Entity Details

Primary name PTPRC
Entity type gene
Source Source Link

Details

PrimaryID5788
RefseqGeneNG_007730
SymbolPTPRC
Nameprotein tyrosine phosphatase receptor type C
Chromosome1
Location1q31.3-q32.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-20
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPTPRC_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001779 natural killer cell differentiation
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 leukocyte cell-cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0008201 heparin binding
GO:0009897 external side of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0009986 cell surface
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0016311 dephosphorylation
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030506 ankyrin binding
GO:0030507 spectrin binding
GO:0030667 secretory granule membrane
GO:0030890 positive regulation of B cell proliferation
GO:0031668 cellular response to extracellular stimulus
GO:0031953 negative regulation of protein autophosphorylation
GO:0032059 bleb
GO:0032677 regulation of interleukin-8 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034113 heterotypic cell-cell adhesion
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0043312 neutrophil degranulation
GO:0043395 heparan sulfate proteoglycan binding
GO:0043410 positive regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0044855 plasma membrane raft distribution
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045121 membrane raft
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048539 bone marrow development
GO:0048864 stem cell development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0098857 membrane microdomain
GO:1903615 positive regulation of protein tyrosine phosphatase activity
GO:1903979 negative regulation of microglial cell activation
GO:1904155 DN2 thymocyte differentiation
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:2000473 positive regulation of hematopoietic stem cell migration
GO:2000648 positive regulation of stem cell proliferation
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

82 interactions

InteractorPartnerSourcesPublicationsLink
PTPRCLCKBioGRID, DIP, HPRD, IntAct, MINT10330160 10369126 11369760 12589038 14625311 15085197 19167335 24463463 7507203 8473339 8576115 8663450 9533446 9973453 details
PTPRCPTPRCBioGRID, HPRD, MINT10683443 15978577 details
PTPRCCDH2IntAct19167335 details
PTPRCTECIntAct19167335 details
PTPRCERBB2IntAct19167335 details
PTPRCPDGFRBIntAct19167335 details
PTPRCMETIntAct19167335 details
PTPRCPXNIntAct19167335 details
PTPRCCTNNB1IntAct, MINT12370829 19167335 details
PTPRCINSRHPRD, IntAct1373652 19167335 details
PTPRCTIE1IntAct19167335 details
PTPRCCSKIntAct, MINT19167335 7507203 details
PTPRCGAB1IntAct19167335 details
PTPRCGRIN2BIntAct19167335 details
PTPRCNTRK1IntAct19167335 details
PTPRCPDPK1IntAct19167335 details
PTPRCNSFIntAct19167335 details
PTPRCGHRIntAct19167335 details
PTPRCEPORIntAct19167335 details
PTPRCEGFRIntAct19167335 31980649 details
PTPRCMAPK3IntAct19167335 details
PTPRCTEKIntAct19167335 details
PTPRCWASIntAct19167335 details
PTPRCTNK2IntAct19167335 details
PTPRCCBLIntAct19167335 details
PTPRCLEPRIntAct19167335 details
PTPRCPKP4IntAct19167335 details
PTPRCITGALBioGRID, HPRD, MINT15946252 details
PTPRCLGALS1BioGRID, HPRD, MINT10369126 10490978 details
PTPRCUHRF2BioGRID, UniProt21952639 details
PTPRCSKAP1BioGRID, HPRD11909961 details
PTPRCGANABBioGRID, HPRD10921916 11564800 9148925 details
PTPRCPTPRCAPBioGRID, HPRD7499298 8537410 details
PTPRCCD2BioGRID, HPRD1970422 1976695 details
PTPRCCD8ABioGRID, HPRD1834739 details
PTPRCCD4BioGRID, HPRD1834739 details
PTPRCCD247BioGRID, HPRD7526385 details
PTPRCLYNBioGRID, HPRD10415030 12393728 7516335 details
PTPRCRNF11BioGRID, HPRD15231748 details
PTPRCFYNBioGRID, HPRD12589038 14625311 8980254 9368621 9535845 details
PTPRCSRCBioGRID14625311 details
PTPRCMAPK1BioGRID10415025 details
PTPRCSEMA4DBioGRID, HPRD, MINT10648410 11254687 8955171 details
PTPRCCD22BioGRID, HPRD, MINT10228003 10648410 7537381 details
PTPRCCD244IntAct23346089 details
PTPRCCXCR4HPRD, MINT12519755 21912642 details
PTPRCPAEPBioGRID, HPRD12556471 details
PTPRCPRKCSHBioGRID, HPRD9148925 details
PTPRCPLK3BioGRID11551930 details
PTPRCSLAMF1BioGRID10229804 details
PTPRCCD44BioGRID9573028 details
PTPRCCD79ABioGRID7516335 details
PTPRCCD79BBioGRID7516335 details
PTPRCCD1DBioGRID, HPRD10473580 details
PTPRCU2AF2BioGRID26641092 details
PTPRCMAPK14BioGRID10415025 details
PTPRCGRB2HPRD8570203 details
PTPRCCSNK2A1HPRD10066810 details
PTPRCCSNK2A2HPRD10066810 details
PTPRCIFNAR1HPRD9403695 details
PTPRCEZRHPRD12560083 details
PTPRCRASA1HPRD8570203 details
PTPRCFCGR3AHPRD8157290 details
PTPRCIRS1HPRD8557683 details
PTPRCJAK1HPRD11201744 details
PTPRCJAK2HPRD11201744 details
PTPRCMBL2HPRD11564800 details
PTPRCPTPN6HPRD10228003 9368621 details
PTPRCTYK2HPRD11201744 details
PTPRCZAP70HPRD7737297 details
PTPRCCD28HPRD1355979 details
PTPRCDPP4HPRD1680916 details
PTPRCJAK3HPRD11994288 details
PTPRCLCP2HPRD8703037 details
PTPRCPPFIBP2HPRD9624153 details
PTPRCLSM1HPRD8980254 details
PTPRCANP32AHPRD1655467 details
PTPRCPPFIA1HPRD9624153 details
PTPRCCD177UniProt21193407 details
PTPRCFBXO6BioGRID22268729 details
PTPRCATG16L1BioGRID30196744 details
PTPRCRMC1BioGRID33144569 details