Entity Details

Primary name HLA-DRA
Entity type gene
Source Source Link

Details

PrimaryID3122
RefseqGene
SymbolHLA-DRA
Namemajor histocompatibility complex, class II, DR alpha
Chromosome6
Location6p21.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1989-05-11
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsDRA_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001772 immunological synapse
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002469 myeloid dendritic cell antigen processing and presentation
GO:0002491 antigen processing and presentation of endogenous peptide antigen via MHC class II
GO:0002503 peptide antigen assembly with MHC class II protein complex
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016032 viral process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0023026 MHC class II protein complex binding
GO:0030247 polysaccharide binding
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032395 MHC class II receptor activity
GO:0032588 trans-Golgi network membrane
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042613 MHC class II protein complex
GO:0043382 positive regulation of memory T cell differentiation
GO:0045622 regulation of T-helper cell differentiation
GO:0050852 T cell receptor signaling pathway
GO:0050890 cognition
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0070062 extracellular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
HLA-DRAHLA-DRB1BioGRID, HPRD, InnateDB, IntAct, MINT11432818 11877480 21131964 26186194 28514442 7477400 9354468 details
HLA-DRAMARCHF1BioGRID23264739 details
HLA-DRATLR3BioGRID24600555 details
HLA-DRACD74HPRD, MINT16242130 details
HLA-DRAMBPBioGRID, HPRD, InnateDB21131964 9782128 details
HLA-DRAHLA-DRB5BioGRID, HPRD, IntAct12244309 26186194 28514442 details
HLA-DRAHLA-DMBBioGRID, HPRD, IntAct10716924 12932352 26186194 28514442 7648393 8574855 8920889 9371817 details
HLA-DRACD82BioGRID, HPRD9759843 details
HLA-DRACD63BioGRID, HPRD9759843 details
HLA-DRAMS4A1BioGRID20458337 22167754 details
HLA-DRATOLLIPBioGRID24600555 details
HLA-DRATMEM127BioGRID32526160 details
HLA-DRAPRPF40BHPRD9700202 details
HLA-DRADDX19BBioGRID, IntAct26186194 28514442 details
HLA-DRAKLK4BioGRID, IntAct26186194 28514442 details
HLA-DRAPOMT2BioGRID, IntAct26186194 28514442 details
HLA-DRALNPEPBioGRID, IntAct26186194 28514442 details
HLA-DRAEIF2AK3BioGRID, IntAct26186194 28514442 details
HLA-DRABPNT2BioGRID, IntAct26186194 28514442 details
HLA-DRACNTNAP3BioGRID, IntAct26186194 28514442 details
HLA-DRADCBLD2BioGRID, IntAct26186194 28514442 details
HLA-DRALRIG1BioGRID, IntAct26186194 28514442 details
HLA-DRATCTN2BioGRID, IntAct26186194 28514442 details
HLA-DRASCARB1BioGRID, IntAct26186194 28514442 details
HLA-DRANETO2BioGRID, IntAct26186194 28514442 details
HLA-DRAKCNIP4BioGRID, IntAct28514442 details
HLA-DRATMEM97BioGRID, IntAct26186194 28514442 details
HLA-DRAEPHB4BioGRID, IntAct26186194 28514442 details
HLA-DRAMAN2A2BioGRID, IntAct26186194 28514442 details
HLA-DRAEPHA3BioGRID, IntAct26186194 28514442 details
HLA-DRAPKMBioGRID20458337 details
HLA-DRAHSP90AA1BioGRID20458337 details
HLA-DRAHSPA8BioGRID20458337 details
HLA-DRAANXA11BioGRID20458337 details
HLA-DRAHSP90AB1BioGRID20458337 details
HLA-DRAATP1B1BioGRID20458337 details
HLA-DRAYWHAEBioGRID20458337 details
HLA-DRATMEM131LBioGRID26186194 details
HLA-DRAATP2B2BioGRID26186194 details
HLA-DRACELSR1BioGRID26186194 details
HLA-DRASTIM1BioGRID26186194 details
HLA-DRAPLXNA1BioGRID26186194 details
HLA-DRASLC25A16BioGRID26186194 details
HLA-DRACHST12BioGRID26186194 details
HLA-DRAPACC1BioGRID26186194 details
HLA-DRALRFN3BioGRID26186194 details
HLA-DRAPLEKHA2BioGRID19786618 details
HLA-DRABRWD3BioGRID31753913 details
HLA-DRARMC1BioGRID33144569 details
HLA-DRARFX5NTNU7744245 details