Entity Details

Primary name SOST
Entity type gene
Source Source Link

Details

PrimaryID50964
RefseqGeneNG_008078
SymbolSOST
Namesclerostin
Chromosome17
Location17q21.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-15
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSOST_HUMAN

GO terms

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GOName
GO:0001503 ossification
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0008134 transcription factor binding
GO:0008201 heparin binding
GO:0009612 response to mechanical stimulus
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030279 negative regulation of ossification
GO:0030514 negative regulation of BMP signaling pathway
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032991 protein-containing complex
GO:0036122 BMP binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway

Diseases

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Interactions

25 interactions

InteractorPartnerSourcesPublicationsLink
SOSTLRP6bhf-ucl, BioGRID, DIP, IntAct, UniProt15908424 21471202 21944579 28514442 details
SOSTLRP4BioGRID, IntAct, UniProt21471202 28514442 details
SOSTPLEKHF2BioGRID, IntAct32296183 details
SOSTLRP5bhf-ucl, BioGRID, IntAct, UniProt15908424 21471202 28514442 details
SOSTKCTD10BioGRID, IntAct28514442 details
SOSTSRRTBioGRID, IntAct28514442 details
SOSTPSMG3BioGRID, IntAct28514442 details
SOSTPRMT6BioGRID, IntAct28514442 details
SOSTDCAF5BioGRID, IntAct28514442 details
SOSTAHCYL2BioGRID, IntAct28514442 details
SOSTSIRT1BioGRID, IntAct28514442 details
SOSTPSMG2BioGRID, IntAct28514442 details
SOSTSORL1BioGRID, IntAct28514442 details
SOSTLRP2BioGRID, IntAct28514442 details
SOSTGTF2IBioGRID, IntAct28514442 details
SOSTGLDCBioGRID, IntAct28514442 details
SOSTIMPDH1BioGRID, IntAct28514442 details
SOSTCSH1IntAct28514442 details
SOSTCSH2BioGRID, IntAct28514442 details
SOSTAP2A1BioGRID, IntAct28514442 details
SOSTHERC2BioGRID, IntAct28514442 details
SOSTPMPCBBioGRID, IntAct28514442 details
SOSTSPOPBioGRID, IntAct28514442 details
SOSTKPNA4BioGRID, IntAct28514442 details
SOSTHLA-DPB1BioGRID, IntAct28514442 details