Entity Details

Primary name SCN5A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14524
EntryNameSCN5A_HUMAN
FullNameSodium channel protein type 5 subunit alpha
TaxID9606
Evidenceevidence at protein level
Length2016
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesSCN5A

GO terms

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GOName
GO:0001518 voltage-gated sodium channel complex
GO:0002027 regulation of heart rate
GO:0003161 cardiac conduction system development
GO:0003231 cardiac ventricle development
GO:0003360 brainstem development
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005516 calmodulin binding
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006814 sodium ion transport
GO:0009986 cell surface
GO:0010765 positive regulation of sodium ion transport
GO:0014704 intercalated disc
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0017134 fibroblast growth factor binding
GO:0019228 neuronal action potential
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0030506 ankyrin binding
GO:0031625 ubiquitin protein ligase binding
GO:0035725 sodium ion transmembrane transport
GO:0042383 sarcolemma
GO:0042475 odontogenesis of dentin-containing tooth
GO:0044325 transmembrane transporter binding
GO:0045760 positive regulation of action potential
GO:0048471 perinuclear region of cytoplasm
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050998 nitric-oxide synthase binding
GO:0051899 membrane depolarization
GO:0060048 cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061337 cardiac conduction
GO:0071277 cellular response to calcium ion
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086010 membrane depolarization during action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086014 atrial cardiac muscle cell action potential
GO:0086015 SA node cell action potential
GO:0086016 AV node cell action potential
GO:0086043 bundle of His cell action potential
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086060 voltage-gated sodium channel activity involved in AV node cell action potential
GO:0086061 voltage-gated sodium channel activity involved in bundle of His cell action potential
GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential
GO:0086063 voltage-gated sodium channel activity involved in SA node cell action potential
GO:0086067 AV node cell to bundle of His cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0097110 scaffold protein binding
GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential
GO:1902305 regulation of sodium ion transmembrane transport

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001696 Voltage gated sodium channel, alpha subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR008053 Voltage gated sodium channel, alpha-5 subunitFamilyFamily
IPR010526 Sodium ion transport-associatedDomainDomain
IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR043203 Voltage-gated cation channel calcium and sodiumFamilyFamily
IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gateDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00192 IndecainideDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00280 DisopyramideDrugbanksmall molecule
DB00281 LidocaineDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00379 MexiletineDrugbanksmall molecule
DB00473 HexylcaineDrugbanksmall molecule
DB00527 CinchocaineDrugbanksmall molecule
DB00532 MephenytoinDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00680 MoricizineDrugbanksmall molecule
DB00740 RiluzoleDrugbanksmall molecule
DB00750 PrilocaineDrugbanksmall molecule
DB00754 EthotoinDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00868 BenzonatateDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01056 TocainideDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01182 PropafenoneDrugbanksmall molecule
DB01195 FlecainideDrugbanksmall molecule
DB01228 EncainideDrugbanksmall molecule
DB01320 FosphenytoinDrugbanksmall molecule
DB01346 Quinidine barbiturateDrugbanksmall molecule
DB01426 AjmalineDrugbanksmall molecule
DB01429 AprindineDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB05541 BrivaracetamDrugbanksmall molecule
DB06217 VernakalantDrugbanksmall molecule
DB09085 TetracaineDrugbanksmall molecule
DB09088 AmylocaineDrugbanksmall molecule
DB09342 PropoxycaineDrugbanksmall molecule
DB09345 PramocaineDrugbanksmall molecule
DB11186 PentoxyverineDrugbanksmall molecule
DB11633 IsavuconazoleDrugbanksmall molecule
DB13269 Dichlorobenzyl alcoholDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
SCN5A_HUMANSNTG2_HUMANHPRD, MINT12429735 details
SCN5A_HUMANRGS2_HUMANHPRD, IntAct16169070 details
SCN5A_HUMANCALM2_HUMANBioGRID, DIP, I2D, UniProt11807557 15746172 16505387 21167176 22331908 22705208 25232683 details
SCN5A_HUMANPTN3_HUMANMINT16930557 details
SCN5A_HUMANANM1_HUMANMINT23912080 details
SCN5A_HUMANANM3_HUMANMINT23912080 details
SCN5A_HUMANANM5_HUMANMINT23912080 details
SCN5A_HUMANKCC2D_HUMANbhf-ucl22514276 details
SCN5A_HUMANDLG1_HUMANHPRD, MINT16637659 24550280 details
SCN5A_HUMANEMC9_HUMANBioGRID, IntAct32296183 details
SCN5A_HUMANBANP_HUMANBioGRID, IntAct32296183 details
SCN5A_HUMANTEKT4_HUMANBioGRID, IntAct32296183 details
SCN5A_HUMANZMY19_HUMANBioGRID, IntAct32296183 details
SCN5A_HUMANSNTA1_HUMANBioGRID, DIP, HPRD18591664 9412493 details
SCN5A_HUMANANK3_HUMANDIP19805355 details
SCN5A_HUMANFGF12_HUMANDIP22705208 details
SCN5A_HUMANNEDD4_HUMANBioGRID15217910 31614475 details
SCN5A_HUMANCALM1_HUMANBioGRID11807557 15746172 21167176 details
SCN5A_HUMANCALM3_HUMANBioGRID11807557 15746172 21167176 details
SCN5A_HUMANWWP2_HUMANBioGRID15548568 details
SCN5A_HUMANCDK2_HUMANBioGRID23421998 details
SCN5A_HUMANCRYAB_HUMANBioGRID26961874 details
SCN5A_HUMANNED4L_HUMANBioGRID, HPRD15217910 15548568 28296171 31900993 details
SCN5A_HUMANANS1A_HUMANBioGRID32296183 details
SCN5A_HUMANGPD1L_HUMANUniProt19666841 details
SCN5A_HUMANSNTB2_HUMANBioGRID, HPRD9412493 details
SCN5A_HUMANSNTB1_HUMANBioGRID, HPRD9412493 details
SCN5A_HUMANCAV3_HUMANBioGRID17060380 details
SCN5A_HUMANGAN_HUMANBioGRID26460568 details
SCN5A_HUMANCBL_HUMANHPRD8621719 details
SCN5A_HUMANDLG2_HUMANHPRD16637659 details
SCN5A_HUMANDLG4_HUMANHPRD16637659 details
SCN5A_HUMANSCN5A_HUMANHPRD16637659 details
SCN5A_HUMANDLG3_HUMANHPRD16637659 details
SCN5A_HUMANRGS3_HUMANHPRD16637659 details