Entity Details

Primary name IRS2
Entity type gene
Source Source Link

Details

PrimaryID8660
RefseqGeneNG_008154
SymbolIRS2
Nameinsulin receptor substrate 2
Chromosome13
Location13q34
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-25
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsIRS2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002903 negative regulation of B cell apoptotic process
GO:0005158 insulin receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006006 glucose metabolic process
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010907 positive regulation of glucose metabolic process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019216 regulation of lipid metabolic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0019904 protein domain specific binding
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0030890 positive regulation of B cell proliferation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032024 positive regulation of insulin secretion
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0033673 negative regulation of kinase activity
GO:0038111 interleukin-7-mediated signaling pathway
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0055088 lipid homeostasis
GO:0071333 cellular response to glucose stimulus
GO:0071889 14-3-3 protein binding

Diseases

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Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
IRS2IGF1RHPRD, MINT8662806 9852124 details
IRS2INSRBioGRID, HPRD, MINT8626379 8662806 9195949 details
IRS2YWHAQBioGRID, IntAct15161933 17353931 28514442 details
IRS2GRB2BioGRID, HPRD, IntAct21706016 22974441 7559579 9852124 details
IRS2SIRT1BioGRID, UniProt17901049 21241768 details
IRS2PIK3R1BioGRID, HPRD, IntAct, MINT, UniProt11438664 12107746 12506011 15514089 19561084 21241768 23439647 23617393 26496610 8910607 9334184 9852124 details
IRS2PCNAUniProt26030842 details
IRS2PLCG1BioGRID, HPRD22974441 9535722 details
IRS2TYK2BioGRID, HPRD8550573 details
IRS2RPTORBioGRID19561084 details
IRS2NTRK1BioGRID, HPRD11147812 25921289 details
IRS2SRPK2BioGRID26167880 details
IRS2NEDD4BioGRID25879670 details
IRS2YWHAEBioGRID, HPRD, MINT17979178 9312143 details
IRS2YWHAZBioGRID, HPRD, IntAct, MINT15161933 26496610 28514442 9312143 details
IRS2SFNBioGRID, MINT15778465 details
IRS2PIK3R3BioGRID, HPRD, IntAct10417350 28514442 details
IRS2SOCS1BioGRID, HPRD12228220 27507812 29991678 details
IRS2PTPN11BioGRID, HPRD8910607 details
IRS2EPORBioGRID, HPRD9334184 details
IRS2BCL2BioGRID10679027 details
IRS2JAK1BioGRID, HPRD7499365 details
IRS2NISCHBioGRID11912194 details
IRS2IRS1BioGRID12554758 details
IRS2UBTFBioGRID, HPRD12554758 details
IRS2ESR1BioGRID12821935 details
IRS2GRB10BioGRID12783867 27742835 details
IRS2PIK3CABioGRID, HPRD12933652 25879670 9113989 details
IRS2SOCS3BioGRID, HPRD15514089 details
IRS2DVL2BioGRID24616100 details
IRS2EPN1BioGRID25879670 details
IRS2USP15BioGRID28126338 details
IRS2USP7BioGRID28126338 details
IRS2MTORBioGRID27742835 details
IRS2RPS6KB1BioGRID27742835 details
IRS2SH2B1BioGRID15316008 details
IRS2USP9XBioGRID30338032 details
IRS2PTPRFHPRD15588985 8732688 details
IRS2ATP2A1HPRD9295312 details
IRS2BCL2L1HPRD10679027 details
IRS2JAK3HPRD7499365 details
IRS2SHC1HPRD11505033 details
IRS2SOCS6HPRD12052866 details
IRS2JAK2HPRD12960006 details
IRS2PTPN6HPRD12198247 details
IRS2ATP2A2HPRD9295312 details
IRS2MPLHPRD11054408 details
IRS2CRKHPRD8621590 details
IRS2FESHPRD10856136 details
IRS2PIK3R2HPRD10594015 9651378 details
IRS2SOCS7HPRD12052866 details
IRS2IL4RHPRD8954948 details
IRS2YWHAGBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
IRS2YWHABBioGRID, HPRD, IntAct, MINT15324660 17353931 24255178 28514442 details
IRS2YWHAHBioGRID, IntAct17979178 26496610 28514442 details
IRS2EGLN3BioGRID, IntAct26972000 details
IRS2NETO2BioGRID, IntAct26496610 details
IRS2MRPL1BioGRID, IntAct26496610 details
IRS2EGFRBioGRID18271526 details
IRS2COPS2BioGRID22939629 details
IRS2FBXW11BioGRID25900982 details
IRS2XPO1BioGRID26673895 details
IRS2EFTUD2BioGRID28515276 details
IRS2MTMR4BioGRID28675297 details
IRS2PLK1BioGRID25659891 details
IRS2PPP1CABioGRID29669786 details
IRS2NHLRC2BioGRID30397336 details
IRS2BRPF3BioGRID31753913 details
IRS2TRIM66BioGRID31753913 details
IRS2NR3C1BioGRID31182584 details
IRS2EZRBioGRID34079125 details
IRS2RHOBBioGRID34079125 details
IRS2VASPBioGRID34079125 details
IRS2FOXO3IntAct27451907 details
IRS2ELAVL1BioGRID19322201 details
IRS2VIRMABioGRID29507755 details
IRS2MTDHBioGRID22199357 details
IRS2HNRNPH1BioGRID26760575 details
IRS2MKRN2BioGRID32460013 details