Entity Details

Primary name EPHA4
Entity type gene
Source Source Link

Details

PrimaryID2043
RefseqGene
SymbolEPHA4
NameEPH receptor A4
Chromosome2
Location2q36.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsEPHA4_HUMAN

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0004672 protein kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005912 adherens junction
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0007628 adult walking behavior
GO:0008045 motor neuron axon guidance
GO:0008347 glial cell migration
GO:0009986 cell surface
GO:0010977 negative regulation of neuron projection development
GO:0016301 kinase activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021957 corticospinal tract morphogenesis
GO:0030175 filopodium
GO:0030336 negative regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0031901 early endosome membrane
GO:0033674 positive regulation of kinase activity
GO:0034332 adherens junction organization
GO:0042731 PH domain binding
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043087 regulation of GTPase activity
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043235 receptor complex
GO:0043507 positive regulation of JUN kinase activity
GO:0043679 axon terminus
GO:0044295 axonal growth cone
GO:0045785 positive regulation of cell adhesion
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0048681 negative regulation of axon regeneration
GO:0048710 regulation of astrocyte differentiation
GO:0050770 regulation of axonogenesis
GO:0050775 positive regulation of dendrite morphogenesis
GO:0050821 protein stabilization
GO:0061001 regulation of dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0072178 nephric duct morphogenesis
GO:0090102 cochlea development
GO:0097155 fasciculation of sensory neuron axon
GO:0097156 fasciculation of motor neuron axon
GO:0097161 DH domain binding
GO:0097485 neuron projection guidance
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098839 postsynaptic density membrane
GO:0098883 synapse pruning
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0106030 neuron projection fasciculation
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1902004 positive regulation of amyloid-beta formation
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1904646 cellular response to amyloid-beta
GO:1905244 regulation of modification of synaptic structure
GO:1990782 protein tyrosine kinase binding
GO:2001108 positive regulation of Rho guanyl-nucleotide exchange factor activity

Diseases

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Interactions

95 interactions

InteractorPartnerSourcesPublicationsLink
EPHA4IKBKGBioGRID, IntAct20098747 details
EPHA4EFNB3BioGRID, DIP, HPRD, IntAct12383247 23812375 28514442 9484836 details
EPHA4EFNB2DIP, HPRD12761826 19836338 details
EPHA4EFNA2DIP19836338 details
EPHA4EFNA5DIP, HPRD19836338 23812375 8755474 details
EPHA4EFNA1BioGRID, DIP, HPRD10366629 19836338 8755474 details
EPHA4EFNA4DIP, HPRD10366629 19836338 details
EPHA4EPHA4DIP, HPRD23812375 8622893 details
EPHA4TNS3BioGRID, MINT28065597 details
EPHA4NGEFBioGRID, HPRD11336673 details
EPHA4SRCBioGRID9632142 details
EPHA4FGFR1BioGRID, HPRD16365308 18790757 details
EPHA4FGFR3BioGRID, HPRD16365308 details
EPHA4ERBB2BioGRID30898150 details
EPHA4HSP90AB1IntAct22939624 details
EPHA4ACOT7IntAct31413325 details
EPHA4PNCKIntAct31413325 details
EPHA4FYNBioGRID, HPRD, IntAct12084815 31413325 details
EPHA4ZNF521IntAct31413325 details
EPHA4SIPA1L1IntAct31413325 details
EPHA4ABL2IntAct31413325 details
EPHA4GLRBIntAct31413325 details
EPHA4JAKMIP3IntAct31413325 details
EPHA4GRB10IntAct31413325 details
EPHA4MFAP1IntAct31413325 details
EPHA4TRIM37IntAct31413325 details
EPHA4NCLIntAct31413325 details
EPHA4PAX6IntAct31413325 details
EPHA4ATP6V1HIntAct31413325 details
EPHA4PLCG2IntAct31413325 details
EPHA4PLCG1IntAct31413325 details
EPHA4PLAG1IntAct31413325 details
EPHA4PIK3R1IntAct31413325 details
EPHA4RASA1IntAct31413325 details
EPHA4SNRNP70IntAct31413325 details
EPHA4STAT5BIntAct31413325 details
EPHA4VAV2IntAct31413325 details
EPHA4SLBPIntAct31413325 details
EPHA4ARHGAP39IntAct31413325 details
EPHA4KIAA1755IntAct31413325 details
EPHA4LNX1IntAct31413325 details
EPHA4MVB12BIntAct31413325 details
EPHA4TSPOAP1IntAct31413325 details
EPHA4OPALINIntAct31413325 details
EPHA4NR1D1IntAct31413325 details
EPHA4GPRASP1IntAct31413325 details
EPHA4NR1D2IntAct31413325 details
EPHA4MAGI2IntAct31413325 details
EPHA4ARHGEF15BioGRID, HPRD12775584 details
EPHA4ANAPC2BioGRID21186356 details
EPHA4FZR1BioGRID21186356 details
EPHA4FGFR2BioGRID16365308 details
EPHA4FGFR4BioGRID, HPRD16365308 details
EPHA4FRS2BioGRID16365308 details
EPHA4EFNA3HPRD12496762 details
EPHA4KLRG2BioGRID, IntAct28514442 details
EPHA4TSPAN3BioGRID, IntAct26186194 28514442 details
EPHA4GNAZBioGRID, IntAct26186194 28514442 details
EPHA4EPHA7BioGRID, IntAct28514442 details
EPHA4SLC1A1BioGRID, IntAct28514442 details
EPHA4OS9BioGRID, IntAct28514442 details
EPHA4CPA5BioGRID, IntAct28514442 details
EPHA4CYP1A2BioGRID, IntAct28514442 details
EPHA4MMP26BioGRID, IntAct28514442 details
EPHA4GPN3BioGRID, IntAct26186194 28514442 details
EPHA4TUBBBioGRID, IntAct28514442 details
EPHA4ARMC6BioGRID, IntAct28514442 details
EPHA4IARS2BioGRID, IntAct28514442 details
EPHA4HDAC10BioGRID, IntAct28514442 details
EPHA4TBC1D22ABioGRID, IntAct26186194 28514442 details
EPHA4RFC4BioGRID, IntAct28514442 details
EPHA4TUBB2BBioGRID, IntAct26186194 28514442 details
EPHA4RIPK3BioGRID, IntAct26186194 28514442 details
EPHA4FABP1BioGRID, IntAct28514442 details
EPHA4CEACAM21BioGRID, IntAct26186194 28514442 details
EPHA4RSPH14BioGRID, IntAct28514442 details
EPHA4FAM118BBioGRID, IntAct28514442 details
EPHA4GBP5BioGRID, IntAct28514442 details
EPHA4UMPSBioGRID, IntAct28514442 details
EPHA4BET1BioGRID, IntAct29568061 details
EPHA4TGOLN2BioGRID, IntAct29568061 details
EPHA4RYKBioGRID21875946 details
EPHA4VHLBioGRID21942715 details
EPHA4HSP90AA1BioGRID22939624 details
EPHA4HLA-DPA1BioGRID26186194 details
EPHA4GNAT2BioGRID26186194 details
EPHA4ESR2BioGRID29509190 details
EPHA4HRASBioGRID30639242 details
EPHA4KRASBioGRID30639242 34079125 details
EPHA4CAV1BioGRID34079125 details
EPHA4GJA1BioGRID34079125 details
EPHA4LAMP1BioGRID34079125 details
EPHA4LYNBioGRID34079125 details
EPHA4OCLNBioGRID34079125 details
EPHA4MKRN2BioGRID32460013 details