Entity Details

Primary name LRP5
Entity type gene
Source Source Link

Details

PrimaryID4041
RefseqGeneNG_015835
SymbolLRP5
NameLDL receptor related protein 5
Chromosome11
Location11q13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-05-04
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsLRP5_HUMAN

GO terms

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GOName
GO:0001702 gastrulation with mouth forming second
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002076 osteoblast development
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006007 glucose catabolic process
GO:0006897 endocytosis
GO:0008203 cholesterol metabolic process
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009952 anterior/posterior pattern specification
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0017147 Wnt-protein binding
GO:0033690 positive regulation of osteoblast proliferation
GO:0035019 somatic stem cell population maintenance
GO:0035426 extracellular matrix-cell signaling
GO:0042074 cell migration involved in gastrulation
GO:0042632 cholesterol homeostasis
GO:0042733 embryonic digit morphogenesis
GO:0042813 Wnt-activated receptor activity
GO:0042981 regulation of apoptotic process
GO:0043235 receptor complex
GO:0043434 response to peptide hormone
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046849 bone remodeling
GO:0048539 bone marrow development
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060033 anatomical structure regression
GO:0060042 retina morphogenesis in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060349 bone morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060612 adipose tissue development
GO:0060764 cell-cell signaling involved in mammary gland development
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061304 retinal blood vessel morphogenesis
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071936 coreceptor activity involved in Wnt signaling pathway
GO:0110135 Norrin signaling pathway
GO:1901998 toxin transport
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway
GO:1990851 Wnt-Frizzled-LRP5/6 complex
GO:1990909 Wnt signalosome

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
LRP5SMAD9BioGRID, HPRD, MINT15231748 details
LRP5CAPRIN2bhf-ucl, BioGRID18762581 details
LRP5FZD8BioGRID, HPRD11448771 details
LRP5SOSTbhf-ucl, BioGRID, IntAct, UniProt15908424 21471202 28514442 details
LRP5DKK1BioGRID, HPRD, IntAct11516963 15035989 26186194 28514442 details
LRP5APCDD1DIP20393562 details
LRP5AXIN1BioGRID, HPRD11336703 18632848 18762581 details
LRP5LRP6BioGRID28966723 details
LRP5TRAF6BioGRID31262711 details
LRP5CTNNB1BioGRID31262711 details
LRP5THBS1HPRD7775583 details
LRP5MESDHPRD12581525 details
LRP5WNT1HPRD11336703 details
LRP5NDPIntAct19837033 details
LRP5JUNMINT25609649 details
LRP5MGAT4CBioGRID, IntAct28514442 details
LRP5POMKBioGRID, IntAct26186194 28514442 details
LRP5SCGB1D1BioGRID, IntAct28514442 details
LRP5PARP16BioGRID, IntAct26186194 28514442 details
LRP5DKKL1BioGRID, IntAct28514442 details
LRP5CSNK1A1BioGRID, IntAct28514442 details
LRP5TGIF2LYBioGRID, IntAct28514442 details
LRP5ODAPHBioGRID, IntAct28514442 details
LRP5SUSD4BioGRID, IntAct26186194 28514442 details
LRP5F9BioGRID, IntAct28514442 details
LRP5RASD2BioGRID, IntAct26186194 28514442 details
LRP5TAFAZZINBioGRID, IntAct26186194 28514442 details
LRP5ST8SIA4BioGRID, IntAct28514442 details
LRP5LRRC4CBioGRID, IntAct28514442 details
LRP5FCGRTBioGRID, IntAct28514442 details
LRP5PRSS37BioGRID, IntAct28514442 details
LRP5SERPINA12BioGRID, IntAct28514442 details
LRP5BRINP3BioGRID, IntAct28514442 details
LRP5NXPH2BioGRID, IntAct28514442 details
LRP5CLPSL1BioGRID, IntAct28514442 details
LRP5B3GALT2BioGRID, IntAct26186194 28514442 details
LRP5CHST9BioGRID, IntAct26186194 28514442 details
LRP5FAM3BBioGRID, IntAct28514442 details
LRP5ETV6BioGRID, IntAct26186194 28514442 details
LRP5PODNBioGRID, IntAct28514442 details
LRP5LIPHBioGRID, IntAct26186194 28514442 details
LRP5ADAM33BioGRID, IntAct28514442 details
LRP5DKK4BioGRID, IntAct28514442 details
LRP5B3GAT1BioGRID34079125 details
LRP5ELOVL5BioGRID34079125 details
LRP5TRIM25BioGRID29117863 details
LRP5HNRNPLBioGRID28611215 details
LRP5TNIP2BioGRID27609421 details
LRP5VIRMABioGRID29507755 details
LRP5MTDHBioGRID22199357 details