Entity Details

Primary name PTPN2
Entity type gene
Source Source Link

Details

PrimaryID5771
RefseqGeneNG_029116
SymbolPTPN2
Nameprotein tyrosine phosphatase non-receptor type 2
Chromosome18
Location18p11.21
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPTN2_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008285 negative regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 negative regulation of lipid storage
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030971 receptor tyrosine kinase binding
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042593 glucose homeostasis
GO:0045650 negative regulation of macrophage differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050922 negative regulation of chemotaxis
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:0097677 STAT family protein binding
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 negative regulation of positive thymic T cell selection
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903899 positive regulation of PERK-mediated unfolded protein response
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Diseases

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Interactions

183 interactions

InteractorPartnerSourcesPublicationsLink
PTPN2WASLIntAct16293614 details
PTPN2GHRBioGRID, HPRD, IntAct12907755 details
PTPN2TMED9BioGRID, UniProt16595549 details
PTPN2TMED10BioGRID, UniProt16595549 details
PTPN2ITGA1HPRD, MINT15592458 details
PTPN2HMGB1UniProt31694235 details
PTPN2STAT3BioGRID, HPRD12359225 15588985 26026268 29386185 31488827 details
PTPN2SRCBioGRID, HPRD15696169 details
PTPN2STAT6BioGRID17210636 details
PTPN2OCLNBioGRID26090670 details
PTPN2UBCBioGRID28190767 details
PTPN2EGFRBioGRID, HPRD11514572 15588985 9488479 details
PTPN2SHC1BioGRID, HPRD15588985 9488479 details
PTPN2FAM220ABioGRID26026268 details
PTPN2KPNB1BioGRID, HPRD9261175 details
PTPN2STX17BioGRID23006999 details
PTPN2GJB1BioGRID30401746 details
PTPN2SFNBioGRID, MINT15778465 details
PTPN2GOLGB1UniProt16595549 details
PTPN2LMAN1UniProt16595549 details
PTPN2INSRHPRD, MINT12612081 15192089 15588985 details
PTPN2STAT1BioGRID, HPRD12138178 12171910 14600148 19171783 details
PTPN2TRAF2BioGRID15696169 details
PTPN2ST7BioGRID29395067 details
PTPN2PDGFRBHPRD14966296 15588985 details
PTPN2JAK3HPRD11909529 15588985 details
PTPN2STAT5AHPRD11773439 15588985 details
PTPN2STAT5BHPRD11773439 15588985 details
PTPN2FKBP4HPRD15509512 details
PTPN2CDK1HPRD15030318 details
PTPN2CDK2HPRD15030318 details
PTPN2CDK5HPRD15030318 details
PTPN2JAK1HPRD11909529 15588985 details
PTPN2CDC42IntAct16293614 details
PTPN2UCHL5BioGRID, IntAct19615732 details
PTPN2PSMD14BioGRID, IntAct26496610 28675297 details
PTPN2PSMC1BioGRID, IntAct26496610 27880917 28675297 details
PTPN2TMEM17BioGRID, IntAct26638075 details
PTPN2TCTN2BioGRID, IntAct26638075 details
PTPN2TMEM216BioGRID, IntAct26638075 details
PTPN2TMOD3BioGRID, IntAct28330616 details
PTPN2DBN1BioGRID, IntAct28330616 details
PTPN2EIF5ABioGRID, IntAct28330616 details
PTPN2CORO1CBioGRID, IntAct28330616 details
PTPN2TPM4BioGRID, IntAct28330616 details
PTPN2MYO1CBioGRID, IntAct28330616 details
PTPN2PTPN1BioGRID, IntAct28330616 32877691 details
PTPN2SLC39A5BioGRID, IntAct28514442 details
PTPN2C3AR1BioGRID, IntAct28514442 details
PTPN2SLC39A4BioGRID, IntAct26186194 28514442 details
PTPN2C5AR2BioGRID, IntAct28514442 details
PTPN2TNFSF8BioGRID, IntAct28514442 details
PTPN2B4GAT1BioGRID, IntAct28514442 details
PTPN2ASGR1BioGRID, IntAct28514442 details
PTPN2COL5A1BioGRID, IntAct26186194 28514442 details
PTPN2HNRNPMBioGRID, IntAct30021884 details
PTPN2MOSPD2UniProt29858488 details
PTPN2KATNB1BioGRID22939629 details
PTPN2HSPD1BioGRID22939629 details
PTPN2BAG3BioGRID23824909 details
PTPN2METTL13BioGRID26344197 details
PTPN2PTPN6BioGRID26344197 details
PTPN2VARS1BioGRID26344197 details
PTPN2APLP2BioGRID27880917 28675297 details
PTPN2APPBioGRID27880917 details
PTPN2CALUBioGRID27880917 details
PTPN2GOLM2BioGRID27880917 details
PTPN2CSPG5BioGRID27880917 details
PTPN2GOLIM4BioGRID27880917 details
PTPN2HADHABioGRID27880917 details
PTPN2HARS1BioGRID27880917 details
PTPN2HMGN5BioGRID27880917 details
PTPN2KPNA1BioGRID27432908 27880917 28675297 details
PTPN2KPNA6BioGRID27432908 27880917 28675297 details
PTPN2NUP50BioGRID27880917 28675297 details
PTPN2PSMC2BioGRID27880917 28675297 details
PTPN2PSMC4BioGRID27880917 28675297 details
PTPN2PSMC5BioGRID27880917 28675297 details
PTPN2PSMC6BioGRID27880917 28675297 details
PTPN2PSMD1BioGRID27880917 28675297 details
PTPN2PSMD10BioGRID27880917 28675297 details
PTPN2PSMD2BioGRID27880917 28675297 details
PTPN2PSMD4BioGRID27880917 28675297 details
PTPN2PSMD6BioGRID27880917 28675297 details
PTPN2SETD7BioGRID27880917 details
PTPN2PTPN20BioGRID27432908 details
PTPN2KPNA5BioGRID27432908 28675297 details
PTPN2ANP32CBioGRID27432908 details
PTPN2ANP32BBioGRID27432908 28675297 details
PTPN2TXNDC5BioGRID27432908 details
PTPN2NMNAT1BioGRID27432908 details
PTPN2ANP32EBioGRID27432908 details
PTPN2TRMT61BBioGRID27432908 details
PTPN2RCL1BioGRID27432908 details
PTPN2BRIX1BioGRID27432908 details
PTPN2GAR1BioGRID27432908 details
PTPN2PNO1BioGRID27432908 details
PTPN2GADD45GIP1BioGRID27432908 details
PTPN2ZC3HAV1LBioGRID27432908 details
PTPN2DIMT1BioGRID27432908 details
PTPN2NSUN5BioGRID27432908 details
PTPN2DNAJC10BioGRID27432908 details
PTPN2C8orf33BioGRID27432908 details
PTPN2MRM3BioGRID27432908 details
PTPN2G3BP1BioGRID27432908 details
PTPN2FTSJ3BioGRID27432908 details
PTPN2EIF2S1BioGRID27432908 details
PTPN2BYSLBioGRID27432908 details
PTPN2PSMD13BioGRID27432908 28675297 details
PTPN2RBM34BioGRID27432908 details
PTPN2CASKIN1BioGRID27432908 details
PTPN2PSMC3IPBioGRID27432908 details
PTPN2GTPBP10BioGRID27432908 details
PTPN2PSMD8BioGRID27432908 28675297 details
PTPN2RPL3LBioGRID27432908 details
PTPN2TFB1MBioGRID27432908 details
PTPN2RPP30BioGRID27432908 details
PTPN2DUSP10BioGRID27432908 details
PTPN2EXOSC4BioGRID27432908 details
PTPN2GRSF1BioGRID27432908 details
PTPN2UBE3ABioGRID22645313 details
PTPN2CA9BioGRID28692057 details
PTPN2ADRM1BioGRID28675297 details
PTPN2AHCYL1BioGRID28675297 details
PTPN2ANKRD52BioGRID28675297 details
PTPN2LRPPRCBioGRID28675297 details
PTPN2NUP153BioGRID28675297 details
PTPN2PAAF1BioGRID28675297 details
PTPN2PSMA1BioGRID28675297 details
PTPN2PSMA2BioGRID28675297 details
PTPN2PSMA3BioGRID28675297 details
PTPN2PSMA4BioGRID28675297 details
PTPN2PSMA5BioGRID28675297 details
PTPN2PSMA6BioGRID28675297 details
PTPN2PSMB1BioGRID28675297 details
PTPN2PSMB2BioGRID28675297 details
PTPN2PSMB3BioGRID28675297 details
PTPN2PSMB4BioGRID28675297 details
PTPN2PSMB5BioGRID28675297 details
PTPN2PSMB7BioGRID28675297 details
PTPN2PSMC3BioGRID28675297 details
PTPN2PSMD11BioGRID28675297 details
PTPN2PSMD12BioGRID28675297 details
PTPN2PSMD3BioGRID28675297 details
PTPN2PSMD7BioGRID28675297 details
PTPN2TXNL1BioGRID28675297 details
PTPN2UBE3CBioGRID28675297 details
PTPN2USP47BioGRID28675297 details
PTPN2OTULINLBioGRID31056421 details
PTPN2TRIM28BioGRID29955894 details
PTPN2PLEKHA4BioGRID31091453 details
PTPN2SEC61BBioGRID32788342 34079125 details
PTPN2BRD4BioGRID32416067 details
PTPN2FAM20CBioGRID32149426 details
PTPN2DNAJC16BioGRID33957083 details
PTPN2DNAJC1BioGRID33957083 details
PTPN2DNAJC25BioGRID33957083 details
PTPN2SEC63BioGRID33957083 details
PTPN2ATP2A1BioGRID34079125 details
PTPN2BCAP31BioGRID34079125 details
PTPN2CKAP4BioGRID34079125 details
PTPN2DERL1BioGRID34079125 details
PTPN2ELOVL5BioGRID34079125 details
PTPN2EMDBioGRID34079125 details
PTPN2ERGIC1BioGRID34079125 details
PTPN2ERGIC2BioGRID34079125 details
PTPN2GJD3BioGRID34079125 details
PTPN2H2BC8BioGRID34079125 details
PTPN2HSD17B11BioGRID34079125 details
PTPN2HSD3B7BioGRID34079125 details
PTPN2LMNABioGRID34079125 details
PTPN2LNPKBioGRID34079125 details
PTPN2LRRC59BioGRID34079125 details
PTPN2METTL7ABioGRID34079125 details
PTPN2NUP155BioGRID34079125 details
PTPN2PANX1BioGRID34079125 details
PTPN2PXMP2BioGRID34079125 details
PTPN2RAB9ABioGRID34079125 details
PTPN2RPN1BioGRID34079125 details
PTPN2RPN2BioGRID34079125 details
PTPN2SEC62BioGRID34079125 details
PTPN2SSR1BioGRID34079125 details
PTPN2TMPOBioGRID34079125 details