Entity Details

Primary name TGFBR1
Entity type gene
Source Source Link

Details

PrimaryID7046
RefseqGeneNG_007461
SymbolTGFBR1
Nametransforming growth factor beta receptor 1
Chromosome9
Location9q22.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-18
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsTGFR1_HUMAN

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001824 blastocyst development
GO:0001837 epithelial to mesenchymal transition
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002088 lens development in camera-type eye
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008284 positive regulation of cell population proliferation
GO:0008354 germ cell migration
GO:0008584 male gonad development
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0009986 cell surface
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 membrane
GO:0016361 activin receptor activity, type I
GO:0016579 protein deubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030199 collagen fibril organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031396 regulation of protein ubiquitination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032924 activin receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0042060 wound healing
GO:0042118 endothelial cell activation
GO:0043062 extracellular structure organization
GO:0043235 receptor complex
GO:0043393 regulation of protein binding
GO:0043542 endothelial cell migration
GO:0045121 membrane raft
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048179 activin receptor complex
GO:0048185 activin binding
GO:0048538 thymus development
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048762 mesenchymal cell differentiation
GO:0048844 artery morphogenesis
GO:0048870 cell motility
GO:0050431 transforming growth factor beta binding
GO:0051272 positive regulation of cellular component movement
GO:0051491 positive regulation of filopodium assembly
GO:0051496 positive regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060017 parathyroid gland development
GO:0060021 roof of mouth development
GO:0060037 pharyngeal system development
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060978 angiogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0070411 I-SMAD binding
GO:0070723 response to cholesterol
GO:0071363 cellular response to growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905075 positive regulation of tight junction disassembly
GO:1905223 epicardium morphogenesis
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

207 interactions

InteractorPartnerSourcesPublicationsLink
TGFBR1FKBP1ABioGRID, HPRD, IntAct10025408 16049346 24658140 7518616 7791754 9346894 details
TGFBR1SMAD2BioGRID, HPRD, MINT11102446 12543979 15350225 18511908 19139564 25872870 29490279 9346908 9525694 9892009 details
TGFBR1STRAPBioGRID, HPRD, IntAct10757800 17314099 9856985 details
TGFBR1TGFB1BioGRID, HPRD, I2D10716993 15597342 20856203 8235612 details
TGFBR1ACVR1HPRD, IntAct15761153 24658140 details
TGFBR1TGFBR2BioGRID, DIP, HPRD11102446 11483955 19556242 19758997 21791611 23868260 25825445 7890683 8576253 details
TGFBR1LRG1DIP23868260 details
TGFBR1ENGBioGRID, DIP, HPRD12015308 15702480 18974388 23868260 9872992 details
TGFBR1BMPR2BioGRID7791754 7890683 details
TGFBR1SMAD7BioGRID, HPRD10757800 11163210 12151385 14657019 14722617 15148321 15359284 15946939 16027725 17314099 19758997 20663871 21791611 22624557 23027871 25149540 31746425 9215638 9335507 details
TGFBR1FNTABioGRID, HPRD8530343 details
TGFBR1AP2B1BioGRID, HPRD12429842 details
TGFBR1CD44BioGRID, HPRD12145287 15597342 details
TGFBR1PPP2R2ABioGRID, HPRD9774674 details
TGFBR1CLUBioGRID, HPRD8555189 details
TGFBR1TRAF6BioGRID, HPRD18758450 18922473 24103590 25622187 26807171 details
TGFBR1HSP90AA1BioGRID18591668 21465483 22848678 details
TGFBR1SKIBioGRID20959473 details
TGFBR1TSC22D1BioGRID21791611 details
TGFBR1USP4BioGRID22706160 30335615 details
TGFBR1MYOCBioGRID, HPRD16289162 details
TGFBR1BAMBIBioGRID19758997 details
TGFBR1SMAD3BioGRID, HPRD12543979 19758997 25872870 9311995 details
TGFBR1PAK1BioGRID, HPRD15761153 details
TGFBR1NRP1BioGRID20675371 21186301 details
TGFBR1RANBP9BioGRID24103590 details
TGFBR1OTUB1BioGRID25872870 details
TGFBR1TGFBRAP1BioGRID, HPRD11278302 9545258 details
TGFBR1APPL1BioGRID26583432 details
TGFBR1FKBP1BBioGRID16049346 details
TGFBR1PSMD14BioGRID30745168 details
TGFBR1USP2BioGRID29490279 details
TGFBR1MYT1LBioGRID29490279 details
TGFBR1TRAP1HPRD11278302 9545258 details
TGFBR1YWHAZIntAct19732720 details
TGFBR1TGFB3HPRD, MINT11850637 12060054 12607775 21423151 details
TGFBR1ITGA5MINT22940691 details
TGFBR1DLG5MINT23624079 details
TGFBR1MAP3K20BioGRID, HPRD15465036 details
TGFBR1SMURF1BioGRID11278251 12857866 14657019 details
TGFBR1SMURF2BioGRID, HPRD11163210 14722617 21791611 22624557 23973329 25149540 26679521 31746425 details
TGFBR1PIK3R1BioGRID, HPRD15657037 9435577 details
TGFBR1PIK3R2BioGRID, HPRD9435577 details
TGFBR1SNX6BioGRID, HPRD11279102 details
TGFBR1CAV1BioGRID, HPRD11102446 30745168 details
TGFBR1SMAD4BioGRID, HPRD11102446 15761153 8774881 details
TGFBR1MAP3K7BioGRID, HPRD18758450 19556242 23973329 details
TGFBR1MAPK14BioGRID18758450 details
TGFBR1EP300BioGRID21629263 details
TGFBR1HSPA4BioGRID19995547 details
TGFBR1SKILBioGRID20959473 details
TGFBR1ITCHBioGRID15350225 details
TGFBR1HMMRBioGRID22610405 details
TGFBR1USP11BioGRID22773947 details
TGFBR1USP15BioGRID22344298 23973329 24850914 details
TGFBR1TOLLIPBioGRID23027871 details
TGFBR1SMAD6BioGRID, HPRD20663871 9335505 9436979 details
TGFBR1TAB2BioGRID19556242 details
TGFBR1CDC42BioGRID15761153 details
TGFBR1ARHGEF6BioGRID, HPRD15761153 details
TGFBR1KCNK18BioGRID, HPRD15761153 details
TGFBR1FBXO34BioGRID, HPRD15761153 details
TGFBR1OXSR1BioGRID, HPRD15761153 details
TGFBR1PPP1R16BBioGRID15761153 details
TGFBR1OCLNBioGRID, HPRD15761153 details
TGFBR1SPTBN1BioGRID12543979 details
TGFBR1ANK1BioGRID12543979 details
TGFBR1TPM1BioGRID12543979 details
TGFBR1PEG10BioGRID15611116 details
TGFBR1ACVRL1BioGRID, HPRD14580334 8242742 details
TGFBR1TRAF4BioGRID23973329 details
TGFBR1PSEN1BioGRID24399296 details
TGFBR1NOTCH1BioGRID24399296 details
TGFBR1PARD6ABioGRID, HPRD15761148 15761153 details
TGFBR1SH3KBP1BioGRID26169354 details
TGFBR1RASSF1BioGRID27292796 details
TGFBR1VHLBioGRID29662646 details
TGFBR1TGFBR1HPRD9472030 details
TGFBR1TGFB2HPRD11157754 details
TGFBR1AMHR2HPRD11420127 details
TGFBR1SMAD1HPRD10085121 9136927 9748228 details
TGFBR1BMPR1BHPRD11420127 details
TGFBR1ZFYVE9HPRD9865696 details
TGFBR1PMLHPRD15356634 details
TGFBR1CTNNB1HPRD12000714 details
TGFBR1ANAPC5HPRD15761153 details
TGFBR1ARL4DHPRD15761153 details
TGFBR1ARHGAP15HPRD15761153 details
TGFBR1ARL8BHPRD15761153 details
TGFBR1ASH2LHPRD15761153 details
TGFBR1AURKBHPRD15761153 details
TGFBR1BTBD2HPRD15761153 details
TGFBR1CDC20HPRD15761153 details
TGFBR1CDC42EP4HPRD15761153 details
TGFBR1CDK4HPRD15761153 details
TGFBR1CDK6HPRD15761153 details
TGFBR1CDKL1HPRD15761153 details
TGFBR1CHN1HPRD15761153 details
TGFBR1CHN2HPRD15761153 details
TGFBR1CHUKHPRD15761153 details
TGFBR1CSNK1A1HPRD15761153 details
TGFBR1CSNK2A2HPRD15761153 details
TGFBR1CUL5HPRD15761153 details
TGFBR1DAPK2HPRD15761153 details
TGFBR1PREX2HPRD15761153 details
TGFBR1DUSP13HPRD15761153 details
TGFBR1EIF2AK4HPRD15761153 details
TGFBR1ENC1HPRD15761153 details
TGFBR1FANCLHPRD15761153 details
TGFBR1FBXL12HPRD15761153 details
TGFBR1GNA13HPRD15761153 details
TGFBR1GNB2HPRD15761153 details
TGFBR1GNB3HPRD15761153 details
TGFBR1IKBKBHPRD15761153 details
TGFBR1DCAF6HPRD15761153 details
TGFBR1ITKHPRD15761153 details
TGFBR1KATNB1HPRD15761153 details
TGFBR1KLHL1HPRD15761153 details
TGFBR1LIMS1HPRD15761153 details
TGFBR1MYO3AHPRD15761153 details
TGFBR1NAT8HPRD15761153 details
TGFBR1NEK6HPRD15761153 details
TGFBR1NEK8HPRD15761153 details
TGFBR1NKIRAS1HPRD15761153 details
TGFBR1NUAK2HPRD15761153 details
TGFBR1NUP37HPRD15761153 details
TGFBR1CDK17HPRD15761153 details
TGFBR1CDK14HPRD15761153 details
TGFBR1PLEKHB1HPRD15761153 details
TGFBR1PLEKHPRD15761153 details
TGFBR1PLK4HPRD15761153 details
TGFBR1PPP3CCHPRD15761153 details
TGFBR1PPP6CHPRD15761153 details
TGFBR1PREBHPRD15761153 details
TGFBR1PRPF4HPRD15761153 details
TGFBR1RAB13HPRD15761153 details
TGFBR1RAB25HPRD15761153 details
TGFBR1RAB33BHPRD15761153 details
TGFBR1RAB38HPRD15761153 details
TGFBR1RAB3BHPRD15761153 details
TGFBR1RAB6BHPRD15761153 details
TGFBR1RANHPRD15761153 details
TGFBR1RAP2AHPRD15761153 details
TGFBR1RASD2HPRD15761153 details
TGFBR1RASL12HPRD15761153 details
TGFBR1RHEBL1HPRD15761153 details
TGFBR1RHOAHPRD15761153 details
TGFBR1RHODHPRD15761153 details
TGFBR1RHOGHPRD15761153 details
TGFBR1RHOHHPRD15761153 details
TGFBR1RHOJHPRD15761153 details
TGFBR1RHPN2HPRD15761153 details
TGFBR1RNF130HPRD15761153 details
TGFBR1RNF146HPRD15761153 details
TGFBR1RNF5HPRD15761153 details
TGFBR1RPS27AHPRD15761153 details
TGFBR1RRHHPRD15761153 details
TGFBR1RTKNHPRD15761153 details
TGFBR1SAMD8HPRD15761153 details
TGFBR1SAT2HPRD15761153 details
TGFBR1SKAP2HPRD15761153 details
TGFBR1SNTG1HPRD15761153 details
TGFBR1SOCS6HPRD15761153 details
TGFBR1STK35HPRD15761153 details
TGFBR1STUB1HPRD15761153 details
TGFBR1STX8HPRD15761153 details
TGFBR1STYXL1HPRD15761153 details
TGFBR1TNNT1HPRD15761153 details
TGFBR1TSSK1BHPRD15761153 details
TGFBR1TSSK4HPRD15761153 details
TGFBR1TTC1HPRD15761153 details
TGFBR1UBA52HPRD15761153 details
TGFBR1UBBHPRD15761153 details
TGFBR1UBDHPRD15761153 details
TGFBR1UBE2E3HPRD15761153 details
TGFBR1USP45HPRD15761153 details
TGFBR1VEPH1HPRD15761153 details
TGFBR1WDR13HPRD15761153 details
TGFBR1WDR33HPRD15761153 details
TGFBR1DCAF12HPRD15761153 details
TGFBR1WDR61HPRD15761153 details
TGFBR1XIAPHPRD11356828 details
TGFBR1RPAP3HPRD15761153 details
TGFBR1OSR1HPRD15761153 details
TGFBR1UBXN1HPRD15761153 details
TGFBR1KLHL35HPRD15761153 details
TGFBR1PLEKHJ1HPRD15761153 details
TGFBR1TTC27HPRD15761153 details
TGFBR1POMKHPRD15761153 details
TGFBR1TTPALHPRD15761153 details
TGFBR1ARHGAP31HPRD15761153 details
TGFBR1UBE2ZHPRD15761153 details
TGFBR1RGS19HPRD15761153 details
TGFBR1SQSTM1HPRD15761153 details
TGFBR1DAB2BioGRID, HPRD, UniProt11387212 details
TGFBR1NLGN3BioGRID, IntAct26496610 details
TGFBR1EPHA2BioGRID, IntAct26496610 details
TGFBR1GOLT1BBioGRID, IntAct26496610 details
TGFBR1CANXBioGRID, IntAct29568061 details
TGFBR1LAMP1BioGRID, IntAct29568061 details
TGFBR1HAVCR1BioGRID29742433 details
TGFBR1RETBioGRID32062451 details
TGFBR1RNF11BioGRID31985874 details
TGFBR1NPC1BioGRID33144569 details
TGFBR1ELAVL1BioGRID19322201 details
TGFBR1TRIM25BioGRID29117863 details
TGFBR1VIRMABioGRID29507755 details