Entity Details

Primary name SEM1
Entity type gene
Source Source Link

Details

PrimaryID7979
RefseqGeneNG_009273
SymbolSEM1
NameSEM1 26S proteasome subunit
Chromosome7
Location7q21.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-04-04
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSEM1_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006406 mRNA export from nucleus
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008541 proteasome regulatory particle, lid subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016579 protein deubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043248 proteasome assembly
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Diseases

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Interactions

146 interactions

InteractorPartnerSourcesPublicationsLink
SEM1BRCA2BioGRID, DIP, HPRD, IntAct, MINT, UniProt10373512 12228710 16205630 16239144 22293751 24013206 26145171 26833090 28976962 32609828 details
SEM1MAP1LC3BBioGRID, MINT21900206 details
SEM1NUDT21BioGRID, MINT21900206 details
SEM1USP14BioGRID, MINT24811749 28396413 details
SEM1PSMD3BioGRID, IntAct15610744 16239144 17563742 18775730 24515614 25416956 details
SEM1PCID2BioGRID, DIP, HPRD, IntAct16189514 16239144 22343721 24515614 32296183 details
SEM1DR1IntAct32814053 details
SEM1GRNIntAct32814053 details
SEM1GTF2BIntAct32814053 details
SEM1NF2IntAct32814053 details
SEM1GTF3C3IntAct32814053 details
SEM1JPH3IntAct32814053 details
SEM1SOD1IntAct32814053 details
SEM1FUSIntAct32814053 details
SEM1LRRK2IntAct32814053 details
SEM1PSMD6BioGRID17563742 18775730 24515614 details
SEM1BRCA1BioGRID17563742 24013206 details
SEM1RPA1BioGRID26145171 details
SEM1RAD51BioGRID26833090 28976962 details
SEM1RAD52BioGRID31799622 details
SEM1PSMC2BioGRID, MINT15610744 16239144 24811749 details
SEM1UBE3CBioGRID, MINT24811749 28396413 details
SEM1RAD23ABioGRID, MINT19013454 24811749 details
SEM1RAD23BBioGRID, MINT24811749 28396413 details
SEM1PSMD10BioGRID, MINT16239144 24811749 details
SEM1ADRM1BioGRID, MINT24811749 28396413 details
SEM1UCHL5BioGRID, MINT24811749 28396413 details
SEM1PSMD4BioGRID, DIP15610744 16239144 28396413 30479383 details
SEM1PSMD11BioGRID, DIP15610744 16239144 18775730 24515614 27342858 28396413 details
SEM1PSMD1BioGRID15610744 16239144 18775730 details
SEM1PSMD2BioGRID15610744 16239144 18775730 details
SEM1PSMD7BioGRID16239144 18775730 details
SEM1PSMD8BioGRID16239144 18775730 details
SEM1PSMD12BioGRID16239144 18775730 details
SEM1PSMD13BioGRID15610744 16239144 18775730 details
SEM1PSMD14BioGRID16239144 17323924 18775730 28396413 details
SEM1PSMC1BioGRID15610744 16239144 18775730 details
SEM1PSMC3BioGRID16239144 28396413 details
SEM1PSMC5BioGRID15610744 16239144 details
SEM1PSMC6BioGRID15610744 16239144 details
SEM1POLR2BBioGRID16239144 details
SEM1INTS2BioGRID16239144 details
SEM1INTS4BioGRID16239144 details
SEM1INTS5BioGRID16239144 details
SEM1INTS6BioGRID16239144 details
SEM1INTS7BioGRID16239144 details
SEM1INTS8BioGRID16239144 details
SEM1INTS9BioGRID16239144 details
SEM1INTS10BioGRID16239144 details
SEM1INTS11BioGRID16239144 details
SEM1LENG8BioGRID16239144 details
SEM1PSMA7BioGRID18775730 details
SEM1PSMA6BioGRID18775730 details
SEM1PSMA2BioGRID18775730 details
SEM1PSMB1BioGRID18775730 details
SEM1PSMB4BioGRID18775730 details
SEM1PSMC4BioGRID15610744 details
SEM1PIAS1BioGRID24515614 details
SEM1TRIM33BioGRID24515614 details
SEM1HSPA8BioGRID24515614 details
SEM1EIF3ABioGRID24515614 details
SEM1EIF3CBioGRID24515614 details
SEM1EEF1A1BioGRID24515614 details
SEM1EEF1A2BioGRID24515614 details
SEM1EEF1GBioGRID24515614 details
SEM1EEF2BioGRID24515614 details
SEM1DDX42BioGRID24515614 details
SEM1MDN1BioGRID24515614 details
SEM1RPF2BioGRID24515614 details
SEM1TAF2BioGRID24515614 details
SEM1YY1BioGRID24515614 details
SEM1TOP1BioGRID24515614 details
SEM1SIN3ABioGRID24515614 details
SEM1SND1BioGRID24515614 details
SEM1HNRNPUBioGRID24515614 details
SEM1RBM15BBioGRID24515614 details
SEM1RBM33BioGRID24515614 details
SEM1ATXN2BioGRID24515614 details
SEM1PRPF4BBioGRID24515614 details
SEM1DNAI3BioGRID24515614 details
SEM1NARFBioGRID24515614 details
SEM1FEN1BioGRID24515614 details
SEM1CCDC39BioGRID24515614 details
SEM1CKAP5BioGRID24515614 details
SEM1DNAH6BioGRID24515614 details
SEM1TLN2BioGRID24515614 details
SEM1TXNRD1BioGRID24515614 details
SEM1HUWE1BioGRID, MINT24811749 details
SEM1UBQLN2BioGRID, MINT24811749 details
SEM1UBR4BioGRID, MINT24811749 details
SEM1UBE3ABioGRID, MINT24811749 details
SEM1RNF181BioGRID, MINT24811749 details
SEM1PSMG3BioGRID, MINT24811749 details
SEM1UBE3BBioGRID, MINT24811749 details
SEM1NEDD8BioGRID, MINT24811749 details
SEM1UBR5BioGRID, MINT24811749 details
SEM1UFD1BioGRID, MINT24811749 details
SEM1FBXO7BioGRID, MINT24811749 details
SEM1TXNL1BioGRID, MINT24811749 details
SEM1UBR7BioGRID, MINT24811749 details
SEM1USP7BioGRID, MINT24811749 details
SEM1LTN1BioGRID, MINT24811749 details
SEM1PSMG2BioGRID, MINT24811749 details
SEM1PRRC2ABioGRID, MINT24811749 details
SEM1UBQLN4BioGRID, MINT24811749 details
SEM1PSME1BioGRID, MINT24811749 details
SEM1NUB1BioGRID, MINT24811749 details
SEM1UBCBioGRID, MINT24811749 details
SEM1MARCHF6BioGRID, MINT24811749 details
SEM1NSFL1CBioGRID, MINT24811749 details
SEM1CUL4BBioGRID, MINT24811749 details
SEM1BAG6BioGRID, MINT24811749 details
SEM1ZFAND2BBioGRID, MINT24811749 details
SEM1UBE2G2BioGRID, MINT24811749 details
SEM1PAAF1BioGRID, MINT24811749 details
SEM1UBLCP1BioGRID, MINT24811749 details
SEM1PSME3BioGRID, MINT24811749 details
SEM1RNF126BioGRID, MINT24811749 details
SEM1DDX39BBioGRID, MINT24811749 details
SEM1UBA7BioGRID, MINT24811749 details
SEM1UBR1BioGRID, MINT24811749 details
SEM1UBL4ABioGRID, MINT24811749 details
SEM1UBFD1BioGRID, MINT24811749 details
SEM1CUL2BioGRID, MINT24811749 details
SEM1SUMO2BioGRID, MINT24811749 details
SEM1USP15BioGRID, MINT24811749 details
SEM1PSME4BioGRID, MINT24811749 details
SEM1POMPBioGRID, MINT24811749 details
SEM1BAG2BioGRID, MINT24811749 details
SEM1OBI1BioGRID, MINT24811749 details
SEM1UBE2IBioGRID, MINT24811749 details
SEM1HECTD1BioGRID, MINT24811749 details
SEM1VCPBioGRID, MINT24811749 details
SEM1CUL1BioGRID, MINT24811749 details
SEM1USP38BioGRID, MINT24811749 details
SEM1PSMF1BioGRID, MINT24811749 details
SEM1PRRC2CBioGRID, MINT24811749 details
SEM1PSMD9BioGRID, MINT24811749 details
SEM1PSME2BioGRID, MINT24811749 details
SEM1PSMG1BioGRID, MINT24811749 details
SEM1UBQLN1BioGRID, MINT24811749 details
SEM1STUB1BioGRID, MINT24811749 details
SEM1BAG1BioGRID, MINT24811749 details
SEM1MCM3APDIP22343721 details
SEM1BAG3BioGRID23824909 details
SEM1DDX58BioGRID32513696 details