Entity Details

Primary name EPHA7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15375
EntryNameEPHA7_HUMAN
FullNameEphrin type-A receptor 7
TaxID9606
Evidenceevidence at protein level
Length998
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA7

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006915 apoptotic process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008046 axon guidance receptor activity
GO:0016310 phosphorylation
GO:0019838 growth factor binding
GO:0022407 regulation of cell-cell adhesion
GO:0030425 dendrite
GO:0031290 retinal ganglion cell axon guidance
GO:0031594 neuromuscular junction
GO:0031952 regulation of protein autophosphorylation
GO:0033674 positive regulation of kinase activity
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045499 chemorepellent activity
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0048671 negative regulation of collateral sprouting
GO:0048755 branching morphogenesis of a nerve
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050919 negative chemotaxis
GO:0051964 negative regulation of synapse assembly
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0072178 nephric duct morphogenesis
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:0099175 regulation of postsynapse organization

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034283 Ephrin type-A receptor 7, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07970 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamideDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule