Entity Details

Primary name ABCA2
Entity type gene
Source Source Link

Details

PrimaryID20
RefseqGeneNG_011789
SymbolABCA2
NameATP binding cassette subfamily A member 2
Chromosome9
Location9q34.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-30
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsABCA2_HUMAN

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0001573 ganglioside metabolic process
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006629 lipid metabolic process
GO:0006684 sphingomyelin metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006869 lipid transport
GO:0007626 locomotory behavior
GO:0010008 endosome membrane
GO:0010872 regulation of cholesterol esterification
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016887 ATP hydrolysis activity
GO:0031410 cytoplasmic vesicle
GO:0032289 central nervous system myelin formation
GO:0032383 regulation of intracellular cholesterol transport
GO:0032384 negative regulation of intracellular cholesterol transport
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0042493 response to drug
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0043231 intracellular membrane-bounded organelle
GO:0046512 sphingosine biosynthetic process
GO:0048545 response to steroid hormone
GO:0055085 transmembrane transport
GO:0060049 regulation of protein glycosylation
GO:0061135 endopeptidase regulator activity
GO:0070723 response to cholesterol
GO:0071072 negative regulation of phospholipid biosynthetic process
GO:0090155 negative regulation of sphingolipid biosynthetic process
GO:0090156 cellular sphingolipid homeostasis
GO:0090370 negative regulation of cholesterol efflux
GO:0099038 ceramide floppase activity
GO:0099040 ceramide translocation
GO:0150104 transport across blood-brain barrier
GO:0150110 negative regulation of cholesterol esterification
GO:1901873 regulation of post-translational protein modification
GO:1902004 positive regulation of amyloid-beta formation
GO:1902993 positive regulation of amyloid precursor protein catabolic process
GO:1904375 regulation of protein localization to cell periphery
GO:1905598 negative regulation of low-density lipoprotein receptor activity
GO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport
GO:2000008 regulation of protein localization to cell surface

Diseases

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Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
ABCA2CDK5RAP2BioGRID, HPRD, IntAct12421765 details
ABCA2CACNA1ABioGRID, IntAct21078624 details
ABCA2DRD2BioGRID, MINT28298427 details
ABCA2HTR6BioGRID, MINT28298427 details
ABCA2YWHAHBioGRID, IntAct26496610 details
ABCA2CLTCBioGRID, IntAct26496610 details
ABCA2GPATCH8BioGRID, IntAct26496610 details
ABCA2MYCBioGRID, IntAct26496610 details
ABCA2RNASEH2BBioGRID, IntAct26496610 details
ABCA2RAB32BioGRID, IntAct26496610 details
ABCA2PCDH1BioGRID, IntAct26496610 details
ABCA2TMEM248BioGRID, IntAct26496610 details
ABCA2LAMB3BioGRID, IntAct26496610 details
ABCA2PMS2BioGRID, IntAct26496610 details
ABCA2SDHAF2BioGRID, IntAct26496610 details
ABCA2ZNRF4BioGRID, IntAct28514442 details
ABCA2PTCH1BioGRID, IntAct26186194 28514442 details
ABCA2HTR3ABioGRID, IntAct28514442 details
ABCA2PON2BioGRID, IntAct26186194 28514442 details
ABCA2LMAN2LBioGRID, IntAct28514442 details
ABCA2NEK4BioGRID, MINT25798074 details
ABCA2AGR2BioGRID30575818 details
ABCA2RECQL4BioGRID29229926 details
ABCA2KIF14BioGRID31586073 details
ABCA2FBXO6BioGRID32409323 details
ABCA2NXF1BioGRID22658674 details