Entity Details

Primary name I11RA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14626
EntryNameI11RA_HUMAN
FullNameInterleukin-11 receptor subunit alpha
TaxID9606
Evidenceevidence at protein level
Length422
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesIL11RA

GO terms

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GOName
GO:0004888 transmembrane signaling receptor activity
GO:0004896 cytokine receptor activity
GO:0004921 interleukin-11 receptor activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008284 positive regulation of cell population proliferation
GO:0009897 external side of plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0019970 interleukin-11 binding
GO:0032502 developmental process
GO:0043235 receptor complex
GO:0060322 head development

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR003530 Long hematopoietin receptor, soluble alpha chain, conserved siteSiteConserved site
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00038 OprelvekinDrugbankbiotech

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
I11RA_HUMANOLFM4_HUMANBioGRID, IntAct32296183 details
I11RA_HUMANIL11_HUMANIntAct26551460 details