Entity Details

Primary name ALOX12
Entity type gene
Source Source Link

Details

PrimaryID239
RefseqGene
SymbolALOX12
Namearachidonate 12-lipoxygenase, 12S type
Chromosome17
Location17p13.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsLOX12_HUMAN

GO terms

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GOName
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0007568 aging
GO:0010628 positive regulation of gene expression
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0016020 membrane
GO:0016165 linoleate 13S-lipoxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0019395 fatty acid oxidation
GO:0033559 unsaturated fatty acid metabolic process
GO:0034440 lipid oxidation
GO:0042383 sarcolemma
GO:0042554 superoxide anion generation
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043651 linoleic acid metabolic process
GO:0047977 hepoxilin-epoxide hydrolase activity
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050473 arachidonate 15-lipoxygenase activity
GO:0051121 hepoxilin metabolic process
GO:0051122 hepoxilin biosynthetic process
GO:0051901 positive regulation of mitochondrial depolarization
GO:0061436 establishment of skin barrier
GO:0070062 extracellular exosome
GO:0071396 cellular response to lipid
GO:0090331 negative regulation of platelet aggregation
GO:1901751 leukotriene A4 metabolic process
GO:1905956 positive regulation of endothelial tube morphogenesis
GO:2001301 lipoxin biosynthetic process
GO:2001303 lipoxin A4 biosynthetic process
GO:2001306 lipoxin B4 biosynthetic process

Diseases

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Interactions

11 interactions

InteractorPartnerSourcesPublicationsLink
ALOX12KRT5BioGRID, HPRD, IntAct10727209 details
ALOX12LMNABioGRID, HPRD, IntAct10727209 details
ALOX12ITGB4BioGRID, HPRD, IntAct10727209 26037302 details
ALOX12TRIB1BioGRID, HPRD, IntAct10727209 details
ALOX12ALOX12BioGRID18155727 details
ALOX12KRT85HPRD10727209 details
ALOX12PLA2G2ABioGRID, HPRD, MINT15474031 details
ALOX12ACTA2BioGRID17379189 details
ALOX12PLA2G4ABioGRID15474031 details
ALOX12KAT5HPRD15474031 details
ALOX12HNRNPH1BioGRID26760575 details