Entity Details

Primary name HEY2
Entity type gene
Source Source Link

Details

PrimaryID23493
RefseqGene
SymbolHEY2
Namehes related family bHLH transcription factor with YRPW motif 2
Chromosome6
Location6q22.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsHEY2_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001570 vasculogenesis
GO:0003150 muscular septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003161 cardiac conduction system development
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003195 tricuspid valve formation
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0008134 transcription factor binding
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0010460 positive regulation of heart rate
GO:0010621 negative regulation of transcription by transcription factor localization
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014031 mesenchymal cell development
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0017053 transcription repressor complex
GO:0035910 ascending aorta morphogenesis
GO:0035912 dorsal aorta morphogenesis
GO:0036304 umbilical cord morphogenesis
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045607 regulation of inner ear auditory receptor cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0050767 regulation of neurogenesis
GO:0051145 smooth muscle cell differentiation
GO:0055015 ventricular cardiac muscle cell development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060347 heart trabecula formation
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter
GO:0060716 labyrinthine layer blood vessel development
GO:0060842 arterial endothelial cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060977 coronary vasculature morphogenesis
GO:0061156 pulmonary artery morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0065004 protein-DNA complex assembly
GO:0070168 negative regulation of biomineral tissue development
GO:0072359 circulatory system development
GO:0090102 cochlea development
GO:0097084 vascular associated smooth muscle cell development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2000723 negative regulation of cardiac vascular smooth muscle cell differentiation
GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212 regulation of vasculogenesis

Diseases

Show/Hide Table

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
HEY2PLSCR1BioGRID, HPRD, IntAct16189514 details
HEY2SIRT1BioGRID, HPRD, UniProt12535671 details
HEY2ENO1BioGRID, IntAct23414517 details
HEY2ATXN1BioGRID, IntAct23275563 details
HEY2HTTBioGRID, IntAct23275563 details
HEY2TRAF1BioGRID, IntAct25416956 32296183 details
HEY2RBPMSBioGRID, IntAct25416956 details
HEY2PDLIM7BioGRID, IntAct32296183 details
HEY2KRTAP6-2BioGRID, IntAct32296183 details
HEY2CYSRT1BioGRID, IntAct32296183 details
HEY2KRTAP4-4BioGRID, IntAct32296183 details
HEY2KRTAP1-1BioGRID, IntAct32296183 details
HEY2KRTAP5-9BioGRID, IntAct32296183 details
HEY2HSF2BPBioGRID, IntAct32296183 details
HEY2TRAF4BioGRID, IntAct32296183 details
HEY2KRTAP6-1BioGRID, IntAct32296183 details
HEY2KRTAP3-1BioGRID, IntAct32296183 details
HEY2FHL5BioGRID, IntAct32296183 details
HEY2KRTAP8-1BioGRID, IntAct32296183 details
HEY2KRTAP11-1BioGRID, IntAct32296183 details
HEY2HOXA1BioGRID, IntAct32296183 details
HEY2HEY1BioGRID, IntAct19802006 24366871 26186194 27129302 28514442 details
HEY2HAND1BioGRID, HPRD10924525 details
HEY2NCOR1BioGRID, HPRD11486045 details
HEY2HDAC1BioGRID, HPRD11486045 details
HEY2HES1BioGRID, HPRD11486045 details
HEY2ARNTBioGRID, HPRD10692439 details
HEY2ASXL1BioGRID32683582 details
HEY2HAND2HPRD10924525 details
HEY2HDAC9BioGRID11486045 details
HEY2SIN3ABioGRID, HPRD11486045 details
HEY2CASP3BioGRID17217622 details
HEY2BTRCBioGRID17217622 details
HEY2SYVN1BioGRID24366871 details
HEY2SEL1LBioGRID24366871 details
HEY2DERL2BioGRID24366871 details
HEY2FBXO45BioGRID26068074 details
HEY2HEY2HPRD11486045 details
HEY2CHMP1ABioGRID, IntAct28514442 details
HEY2ARL10BioGRID, IntAct26186194 28514442 details
HEY2CARM1BioGRID, IntAct26186194 28514442 details
HEY2IST1BioGRID, IntAct26186194 28514442 details
HEY2CCL5IntAct33179750 details
HEY2CX3CL1IntAct33179750 details
HEY2IL12AIntAct33179750 details
HEY2IL34IntAct33179750 details
HEY2IL7IntAct33179750 details
HEY2PPBPIntAct33179750 details
HEY2TNFSF12IntAct33179750 details
HEY2TNFSF14IntAct33179750 details
HEY2TNFSF8IntAct33179750 details
HEY2XCL1IntAct33179750 details