Entity Details

Primary name MED1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15648
EntryNameMED1_HUMAN
FullNameMediator of RNA polymerase II transcription subunit 1
TaxID9606
Evidenceevidence at protein level
Length1581
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMED1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0000902 cell morphogenesis
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0002088 lens development in camera-type eye
GO:0002154 thyroid hormone mediated signaling pathway
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003406 retinal pigment epithelium development
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006590 thyroid hormone generation
GO:0006606 protein import into nucleus
GO:0006702 androgen biosynthetic process
GO:0007420 brain development
GO:0007595 lactation
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0010839 negative regulation of keratinocyte proliferation
GO:0016020 membrane
GO:0016592 mediator complex
GO:0016922 nuclear receptor binding
GO:0019216 regulation of lipid metabolic process
GO:0030216 keratinocyte differentiation
GO:0030224 monocyte differentiation
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0031100 animal organ regeneration
GO:0031490 chromatin DNA binding
GO:0032993 protein-DNA complex
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0035050 embryonic heart tube development
GO:0035116 embryonic hindlimb morphogenesis
GO:0035162 embryonic hemopoiesis
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035855 megakaryocyte development
GO:0042789 mRNA transcription by RNA polymerase II
GO:0042809 vitamin D receptor binding
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045444 fat cell differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046966 thyroid hormone receptor binding
GO:0048821 erythrocyte development
GO:0048822 enucleate erythrocyte development
GO:0050693 LBD domain binding
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744 mammary gland branching involved in thelarche
GO:0060745 mammary gland branching involved in pregnancy
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0061630 ubiquitin protein ligase activity
GO:0070318 positive regulation of G0 to G1 transition
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0097067 cellular response to thyroid hormone stimulus
GO:1990841 promoter-specific chromatin binding
GO:2000347 positive regulation of hepatocyte proliferation
GO:2001141 regulation of RNA biosynthetic process

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR019680 Mediator complex, subunit Med1DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04891 BecocalcidiolDrugbanksmall molecule

Interactions

97 interactions

InteractorPartnerSourcesPublicationsLink
MED1_HUMANMED29_HUMANBioGRID, IntAct14638676 15175163 15989967 20133760 22939629 24981860 26344197 28514442 details
MED1_HUMANP53_HUMANBioGRID, HPRD, MINT11118038 15848166 9444950 details
MED1_HUMANPPARG_HUMANBioGRID, HPRD, UniProt10037764 10935544 11027271 11500849 11877444 12037571 15026545 15604093 16554032 17011503 17468099 17704298 19596656 22070604 23178929 30575522 30595551 30651555 9325263 details
MED1_HUMANRARA_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10760302 17641689 21478865 25303530 9653119 details
MED1_HUMANESR2_HUMANBioGRID, HPRD, IntAct10770935 11500849 11867769 21182203 details
MED1_HUMANCXB5_HUMANBioGRID, IntAct21988832 details
MED1_HUMANTHA_HUMANBioGRID, HPRD, UniProt10037764 10733574 11117530 16799563 18391015 21868449 8710870 9653119 details
MED1_HUMANVDR_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10198638 10235266 10733574 10753860 12403843 12796488 15919092 16434701 17786964 21478865 9653119 details
MED1_HUMANRXRA_HUMANBioGRID, DIP, HPRD, UniProt10935544 11027271 11438648 15863722 21478865 9653119 details
MED1_HUMANESR1_HUMANBioGRID, HPRD, IntAct, UniProt10760302 10770935 11867769 12738788 15886699 18391015 31527615 9653119 details
MED1_HUMANMYC_HUMANBioGRID, IntAct17967894 25303530 details
MED1_HUMANNR1H3_HUMANIntAct26120082 details
MED1_HUMANNR1H2_HUMANBioGRID, HPRD, IntAct15604093 26120082 details
MED1_HUMANMED18_HUMANBioGRID, IntAct, MINT15989967 20133760 22939629 24981860 26344197 28514442 details
MED1_HUMANMED28_HUMANBioGRID, IntAct15175163 15989967 20133760 24981860 28514442 details
MED1_HUMANNR1I3_HUMANBioGRID, HPRD, IntAct15572376 26186194 28514442 details
MED1_HUMANSRBP1_HUMANBioGRID, DIP10235267 16799563 details
MED1_HUMANGATA1_HUMANBioGRID, DIP, HPRD11724781 17132730 details
MED1_HUMANPRGC1_HUMANBioGRID, HPRD14636573 details
MED1_HUMANGCR_HUMANBioGRID10508170 11266503 28611094 31182584 details
MED1_HUMAN1433T_HUMANBioGRID11266503 details
MED1_HUMANTGS1_HUMANBioGRID11912212 details
MED1_HUMANMED1_HUMANBioGRID, HPRD12037571 12562779 15989967 20133760 23322298 9444950 details
MED1_HUMANHNF4A_HUMANBioGRID, HPRD12089346 12101254 details
MED1_HUMANANDR_HUMANBioGRID, HPRD12218053 details
MED1_HUMANGABPA_HUMANBioGRID16574658 details
MED1_HUMANPIT1_HUMANBioGRID16396960 details
MED1_HUMANGATA2_HUMANBioGRID16396960 details
MED1_HUMANKIF1A_HUMANBioGRID15604093 details
MED1_HUMANCTDP1_HUMANBioGRID16239144 details
MED1_HUMANNCOA6_HUMANBioGRID21292004 details
MED1_HUMANEZH2_HUMANBioGRID17502350 details
MED1_HUMANPIN1_HUMANBioGRID16055720 details
MED1_HUMANAKAP9_HUMANBioGRID30217970 details
MED1_HUMANCSKP_HUMANBioGRID30217970 details
MED1_HUMANRBM5_HUMANBioGRID30217970 details
MED1_HUMANRFA2_HUMANBioGRID30217970 details
MED1_HUMANTET2_HUMANBioGRID30404004 details
MED1_HUMANMK03_HUMANBioGRID18391015 details
MED1_HUMANRORA_HUMANHPRD10478845 details
MED1_HUMANMED19_HUMANBioGRID, IntAct14576168 14638676 15175163 15989967 20133760 21729782 24981860 26186194 26344197 28514442 details
MED1_HUMANMED10_HUMANBioGRID, IntAct10882111 14576168 14638676 15175163 15989967 24882805 24981860 28514442 details
MED1_HUMANMED9_HUMANBioGRID, HPRD, IntAct14638676 15175163 20098423 24882805 24981860 27684187 28514442 details
MED1_HUMANCDK19_HUMANBioGRID, IntAct15175163 20133760 22939629 23602568 24981860 26186194 28514442 details
MED1_HUMANMDM2_HUMANBioGRID, HPRD, MINT15848166 details
MED1_HUMANKAT2A_HUMANBioGRID, MINT17967894 18418385 20508642 details
MED1_HUMANCDK8_HUMANBioGRID, DIP, IntAct, MINT10024883 10198638 10882111 11867769 15989967 18418385 20098423 23322298 23602568 24981860 26186194 26496610 28514442 29568061 details
MED1_HUMANMED24_HUMANBioGRID, DIP, IntAct, UniProt15989967 18391015 20098423 20133760 22939629 24981860 26344197 28514442 9653119 details
MED1_HUMANPPARA_HUMANUniProt9653119 details
MED1_HUMANMED21_HUMANBioGRID, IntAct, MINT15989967 22939629 24882805 24981860 28514442 details
MED1_HUMANMED7_HUMANBioGRID, IntAct, MINT15989967 18391015 24882805 24981860 26186194 28514442 details
MED1_HUMANMED4_HUMANBioGRID, IntAct, MINT15989967 20133760 22939629 24882805 24981860 25281560 26344197 28514442 details
MED1_HUMANMED12_HUMANBioGRID, DIP, HPRD, IntAct15175163 15989967 20098423 20133760 23322298 23563140 24981860 26344197 26496610 27684187 28514442 details
MED1_HUMANRPAB2_HUMANBioGRID, IntAct15989967 24981860 26496610 details
MED1_HUMANPLK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
MED1_HUMANSPAG5_HUMANBioGRID, IntAct27173435 unassigned1312 details
MED1_HUMANMED31_HUMANBioGRID, IntAct, MINT15989967 24981860 28514442 details
MED1_HUMANMED16_HUMANBioGRID, DIP, IntAct15989967 17967894 20098423 20133760 22939629 24981860 26344197 28514442 details
MED1_HUMANMED23_HUMANBioGRID, DIP, IntAct, MINT15989967 20098423 20133760 25281560 28514442 details
MED1_HUMANMED13_HUMANBioGRID, DIP, IntAct15989967 20098423 20133760 23322298 23563140 24981860 26344197 28514442 29568061 details
MED1_HUMANMED11_HUMANBioGRID, IntAct15989967 22939629 24981860 28514442 details
MED1_HUMANMED17_HUMANBioGRID, DIP, IntAct15989967 17967894 18391015 20098423 20133760 24981860 26344197 28514442 details
MED1_HUMANMED20_HUMANBioGRID, IntAct, MINT15989967 20133760 24981860 25281560 26344197 28514442 details
MED1_HUMANMED15_HUMANBioGRID, DIP, IntAct14657022 15989967 20098423 20133760 24981860 26344197 28514442 details
MED1_HUMANMED30_HUMANBioGRID, IntAct, MINT15989967 18691967 20133760 24981860 28514442 details
MED1_HUMANMED8_HUMANBioGRID, HPRD, IntAct12584197 15989967 20133760 22939629 24981860 26344197 28514442 details
MED1_HUMANMD13L_HUMANBioGRID, IntAct23322298 24981860 28514442 details
MED1_HUMANMED27_HUMANBioGRID, IntAct15989967 20133760 22939629 24981860 26344197 28514442 details
MED1_HUMANMED22_HUMANBioGRID, IntAct15989967 20098423 20133760 24981860 28514442 details
MED1_HUMANRPB1_HUMANBioGRID, IntAct15989967 24981860 28514442 details
MED1_HUMANMED6_HUMANBioGRID, IntAct15989967 18391015 20133760 22939629 24981860 26344197 28514442 details
MED1_HUMANMED14_HUMANBioGRID, DIP, HPRD, IntAct15175163 15989967 20098423 20133760 22939629 24981860 26344197 28514442 9989412 details
MED1_HUMANCCNC_HUMANBioGRID, DIP18391015 20098423 20133760 24981860 26186194 28514442 details
MED1_HUMANBRD4_HUMANBioGRID, DIP19766566 20098423 31239290 32416067 details
MED1_HUMANMED25_HUMANBioGRID, DIP, HPRD, IntAct14657022 14983011 15989967 17641689 20098423 20133760 25792360 28514442 details
MED1_HUMANRPAB1_HUMANBioGRID, MINT20133760 24981860 details
MED1_HUMANATM_HUMANBioGRID17478428 details
MED1_HUMANPARP1_HUMANBioGRID16204234 details
MED1_HUMANSUPT3_HUMANBioGRID17967894 details
MED1_HUMANST65G_HUMANBioGRID17967894 details
MED1_HUMANCDK9_HUMANBioGRID20133760 details
MED1_HUMANZC3HD_HUMANBioGRID20133760 details
MED1_HUMANTRIP4_HUMANBioGRID20133760 details
MED1_HUMANSTN1_HUMANBioGRID20133760 details
MED1_HUMANQKI_HUMANBioGRID20133760 details
MED1_HUMANFBXW7_HUMANBioGRID23322298 25720964 details
MED1_HUMANAHR_HUMANBioGRID17392787 details
MED1_HUMANTBP_HUMANBioGRID18391015 details
MED1_HUMANTF2B_HUMANBioGRID18391015 details
MED1_HUMANT2FB_HUMANBioGRID18391015 details
MED1_HUMAN1433F_HUMANHPRD11266503 details
MED1_HUMANTHB_HUMANHPRD9325263 details
MED1_HUMANGATA4_HUMANHPRD11724781 details
MED1_HUMANGATA6_HUMANHPRD11724781 details
MED1_HUMANBRCA1_HUMANHPRD15208681 details
MED1_HUMANGATA3_HUMANHPRD11724781 details
MED1_HUMANNR4A1_HUMANHPRD12082103 details