Entity Details

Primary name ATF4
Entity type gene
Source Source Link

Details

PrimaryID468
RefseqGene
SymbolATF4
Nameactivating transcription factor 4
Chromosome22
Location22q13.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-29
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsATF4_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0006094 gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006874 cellular calcium ion homeostasis
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0008022 protein C-terminus binding
GO:0008140 cAMP response element binding protein binding
GO:0009636 response to toxic substance
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010999 regulation of eIF2 alpha phosphorylation by heme
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0030182 neuron differentiation
GO:0030282 bone mineralization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031667 response to nutrient levels
GO:0032057 negative regulation of translational initiation in response to stress
GO:0032590 dendrite membrane
GO:0032922 circadian regulation of gene expression
GO:0032991 protein-containing complex
GO:0034198 cellular response to amino acid starvation
GO:0034399 nuclear periphery
GO:0034599 cellular response to oxidative stress
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0035162 embryonic hemopoiesis
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042789 mRNA transcription by RNA polymerase II
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043267 negative regulation of potassium ion transport
GO:0043522 leucine zipper domain binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045667 regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048167 regulation of synaptic plasticity
GO:0061395 positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070169 positive regulation of biomineral tissue development
GO:0070309 lens fiber cell morphogenesis
GO:0070982 L-asparagine metabolic process
GO:0090650 cellular response to oxygen-glucose deprivation
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0140467 integrated stress response signaling
GO:0140468 HRI-mediated signaling
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903351 cellular response to dopamine
GO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process
GO:1990037 Lewy body core
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990589 ATF4-CREB1 transcription factor complex
GO:1990590 ATF1-ATF4 transcription factor complex
GO:1990617 CHOP-ATF4 complex
GO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000120 positive regulation of sodium-dependent phosphate transport

Diseases

Show/Hide Table

Interactions

96 interactions

InteractorPartnerSourcesPublicationsLink
ATF4POLR2CBioGRID, HPRD, MINT12860379 details
ATF4TRIB3BioGRID, HPRD, IntAct12743605 18276110 20211142 25416956 25910212 32296183 details
ATF4CCDC106BioGRID, HPRD, IntAct16169070 25416956 29892012 31515488 32296183 details
ATF4GPS2BioGRID, HPRD, IntAct16189514 25416956 29892012 32296183 details
ATF4LDOC1BioGRID, HPRD, IntAct16189514 25416956 29892012 31515488 details
ATF4HAUS7BioGRID, HPRD, IntAct16189514 19447967 details
ATF4PTCD3BioGRID, HPRD, IntAct16189514 details
ATF4TTRBioGRID, HPRD, IntAct16189514 29892012 31515488 details
ATF4CREBZFBioGRID, HPIDb, MINT, UniProt16343488 20102225 23661758 details
ATF4ATF4BioGRID, MINT, UniProt16343488 23661758 details
ATF4DISC1BioGRID, HPRD, IntAct12812986 31413325 details
ATF4ZNF212BioGRID, IntAct18255255 details
ATF4NFKBIABioGRID, IntAct18255255 details
ATF4JUNBioGRID, HPRD, IntAct, UniProt1827203 20936779 23661758 25241761 details
ATF4HK3BioGRID, IntAct21988832 details
ATF4LMNB1BioGRID, IntAct21988832 details
ATF4MAP2K7BioGRID, IntAct21988832 details
ATF4BTRCBioGRID, IntAct11238952 16219772 18052253 19053519 21516116 21988832 25416956 26091241 26871637 29892012 31515488 32296183 details
ATF4MPZL2BioGRID, IntAct21988832 details
ATF4APH1ABioGRID, IntAct21988832 details
ATF4ASB7BioGRID, IntAct21988832 details
ATF4JUNBBioGRID, IntAct, UniProt21988832 23661758 details
ATF4MDM2BioGRID, IntAct21988832 27264869 details
ATF4RPS6BioGRID, IntAct21988832 details
ATF4SNAP29BioGRID, IntAct21988832 26359495 details
ATF4TGM2BioGRID, IntAct21988832 details
ATF4CKAP4BioGRID, IntAct21988832 details
ATF4REPS1BioGRID, IntAct21988832 details
ATF4FOSBioGRID, HPIDb, IntAct, UniProt20102225 23661758 25241761 details
ATF4CREBBPBioGRID, IntAct10350644 11564156 25241761 9295363 details
ATF4NDC80BioGRID, IntAct25416956 29892012 31515488 32296183 details
ATF4CEBPGBioGRID, HPIDb, HPRD, IntAct, UniProt1371974 20102225 20211142 23661758 25416956 32296183 details
ATF4BFSP2BioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
ATF4GOLGA1BioGRID, IntAct25416956 32296183 details
ATF4GCC1BioGRID, IntAct25416956 32296183 details
ATF4ATF3BioGRID, DIP, HPIDb, UniProt19164757 20102225 23661758 details
ATF4CEBPABioGRID, HPIDb, UniProt20102225 23661758 details
ATF4CEBPBHPIDb, HPRD11018027 20102225 details
ATF4CEBPDHPIDb20102225 details
ATF4DDIT3BioGRID, DIP, HPIDb, HPRD, UniProt12805554 18330356 20102225 23661758 details
ATF4BATFBioGRID, HPIDb, UniProt20102225 23661758 details
ATF4MAFBioGRID, HPIDb, UniProt20102225 23661758 details
ATF4NFE2L1HPIDb, HPRD11025215 20102225 details
ATF4NFE2L3HPIDb20102225 details
ATF4TARS3BioGRID, IntAct32296183 details
ATF4NAP1L5BioGRID, IntAct32296183 details
ATF4SAPCD2BioGRID, IntAct32296183 details
ATF4EXOC1IntAct32296183 details
ATF4CEP83BioGRID, IntAct32296183 details
ATF4AP1M1BioGRID, IntAct32296183 details
ATF4JDP2BioGRID, IntAct32296183 details
ATF4NLGN3BioGRID, IntAct25464930 details
ATF4NFE2L2BioGRID, HPRD, IntAct, UniProt11274184 23661758 26700459 32911434 details
ATF4CASP6IntAct32814053 details
ATF4LAMP2IntAct32814053 details
ATF4SH3GLB1IntAct32814053 details
ATF4PRPF40AIntAct32814053 details
ATF4CEBPEBioGRID, UniProt17042743 23661758 details
ATF4ATF2BioGRID, UniProt23661758 details
ATF4FOSL1BioGRID, UniProt23661758 details
ATF4CREB3BioGRID, UniProt23661758 details
ATF4BATF2BioGRID, UniProt23661758 details
ATF4BATF3BioGRID, UniProt23661758 details
ATF4MAFBBioGRID, UniProt23661758 details
ATF4NFE2BioGRID, UniProt23661758 details
ATF4GTF2A1LBioGRID, IntAct20211142 details
ATF4ZNF226BioGRID, IntAct20211142 details
ATF4TRIM24BioGRID, IntAct20211142 details
ATF4TREX2BioGRID16189514 details
ATF4TBPBioGRID9295363 details
ATF4GTF2F2BioGRID, HPRD9295363 details
ATF4GTF2BBioGRID9295363 details
ATF4GABBR1BioGRID11087824 details
ATF4GABBR2BioGRID, HPRD11087824 details
ATF4EP300BioGRID10350644 12471036 14630807 16219772 17872950 details
ATF4KAT2BBioGRID17726049 details
ATF4FBXW11BioGRID20724472 22017875 25332235 25515538 details
ATF4EGLN3BioGRID17684156 21951999 details
ATF4APPBioGRID21832049 details
ATF4SRA1BioGRID20398657 details
ATF4NEK6BioGRID20873783 details
ATF4DNMT3LBioGRID24952347 details
ATF4EGLN2BioGRID21951999 details
ATF4DAPK3HPRD, UniProt21408167 9488481 details
ATF4DAPK2UniProt21408167 details
ATF4EIF2ABioGRID15475356 details
ATF4ABRAXAS2BioGRID30854784 details
ATF4TBC1D25BioGRID, IntAct28514442 details
ATF4KTN1BioGRID, IntAct30021884 details
ATF4RNF4BioGRID29180619 details
ATF4STAT3IntAct25096061 details
ATF4HYOU1IntAct26700459 details
ATF4APOEIntAct22028770 details
ATF4SHMT2BioGRID22658674 details
ATF4MOV10BioGRID22658674 details
ATF4NXF1BioGRID22658674 details