Entity Details

Primary name ALOX5
Entity type gene
Source Source Link

Details

PrimaryID240
RefseqGeneNG_011437
SymbolALOX5
Namearachidonate 5-lipoxygenase
Chromosome10
Location10q11.21
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsLOX5_HUMAN

GO terms

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GOName
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002540 leukotriene production involved in inflammatory response
GO:0004051 arachidonate 5-lipoxygenase activity
GO:0004052 arachidonate 12(S)-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005635 nuclear envelope
GO:0005641 nuclear envelope lumen
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006691 leukotriene metabolic process
GO:0006959 humoral immune response
GO:0016363 nuclear matrix
GO:0016525 negative regulation of angiogenesis
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016787 hydrolase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019372 lipoxygenase pathway
GO:0030501 positive regulation of bone mineralization
GO:0031965 nuclear membrane
GO:0034440 lipid oxidation
GO:0034774 secretory granule lumen
GO:0035655 interleukin-18-mediated signaling pathway
GO:0036336 dendritic cell migration
GO:0036403 arachidonate 8(S)-lipoxygenase activity
GO:0042593 glucose homeostasis
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043312 neutrophil degranulation
GO:0043651 linoleic acid metabolic process
GO:0045598 regulation of fat cell differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0051122 hepoxilin biosynthetic process
GO:0061044 negative regulation of vascular wound healing
GO:0061045 negative regulation of wound healing
GO:0106014 regulation of inflammatory response to wounding
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900407 regulation of cellular response to oxidative stress
GO:1901753 leukotriene A4 biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1903671 negative regulation of sprouting angiogenesis
GO:1904813 ficolin-1-rich granule lumen
GO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell
GO:2001301 lipoxin biosynthetic process

Diseases

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Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
ALOX5COTL1BioGRID, DIP, HPRD, UniProt10051563 11297527 16924104 19579006 19807693 25034252 details
ALOX5MAPKAPK2BioGRID, HPRD, MINT10779545 11844797 24860872 details
ALOX5YES1MINT24860872 details
ALOX5PRKACAMINT24860872 details
ALOX5HCKMINT24860872 details
ALOX5FGRMINT24860872 details
ALOX5CAMK2GMINT24860872 details
ALOX5MEOX1BioGRID, IntAct25416956 details
ALOX5RELBioGRID, IntAct25416956 details
ALOX5HHIPL2BioGRID, IntAct25416956 25910212 details
ALOX5NUTM1BioGRID, IntAct25416956 31515488 32296183 details
ALOX5CEP57L1BioGRID, IntAct25416956 25910212 details
ALOX5SYCE1BioGRID, IntAct25416956 25910212 details
ALOX5CEP63BioGRID, IntAct25416956 25910212 31515488 32296183 details
ALOX5MAD1L1BioGRID, IntAct25416956 25910212 32296183 details
ALOX5LCN1BioGRID, IntAct32296183 details
ALOX5TBC1D7-LOC100130357IntAct32296183 details
ALOX5TBC1D7BioGRID, IntAct32296183 details
ALOX5HSD17B1BioGRID, IntAct32296183 details
ALOX5OOEPBioGRID, IntAct32296183 details
ALOX5CCDC174BioGRID, IntAct32296183 details
ALOX5C10orf67BioGRID, IntAct32296183 details
ALOX5GATCBioGRID, IntAct32296183 details
ALOX5SPRED1IntAct32814053 details
ALOX5TGFBRAP1BioGRID, HPRD10051563 details
ALOX5GRB2BioGRID, HPRD7929073 8585605 details
ALOX5APPBioGRID21832049 details
ALOX5LTC4SBioGRID19233132 details
ALOX5ALOX5APBioGRID, HPRD19233132 26327594 26396238 9445303 details
ALOX5DICER1BioGRID10051563 19022417 details
ALOX5ALPLBioGRID26210919 details
ALOX5MEOX2BioGRID32296183 details
ALOX5PIK3R1BioGRID21200133 details
ALOX5RELABioGRID9681993 details
ALOX5ACTBHPRD7929073 details
ALOX5ITSN1BioGRID, IntAct28514442 details
ALOX5DDHD2BioGRID, IntAct28514442 details
ALOX5NEU3BioGRID, IntAct28514442 details
ALOX5TBC1D2BBioGRID, IntAct28514442 details
ALOX5MTMR4BioGRID, IntAct28514442 details
ALOX5OSBPL11BioGRID, IntAct28514442 details
ALOX5MND1BioGRID, IntAct28514442 details
ALOX5CAMKK2BioGRID, IntAct28514442 details
ALOX5KIF16BBioGRID, IntAct28514442 details
ALOX5PNPLA2BioGRID, IntAct28514442 details
ALOX5PSMF1BioGRID, IntAct28514442 details
ALOX5MADDBioGRID, IntAct28514442 details
ALOX5SLAIN1BioGRID, IntAct28514442 details
ALOX5PALS1BioGRID, IntAct28514442 details
ALOX5AMOTL1BioGRID, IntAct28514442 details
ALOX5TEDC1BioGRID, IntAct28514442 details
ALOX5ERMP1BioGRID, IntAct28514442 details
ALOX5KDM3BBioGRID, IntAct28514442 details
ALOX5TRIM65BioGRID, IntAct28514442 details
ALOX5ARMCX5BioGRID, IntAct28514442 details
ALOX5PMF1-BGLAPIntAct28514442 details
ALOX5PMF1BioGRID, IntAct28514442 details
ALOX5AMOTBioGRID, IntAct28514442 details
ALOX5ERCC6LBioGRID, IntAct28514442 details
ALOX5RPS6KA2BioGRID, IntAct28514442 details
ALOX5RAB3GAP1BioGRID, IntAct28514442 details
ALOX5COG2BioGRID, IntAct28514442 details
ALOX5CKAP5BioGRID, IntAct28514442 details
ALOX5MTMR3BioGRID, IntAct28514442 details
ALOX5CDC16BioGRID, IntAct28514442 details
ALOX5DMWDBioGRID, IntAct28514442 details
ALOX5NFKB2BioGRID, IntAct28514442 details
ALOX5LSSBioGRID, IntAct28514442 details
ALOX5ADSLBioGRID, IntAct28514442 details
ALOX5TPP2BioGRID, IntAct28514442 details
ALOX5NCSTNBioGRID, IntAct28514442 details
ALOX5RNF6BioGRID, IntAct28514442 details
ALOX5RNF123BioGRID29676528 details
ALOX5MTDHBioGRID22199357 details