Entity Details

Primary name PSEN2
Entity type gene
Source Source Link

Details

PrimaryID5664
RefseqGeneNG_007381
SymbolPSEN2
Namepresenilin 2
Chromosome1
Location1q42.13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPSN2_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000776 kinetochore
GO:0004175 endopeptidase activity
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005938 cell cortex
GO:0006509 membrane protein ectodomain proteolysis
GO:0006816 calcium ion transport
GO:0007220 Notch receptor processing
GO:0009986 cell surface
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0030018 Z disc
GO:0030426 growth cone
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031594 neuromuscular junction
GO:0032991 protein-containing complex
GO:0034205 amyloid-beta formation
GO:0035253 ciliary rootlet
GO:0035333 Notch receptor processing, ligand-dependent
GO:0035556 intracellular signal transduction
GO:0042500 aspartic endopeptidase activity, intramembrane cleaving
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043198 dendritic shaft
GO:0045121 membrane raft
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0050435 amyloid-beta metabolic process
GO:0070765 gamma-secretase complex
GO:0110097 regulation of calcium import into the mitochondrion
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering

Diseases

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Interactions

118 interactions

InteractorPartnerSourcesPublicationsLink
PSEN2FHL2BioGRID, HPRD, MINT11001931 details
PSEN2FLNBBioGRID, HPRD, MINT9437013 details
PSEN2FLNAHPRD, MINT9437013 details
PSEN2BCL2L1BioGRID, HPRD, MINT10446169 details
PSEN2SRIBioGRID, HPRD, MINT10748169 details
PSEN2UBQLN1BioGRID, HPRD, MINT11076969 16813565 17614368 details
PSEN2CIB1BioGRID, HPRD, MINT10366599 details
PSEN2APPBioGRID, HPRD, IntAct10078972 21163940 32814053 9223340 details
PSEN2ECSITBioGRID, IntAct21163940 details
PSEN2PDCD4BioGRID, IntAct21163940 details
PSEN2DYNC1H1BioGRID, IntAct21163940 details
PSEN2EID1BioGRID, IntAct21163940 details
PSEN2MAST1BioGRID, IntAct21163940 details
PSEN2PSEN1BioGRID, IntAct12471034 15474363 21163940 details
PSEN2RNF32BioGRID, IntAct21163940 details
PSEN2LIPFBioGRID, IntAct21163940 details
PSEN2DNAJB1BioGRID, IntAct21163940 details
PSEN2EXOC6BioGRID, IntAct21163940 details
PSEN2FBXL12BioGRID, IntAct21163940 details
PSEN2RHEBBioGRID, IntAct21163940 details
PSEN2HLA-DMBBioGRID, IntAct29997244 details
PSEN2NEBLIntAct32814053 details
PSEN2PDZK1IP1IntAct32814053 details
PSEN2MICAL2IntAct32814053 details
PSEN2SOX14IntAct32814053 details
PSEN2H3C1IntAct32814053 details
PSEN2H3C4IntAct32814053 details
PSEN2H3C3IntAct32814053 details
PSEN2H3C6IntAct32814053 details
PSEN2H3C11IntAct32814053 details
PSEN2H3C8IntAct32814053 details
PSEN2H3C12IntAct32814053 details
PSEN2H3C10IntAct32814053 details
PSEN2H3C2IntAct32814053 details
PSEN2H3C7IntAct32814053 details
PSEN2SLC6A13IntAct32814053 details
PSEN2RNF2IntAct32814053 details
PSEN2PIK3R1IntAct32814053 details
PSEN2MNDAIntAct32814053 details
PSEN2FTLIntAct32814053 details
PSEN2CASP1HPRD, IntAct10069390 32814053 9219695 9990034 details
PSEN2BAK1IntAct32814053 details
PSEN2AK2IntAct32814053 details
PSEN2UBAC1IntAct32814053 details
PSEN2ELL2IntAct32814053 details
PSEN2RYBPIntAct32814053 details
PSEN2SP6IntAct32814053 details
PSEN2WDR61IntAct32814053 details
PSEN2FOXD4L6IntAct32814053 details
PSEN2ARL16IntAct32814053 details
PSEN2ZSCAN1IntAct32814053 details
PSEN2ZNF366IntAct32814053 details
PSEN2ZMAT2IntAct32814053 details
PSEN2SGSM1IntAct32814053 details
PSEN2MRFAP1L1IntAct32814053 details
PSEN2HNRNPLLIntAct32814053 details
PSEN2MGARPIntAct32814053 details
PSEN2ZXDCIntAct32814053 details
PSEN2CAPN1BioGRID, HPRD10677567 9852298 details
PSEN2KCNIP3BioGRID, HPRD11278424 9771752 details
PSEN2GFAPBioGRID12058025 details
PSEN2ICAM5BioGRID, HPRD11719200 details
PSEN2KCNIP4BioGRID, HPRD11847232 details
PSEN2NOS3BioGRID21163940 details
PSEN2CEP55BioGRID21163940 details
PSEN2ELAVL1BioGRID21163940 details
PSEN2EVI5LBioGRID21163940 details
PSEN2GCDHBioGRID21163940 details
PSEN2IFIT3BioGRID21163940 details
PSEN2IFIT5BioGRID21163940 details
PSEN2OGABioGRID21163940 details
PSEN2SPC24BioGRID21163940 details
PSEN2AAMPBioGRID21163940 details
PSEN2ACTG1BioGRID21163940 details
PSEN2CHKABioGRID21163940 details
PSEN2ECDBioGRID21163940 details
PSEN2HPS1BioGRID21163940 details
PSEN2AP1G1BioGRID27293189 details
PSEN2CSNK1A1BioGRID, HPRD27293189 8972483 details
PSEN2CSNK2A1BioGRID, HPRD27293189 8972483 9558331 9990034 details
PSEN2AURKABioGRID27293189 details
PSEN2RAB11AHPRD10369872 details
PSEN2METTL2BHPRD11738826 details
PSEN2DOCK3HPRD10854253 details
PSEN2TMBIM6UniProt30559186 details
PSEN2APBA1BioGRID12196555 details
PSEN2APBA2BioGRID12196555 details
PSEN2APBA3BioGRID12196555 details
PSEN2APH1ABioGRID, HPRD12297508 12471034 15474363 details
PSEN2NCSTNBioGRID, HPRD10993067 12297508 15474363 details
PSEN2PSENENBioGRID, HPRD12198112 12639958 15474363 22074918 details
PSEN2TRAF6BioGRID18996842 23707529 details
PSEN2PSEN2BioGRID15474363 details
PSEN2APH1BBioGRID, HPRD12297508 15474363 details
PSEN2FKBP8BioGRID15905180 details
PSEN2BCL2BioGRID15905180 details
PSEN2CASP3HPRD10069390 9219695 9990034 details
PSEN2CSNK1DHPRD8972483 9558331 9990034 details
PSEN2CASP6HPRD10069390 9219695 9990034 details
PSEN2CASP7HPRD10069390 9219695 9990034 details
PSEN2CASP8HPRD10069390 9219695 9990034 details
PSEN2CFLARHPRD10069390 9219695 9990034 details
PSEN2CTNND2HPRD10037471 details
PSEN2CTNNB1HPRD10037471 details
PSEN2NOTCH4HPRD11518718 details
PSEN2NOTCH1HPRD11518718 details
PSEN2NOTCH2HPRD11518718 details
PSEN2NOTCH3HPRD11518718 details
PSEN2CLK1BioGRID, IntAct26496610 details
PSEN2RNF115BioGRID, IntAct28514442 details
PSEN2NPLOC4BioGRID, IntAct28514442 details
PSEN2TSPAN5BioGRID26186194 details
PSEN2DLK1BioGRID26186194 details
PSEN2ART3BioGRID26186194 details
PSEN2ERGIC3BioGRID26186194 details
PSEN2FAF2BioGRID26186194 details
PSEN2KIF22BioGRID26496610 details
PSEN2PPP5CBioGRID26496610 details