Entity Details

Primary name PTGIS
Entity type gene
Source Source Link

Details

PrimaryID5740
RefseqGeneNG_007940
SymbolPTGIS
Nameprostaglandin I2 synthase
Chromosome20
Location20q13.13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPTGIS_HUMAN

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0006690 icosanoid metabolic process
GO:0008116 prostaglandin-I synthase activity
GO:0016021 integral component of membrane
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019371 cyclooxygenase pathway
GO:0020037 heme binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
GO:1900119 positive regulation of execution phase of apoptosis

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
PTGISAPPBioGRID21832049 details
PTGISPTGS2BioGRID21035466 details
PTGISPTGS1BioGRID21035466 details
PTGISCAV1BioGRID11339822 details
PTGISVIMBioGRID, IntAct30021884 details
PTGISKDM5BIntAct24937458 details