Entity Details

Primary name NOD2
Entity type gene
Source Source Link

Details

PrimaryID64127
RefseqGeneNG_007508
SymbolNOD2
Namenucleotide binding oligomerization domain containing 2
Chromosome16
Location16q12.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-12-03
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsNOD2_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002221 pattern recognition receptor signaling pathway
GO:0002227 innate immune response in mucosa
GO:0002253 activation of immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002710 negative regulation of T cell mediated immunity
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0002830 positive regulation of type 2 immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0003779 actin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006952 defense response
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007254 JNK cascade
GO:0007584 response to nutrient
GO:0009595 detection of biotic stimulus
GO:0009986 cell surface
GO:0016045 detection of bacterium
GO:0016323 basolateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030544 Hsp70 protein binding
GO:0031982 vesicle
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032495 response to muramyl dipeptide
GO:0032498 detection of muramyl dipeptide
GO:0032500 muramyl dipeptide binding
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032701 negative regulation of interleukin-18 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0035556 intracellular signal transduction
GO:0038187 pattern recognition receptor activity
GO:0042742 defense response to bacterium
GO:0042834 peptidoglycan binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045335 phagocytic vesicle
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046645 positive regulation of gamma-delta T cell activation
GO:0046658 anchored component of plasma membrane
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050700 CARD domain binding
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051879 Hsp90 protein binding
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0071407 cellular response to organic cyclic compound
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0090022 regulation of neutrophil chemotaxis
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1904417 positive regulation of xenophagy
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000363 positive regulation of prostaglandin-E synthase activity

Diseases

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Interactions

99 interactions

InteractorPartnerSourcesPublicationsLink
NOD2RIPK2BioGRID, HPRD, IntAct, MINT11087742 15620648 19592251 21097508 21123652 21931826 22607974 22829933 26670046 27545878 27812135 details
NOD2ATG16L1BioGRID, MINT19898471 23376921 27273576 details
NOD2TRIM27BioGRID, IntAct22829933 details
NOD2TRIM8IntAct22829933 details
NOD2TRIM50IntAct22829933 details
NOD2VIMBioGRID, IntAct21699783 22684479 27812135 details
NOD2GALNT2BioGRID, IntAct21699783 details
NOD2FIS1BioGRID, IntAct21699783 details
NOD2TLE1BioGRID, IntAct21699783 details
NOD2KAT5BioGRID, IntAct21699783 details
NOD2PPP2R5EBioGRID, IntAct21699783 details
NOD2NDUFA13IntAct15753091 details
NOD2ERBINBioGRID, HPRD, IntAct16203728 30833792 details
NOD2XIAPBioGRID, DIP, IntAct19667203 22607974 23818254 details
NOD2MAP3K7BioGRID15075345 17348859 17965022 details
NOD2IRGMBioGRID25891078 details
NOD2C10orf67BioGRID27812135 details
NOD2DOCK7BioGRID27812135 details
NOD2DCTN1BioGRID27812135 details
NOD2GOLGB1BioGRID27812135 details
NOD2PRR16BioGRID27812135 details
NOD2ANKHD1BioGRID27812135 details
NOD2TRIM41BioGRID27812135 details
NOD2CHMP5BioGRID27812135 details
NOD2ENTR1BioGRID27812135 details
NOD2IKBIPBioGRID27812135 details
NOD2KRT15BioGRID27812135 details
NOD2PPP1R12CBioGRID27812135 details
NOD2LDOC1BioGRID27812135 details
NOD2PPP2R3BBioGRID27812135 details
NOD2CHMP4BBioGRID27812135 details
NOD2PDLIM5BioGRID27812135 details
NOD2TACC3BioGRID27812135 details
NOD2HAP1BioGRID27812135 details
NOD2ANXA2BioGRID27812135 details
NOD2LURAP1LBioGRID27812135 details
NOD2RPL13ABioGRID27812135 details
NOD2ALPIBioGRID27812135 details
NOD2VCPBioGRID27812135 details
NOD2LMNABioGRID27812135 details
NOD2WBP11BioGRID27812135 details
NOD2TNIP1BioGRID27812135 details
NOD2TPM1BioGRID27812135 details
NOD2TPM3BioGRID27812135 details
NOD2TPM4BioGRID27812135 details
NOD2SCYL1BioGRID27812135 details
NOD2CCL13BioGRID27812135 details
NOD2ANKRD17MINT23711367 details
NOD2SUGT1BioGRID, DIP17420470 details
NOD2CASP1BioGRID, DIP15107016 18511561 details
NOD2CASP4DIP18511561 details
NOD2NLRP1DIP18511561 details
NOD2OLFM4DIP20534456 details
NOD2SLC15A3DIP24695226 details
NOD2SLC15A4DIP24695226 details
NOD2SQSTM1BioGRID, IntAct23437331 30833792 details
NOD2HSPB8DIP31273097 details
NOD2SHARPINBioGRID, IntAct22607974 23818254 26670046 details
NOD2RBCK1BioGRID, IntAct22607974 23818254 26670046 details
NOD2RNF31BioGRID, IntAct22607974 23818254 26670046 27545878 details
NOD2NLRC4BioGRID, HPRD11472070 15107016 details
NOD2BIRC2BioGRID22607974 details
NOD2BIRC3BioGRID22607974 details
NOD2NAT16BioGRID22607974 details
NOD2IKBKGBioGRID22607974 details
NOD2RIPK1BioGRID22607974 details
NOD2CASP12BioGRID18329614 details
NOD2COPS6BioGRID17337451 details
NOD2TRAF4BioGRID21097508 details
NOD2TRAF6BioGRID23437331 details
NOD2NOD2BioGRID23437331 details
NOD2NOD1BioGRID19898471 details
NOD2UBCBioGRID23300079 details
NOD2CYLDBioGRID26670046 27545878 details
NOD2TNFAIP3BioGRID26670046 details
NOD2SPATA2BioGRID27545878 details
NOD2PRKNBioGRID30378174 details
NOD2SRPRBBioGRID, IntAct30833792 details
NOD2TMED9BioGRID, IntAct30833792 details
NOD2TMED1BioGRID, IntAct30833792 details
NOD2TWF1BioGRID, IntAct30833792 details
NOD2BST2BioGRID, IntAct30833792 details
NOD2SLC25A3BioGRID, IntAct30833792 details
NOD2PPP2R2ABioGRID, IntAct30833792 details
NOD2RPL37ABioGRID, IntAct30833792 details
NOD2TMED10BioGRID, IntAct30833792 details
NOD2RPL34BioGRID, IntAct30833792 details
NOD2HADHABioGRID, IntAct30833792 details
NOD2DNAJA1BioGRID, IntAct30833792 details
NOD2PPP2R1ABioGRID, IntAct30833792 details
NOD2MYL9BioGRID, IntAct30833792 details
NOD2TCP1BioGRID, IntAct30833792 details
NOD2CLTABioGRID, IntAct30833792 details
NOD2MYL3IntAct30833792 details
NOD2ACSL3BioGRID, IntAct30833792 details
NOD2SPTLC1BioGRID, IntAct30833792 details
NOD2TMED2BioGRID30833792 details
NOD2VDAC2BioGRID30833792 details
NOD2RELAIntAct20436512 details