Entity Details

Primary name DGKZ_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13574
EntryNameDGKZ_HUMAN
FullNameDiacylglycerol kinase zeta
TaxID9606
Evidenceevidence at protein level
Length928
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDGKZ

GO terms

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GOName
GO:0001727 lipid kinase activity
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006654 phosphatidic acid biosynthetic process
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0008022 protein C-terminus binding
GO:0014069 postsynaptic density
GO:0016301 kinase activity
GO:0016477 cell migration
GO:0016607 nuclear speck
GO:0030027 lamellipodium
GO:0030168 platelet activation
GO:0031571 mitotic G1 DNA damage checkpoint signaling
GO:0035556 intracellular signal transduction
GO:0045930 negative regulation of mitotic cell cycle
GO:0046339 diacylglycerol metabolic process
GO:0046486 glycerolipid metabolic process
GO:0046834 lipid phosphorylation
GO:0046872 metal ion binding
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0090216 positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0098978 glutamatergic synapse

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000756 Diacylglycerol kinase, accessory domainDomainDomain
IPR001206 Diacylglycerol kinase, catalytic domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamilyFamilyHomologous superfamily
IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminalFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily
IPR037607 Diacylglycerol kinaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule