Entity Details

Primary name JAK3
Entity type gene
Source Source Link

Details

PrimaryID3718
RefseqGeneNG_007273
SymbolJAK3
NameJanus kinase 3
Chromosome19
Location19p13.11
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsJAK3_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002250 adaptive immune response
GO:0002731 negative regulation of dendritic cell cytokine production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005768 endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0030183 B cell differentiation
GO:0030218 erythrocyte differentiation
GO:0032693 negative regulation of interleukin-10 production
GO:0032695 negative regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0035723 interleukin-15-mediated signaling pathway
GO:0035771 interleukin-4-mediated signaling pathway
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038111 interleukin-7-mediated signaling pathway
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0045087 innate immune response
GO:0045221 negative regulation of FasL production
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0050868 negative regulation of T cell activation
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070232 regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071104 response to interleukin-9

Diseases

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Interactions

93 interactions

InteractorPartnerSourcesPublicationsLink
JAK3ERBB3BioGRID, MINT16273093 details
JAK3CDK1BioGRID, IntAct21988832 details
JAK3GTF2BBioGRID, IntAct21988832 details
JAK3CD81BioGRID, IntAct21988832 details
JAK3APOA1BioGRID, IntAct21988832 details
JAK3IKBKGBioGRID, IntAct20098747 details
JAK3UHRF2BioGRID, UniProt21952639 details
JAK3NFATC1InnateDB23263556 details
JAK3LNX1BioGRID, IntAct25814554 details
JAK3TIAF1BioGRID, HPRD10733938 details
JAK3STAT5ABioGRID, HPRD10037026 18250158 9047382 details
JAK3PRMT5BioGRID, HPRD10531356 details
JAK3SHBBioGRID, HPRD12200137 details
JAK3STAT5BBioGRID9047382 details
JAK3CD247BioGRID, HPRD11349123 details
JAK3JAK1BioGRID, HPRD12207328 12559972 32001089 9553136 details
JAK3KITBioGRID17554063 details
JAK3SOCS1BioGRID, HPRD11133764 27144517 29674694 29991678 details
JAK3KHDRBS1HPRD, IntAct9045636 details
JAK3ROCK2IntAct30413785 details
JAK3PTK2BBioGRID, HPRD9512511 details
JAK3CXCR4BioGRID, HPRD10506573 details
JAK3IL2RGBioGRID, HPRD27742835 7973658 7973659 details
JAK3ALKBioGRID, HPRD11850821 14968112 details
JAK3IRS1BioGRID, HPRD7499365 details
JAK3CD3EBioGRID11349123 details
JAK3STAMBioGRID, HPRD10899310 9133424 details
JAK3STAM2BioGRID, HPRD10899310 details
JAK3SOCS3BioGRID, HPRD10373548 15385932 details
JAK3IL4RBioGRID, HPRD12207328 7538655 details
JAK3JAK2BioGRID, HPRD11585385 12207328 details
JAK3TYK2BioGRID12207328 details
JAK3STAT3BioGRID, HPRD10037026 12207328 details
JAK3STAT6BioGRID12207328 details
JAK3IL7RBioGRID, HPRD15996891 17554063 7481769 details
JAK3IL2RBBioGRID, HPRD10825200 20816854 7973659 9553136 details
JAK3JAK3HPRD15121872 9391116 details
JAK3IRS2HPRD7499365 details
JAK3PTPN2HPRD11909529 15588985 details
JAK3SH2B2HPRD10872802 details
JAK3PIK3R1HPRD7662955 details
JAK3PTPN6HPRD9520455 details
JAK3FESHPRD11160325 details
JAK3INPP5DHPRD10875931 details
JAK3CD40HPRD10395671 9133417 details
JAK3VIL1HPRD17537734 details
JAK3PTPRCHPRD11994288 details
JAK3LCKHPRD11278738 details
JAK3LEPRBioGRID, IntAct11585385 details
JAK3PKMIntAct24606918 details
JAK3MAGED2BioGRID, IntAct25852190 details
JAK3NAP1L1BioGRID, IntAct25852190 details
JAK3NAP1L4BioGRID, IntAct25852190 details
JAK3TCP1BioGRID, IntAct25852190 26496610 details
JAK3CCT8BioGRID, IntAct25852190 26496610 details
JAK3GNASBioGRID, IntAct25852190 details
JAK3GPATCH8BioGRID, IntAct25852190 details
JAK3CCT4BioGRID, IntAct25852190 26496610 details
JAK3BAG2BioGRID, IntAct25852190 details
JAK3RNPS1BioGRID, IntAct25852190 details
JAK3CCT3BioGRID, IntAct25852190 details
JAK3CCT6ABioGRID, IntAct25852190 26496610 details
JAK3GEMIN6BioGRID, IntAct26496610 details
JAK3MTF2BioGRID, IntAct26496610 details
JAK3RAB11BIntAct26496610 details
JAK3MRPL23BioGRID, IntAct26496610 details
JAK3UBR5BioGRID, IntAct26496610 details
JAK3CAPN2BioGRID, IntAct26496610 details
JAK3RAB11FIP2BioGRID, IntAct26496610 details
JAK3CENPCBioGRID, IntAct26496610 details
JAK3SPTLC1BioGRID, IntAct26496610 details
JAK3LYSMD2BioGRID, IntAct26496610 details
JAK3TNPO3BioGRID, IntAct26496610 details
JAK3COX4I1BioGRID, IntAct26496610 details
JAK3DECR1BioGRID, IntAct26496610 details
JAK3STUB1BioGRID, IntAct26496610 details
JAK3ARAFBioGRID, IntAct26496610 details
JAK3INPP5BBioGRID, IntAct26496610 details
JAK3NMIBioGRID, IntAct26496610 details
JAK3TUBA4ABioGRID, IntAct26496610 details
JAK3CRY1BioGRID, IntAct26496610 details
JAK3CCNL2BioGRID, IntAct26496610 details
JAK3TPTEP2-CSNK1EIntAct26496610 details
JAK3CSNK1EBioGRID, IntAct26496610 details
JAK3DHX16BioGRID, IntAct26496610 details
JAK3CDK4BioGRID, IntAct26186194 28514442 details
JAK3CCT2BioGRID25852190 details
JAK3SRRM2BioGRID25852190 details
JAK3TUBB1BioGRID25852190 details
JAK3TAF1BioGRID26496610 details
JAK3RAB11ABioGRID26496610 details
JAK3WDR46BioGRID26496610 details
JAK3UBE2MBioGRID28581483 details