Entity Details

Primary name MTHFD1
Entity type gene
Source Source Link

Details

PrimaryID4522
RefseqGeneNG_012450
SymbolMTHFD1
Namemethylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Chromosome14
Location14q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-07-23
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsC1TC_HUMAN

GO terms

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GOName
GO:0000105 histidine biosynthetic process
GO:0001843 neural tube closure
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004486 methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006164 purine nucleotide biosynthetic process
GO:0006555 methionine metabolic process
GO:0006730 one-carbon metabolic process
GO:0007507 heart development
GO:0009069 serine family amino acid metabolic process
GO:0009070 serine family amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009257 10-formyltetrahydrofolate biosynthetic process
GO:0016020 membrane
GO:0035999 tetrahydrofolate interconversion
GO:0046655 folic acid metabolic process
GO:0048702 embryonic neurocranium morphogenesis
GO:0048703 embryonic viscerocranium morphogenesis
GO:0061053 somite development
GO:0070062 extracellular exosome

Diseases

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Interactions

159 interactions

InteractorPartnerSourcesPublicationsLink
MTHFD1DUX4BioGRID, IntAct26816005 details
MTHFD1ESR1BioGRID, IntAct20348541 31527615 details
MTHFD1SUMO2BioGRID32786267 details
MTHFD1CCNA1IntAct17353931 details
MTHFD1TNFRSF10DIntAct17353931 details
MTHFD1ARF6IntAct17353931 details
MTHFD1TNIKIntAct17353931 details
MTHFD1CDK2BioGRID, IntAct17353931 21319273 details
MTHFD1GH1IntAct17353931 details
MTHFD1HLA-BIntAct17353931 details
MTHFD1HDAC5BioGRID21081666 details
MTHFD1HSP90AA1BioGRID16263121 details
MTHFD1GANBioGRID26460568 details
MTHFD1U2AF2BioGRID26641092 details
MTHFD1PRMT8BioGRID18320585 details
MTHFD1PREX1BioGRID26792863 details
MTHFD1ISG15BioGRID33024031 details
MTHFD1MTHFD1HPRD10828945 9519408 details
MTHFD1HSP90AB1BioGRID, MINT16263121 details
MTHFD1WRAP73BioGRID, IntAct17353931 details
MTHFD1MCCBioGRID, IntAct17353931 details
MTHFD1TRAF6BioGRID, IntAct17353931 details
MTHFD1MMEBioGRID, IntAct17342744 details
MTHFD1MAP1LC3AIntAct20562859 details
MTHFD1GABARAPL1IntAct20562859 details
MTHFD1GABARAPIntAct20562859 details
MTHFD1RNF169MINT21252943 details
MTHFD1VCAM1BioGRID, IntAct19738201 22623428 details
MTHFD1DCUN1D1BioGRID, IntAct21145461 details
MTHFD1CUL2BioGRID, IntAct21145461 details
MTHFD1CUL3BioGRID, IntAct21145461 details
MTHFD1STK4IntAct23386615 details
MTHFD1OTUB1IntAct26752685 details
MTHFD1NFKB1MINT25609649 details
MTHFD1JUNMINT25609649 details
MTHFD1CA10BioGRID, IntAct26186194 28514442 details
MTHFD1KDM1ADIP26751641 details
MTHFD1ANGMINT28777577 details
MTHFD1NBEAL2IntAct29187380 details
MTHFD1DLDBioGRID, IntAct29128334 details
MTHFD1DNM1LBioGRID, IntAct29128334 details
MTHFD1PARK7BioGRID, IntAct29128334 details
MTHFD1SOD1BioGRID, IntAct29128334 details
MTHFD1MAPTBioGRID, UniProt26269332 details
MTHFD1DNAJC17BioGRID, IntAct30021884 details
MTHFD1AHNAKBioGRID, IntAct30021884 details
MTHFD1IQCHBioGRID, IntAct30021884 details
MTHFD1LRRK2IntAct31046837 details
MTHFD1PRKNBioGRID, UniProt25959826 32929329 details
MTHFD1CFTRBioGRID, IntAct26618866 29924966 details
MTHFD1CAV1BioGRID, IntAct31980649 details
MTHFD1CNR2MINT31616248 details
MTHFD1UBCBioGRID16196087 details
MTHFD1PSMA3BioGRID22079093 details
MTHFD1FBXO25BioGRID20473970 details
MTHFD1IARS2BioGRID22939629 details
MTHFD1ALDH18A1BioGRID22939629 24981860 details
MTHFD1SARS2BioGRID22939629 details
MTHFD1CAVIN3BioGRID22939629 details
MTHFD1PPT2BioGRID22939629 details
MTHFD1MRPL58BioGRID22939629 details
MTHFD1PCBioGRID22939629 details
MTHFD1SNRNP70BioGRID22939629 details
MTHFD1CDH2BioGRID22939629 details
MTHFD1MRPL49BioGRID22939629 details
MTHFD1PRPHBioGRID22939629 details
MTHFD1TMEM165BioGRID22939629 details
MTHFD1FAF2BioGRID22939629 details
MTHFD1MRPL23BioGRID22939629 details
MTHFD1SFXN1BioGRID22939629 details
MTHFD1RPL32BioGRID22939629 details
MTHFD1GAABioGRID22939629 details
MTHFD1DBN1BioGRID22939629 details
MTHFD1SF3B3BioGRID22939629 details
MTHFD1ACSL3BioGRID22939629 details
MTHFD1CD81BioGRID23463506 details
MTHFD1ADRB2BioGRID23798571 details
MTHFD1FBXO6BioGRID22268729 details
MTHFD1MAT2ABioGRID22863883 details
MTHFD1RPS21BioGRID22863883 details
MTHFD1UBQLN1BioGRID22863883 details
MTHFD1RPA1BioGRID24332808 details
MTHFD1RPA2BioGRID24332808 details
MTHFD1RPA3BioGRID24332808 details
MTHFD1FUSBioGRID25192599 details
MTHFD1CUL7BioGRID24711643 details
MTHFD1CCDC8BioGRID24711643 details
MTHFD1RNF2BioGRID24457600 details
MTHFD1ABCF2BioGRID26344197 details
MTHFD1CNN1BioGRID26344197 details
MTHFD1EIF3GBioGRID26344197 details
MTHFD1NLE1BioGRID26344197 details
MTHFD1PFKPBioGRID26344197 details
MTHFD1PHGDHBioGRID26344197 details
MTHFD1RPLP0BioGRID26344197 details
MTHFD1PAPOLABioGRID26344197 details
MTHFD1PFKLBioGRID26344197 details
MTHFD1PRPF19BioGRID26344197 details
MTHFD1RPL35ABioGRID26344197 details
MTHFD1RPL7BioGRID26344197 details
MTHFD1SAR1ABioGRID26344197 details
MTHFD1UBA1BioGRID26344197 details
MTHFD1XPNPEP1BioGRID26344197 details
MTHFD1NTRK1BioGRID25921289 details
MTHFD1CRY1BioGRID25756610 details
MTHFD1CRY2BioGRID25756610 details
MTHFD1MCM2BioGRID25963833 details
MTHFD1MEX3CBioGRID26471122 details
MTHFD1CDC73BioGRID27462432 details
MTHFD1ZNF746BioGRID25315684 details
MTHFD1SLC7A6OSBioGRID28561026 details
MTHFD1G3BP1BioGRID26777405 details
MTHFD1BRCA1BioGRID26831064 details
MTHFD1FBXO7BioGRID27503909 details
MTHFD1EGLN3BioGRID26972000 details
MTHFD1HSPA8BioGRID27684187 details
MTHFD1CTNNB1BioGRID27684187 details
MTHFD1PRPF8BioGRID28515276 details
MTHFD1EFTUD2BioGRID28515276 details
MTHFD1AAR2BioGRID28515276 details
MTHFD1PIH1D1BioGRID28515276 details
MTHFD1TNIP2BioGRID27609421 details
MTHFD1CDC34BioGRID29564676 details
MTHFD1SPDL1BioGRID30258100 details
MTHFD1ESR2BioGRID29509190 details
MTHFD1HEXIM1BioGRID29845934 details
MTHFD1RNF123BioGRID29676528 details
MTHFD1SNAI1BioGRID29331416 details
MTHFD1AGR2BioGRID30575818 details
MTHFD1RECQL4BioGRID29229926 details
MTHFD1TXNIPBioGRID29378950 details
MTHFD1MYCBioGRID29467282 details
MTHFD1ACTC1BioGRID30890647 details
MTHFD1PHBBioGRID27025967 details
MTHFD1USP14BioGRID30425250 details
MTHFD1NR2C2BioGRID30463901 details
MTHFD1UBQLN2BioGRID30442662 details
MTHFD1AGRNBioGRID29872149 details
MTHFD1HTRA2BioGRID31536960 details
MTHFD1POLDIP2BioGRID31536960 details
MTHFD1ITFG1BioGRID25437307 details
MTHFD1GSK3BBioGRID30711629 details
MTHFD1CYLDBioGRID31067453 details
MTHFD1BIRC3BioGRID30948266 details
MTHFD1NFX1BioGRID31059266 details
MTHFD1WWP2BioGRID31048545 details
MTHFD1BRD7BioGRID30940648 details
MTHFD1PLEKHA4BioGRID31091453 details
MTHFD1PINK1BioGRID31300519 details
MTHFD1SNIP1BioGRID30404004 details
MTHFD1MAP1LC3BBioGRID31006538 details
MTHFD1BRD4BioGRID31239290 details
MTHFD1PTENBioGRID32249768 details
MTHFD1RBM39BioGRID28302793 details
MTHFD1CD274BioGRID32941674 details
MTHFD1UFL1BioGRID32807901 details
MTHFD1TP53BioGRID32807901 details
MTHFD1TRIM25BioGRID29117863 details
MTHFD1VIRMABioGRID29507755 details