-binding clathrin assembly protein
TaxID9606
Evidenceevidence at protein level
Length652
SequenceStatuscomplete
DateCreated2002-11-15
DateModified2021-06-02

Ontological Relatives

GenesPICALM

GO terms

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GOName
GO:0000149 SNARE binding
GO:0001540 amyloid-beta binding
GO:0005545 1-phosphatidylinositol binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006900 vesicle budding from membrane
GO:0007409 axonogenesis
GO:0007611 learning or memory
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0016188 synaptic vesicle maturation
GO:0016192 vesicle-mediated transport
GO:0016197 endosomal transport
GO:0030097 hemopoiesis
GO:0030100 regulation of endocytosis
GO:0030136 clathrin-coated vesicle
GO:0030276 clathrin binding
GO:0031224 intrinsic component of membrane
GO:0031267 small GTPase binding
GO:0031623 receptor internalization
GO:0031982 vesicle
GO:0032050 clathrin heavy chain binding
GO:0032880 regulation of protein localization
GO:0035459 vesicle cargo loading
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0043231 intracellular membrane-bounded organelle
GO:0043547 positive regulation of GTPase activity
GO:0045211 postsynaptic membrane
GO:0045296 cadherin binding
GO:0045334 clathrin-coated endocytic vesicle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048156 tau protein binding
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048268 clathrin coat assembly
GO:0048471 perinuclear region of cytoplasm
GO:0048813 dendrite morphogenesis
GO:0050750 low-density lipoprotein particle receptor binding
GO:0055072 iron ion homeostasis
GO:0061024 membrane organization
GO:0065003 protein-containing complex assembly
GO:0070381 endosome to plasma membrane transport vesicle
GO:0072583 clathrin-dependent endocytosis
GO:0090647 modulation of age-related behavioral decline
GO:0097418 neurofibrillary tangle
GO:0097494 regulation of vesicle size
GO:0097753 membrane bending
GO:0098894 extrinsic component of presynaptic endocytic zone membrane
GO:0150093 amyloid-beta clearance by transcytosis
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of amyloid-beta formation
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903077 negative regulation of protein localization to plasma membrane
GO:1905224 clathrin-coated pit assembly
GO:2000009 negative regulation of protein localization to cell surface

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Golgi apparatus
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR008942 ENTH/VHSFamilyHomologous superfamily
IPR011417 AP180 N-terminal homology (ANTH) domainDomainDomain
IPR013809 ENTH domainDomainDomain
IPR014712 ANTH domain superfamilyFamilyHomologous superfamily
IPR030412 Phosphatidylinositol-binding clathrin assembly proteinFamilyFamily

Diseases

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Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
PICAL_HUMANPELI2_HUMANBioGRID, IntAct21988832 details
PICAL_HUMANCLH1_HUMANBioGRID, HPRD, IntAct10436022 26496610 details
PICAL_HUMANCRX_HUMANBioGRID, IntAct27107012 details
PICAL_HUMANRBPMS_HUMANBioGRID, IntAct27107012 details
PICAL_HUMANATX1L_HUMANBioGRID, IntAct32296183 details
PICAL_HUMANATX1_HUMANBioGRID, IntAct32296183 details
PICAL_HUMANZC3HA_HUMANBioGRID, IntAct32296183 details
PICAL_HUMANFHL2_HUMANMINT22829078 details
PICAL_HUMANPLCG1_HUMANBioGRID, HPRD10926122 details
PICAL_HUMANITSN1_HUMANBioGRID22558309 details
PICAL_HUMANSMUF1_HUMANBioGRID20804422 details
PICAL_HUMANFCHO1_HUMANBioGRID27237791 details
PICAL_HUMANTEN1_HUMANBioGRID25648896 details
PICAL_HUMANCDC42_HUMANBioGRID31478661 details
PICAL_HUMANOGT1_HUMANBioGRID32994395 details
PICAL_HUMANCLH2_HUMANBioGRID, HPRD, IntAct10436022 26496610 28514442 details
PICAL_HUMANMYO6_HUMANBioGRID, IntAct26496610 26950368 29467281 details
PICAL_HUMANAP2A1_HUMANBioGRID, HPRD, IntAct10436022 22939629 28514442 details
PICAL_HUMANSCG1_HUMANIntAct31413325 details
PICAL_HUMANEPN2_HUMANIntAct31413325 details
PICAL_HUMANSNX33_HUMANIntAct31413325 details
PICAL_HUMANZN521_HUMANIntAct31413325 details
PICAL_HUMANANK3_HUMANIntAct31413325 details
PICAL_HUMANANK2_HUMANIntAct31413325 details
PICAL_HUMANBAZ2B_HUMANIntAct31413325 details
PICAL_HUMANEPN1_HUMANIntAct31413325 details
PICAL_HUMANNECA1_HUMANIntAct31413325 details
PICAL_HUMANRU17_HUMANIntAct31413325 details
PICAL_HUMANMIPT3_HUMANIntAct31413325 details
PICAL_HUMANSIR1_HUMANBioGRID23382074 details
PICAL_HUMANITA4_HUMANBioGRID22623428 details
PICAL_HUMANMLP3A_HUMANBioGRID24067654 details
PICAL_HUMANSMAP2_HUMANBioGRID29395067 details
PICAL_HUMANISG15_HUMANBioGRID33024031 details
PICAL_HUMANCASP3_HUMANHPRD10926122 details
PICAL_HUMANCASP8_HUMANHPRD10926122 details
PICAL_HUMANEHD2_HUMANHPRD15182197 details
PICAL_HUMANDDIT3_HUMANHPRD1547942 details