Entity Details

Primary name STAG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8N3U4
EntryNameSTAG2_HUMAN
FullNameCohesin subunit SA-2
TaxID9606
Evidenceevidence at protein level
Length1231
SequenceStatuscomplete
DateCreated2003-03-25
DateModified2021-06-02

Ontological Relatives

GenesSTAG2

GO terms

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GOName
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0007062 sister chromatid cohesion
GO:0008278 cohesin complex
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0090307 mitotic spindle assembly
GO:0097431 mitotic spindle pole

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR013721 STAGDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR020839 Stromalin conservative domainDomainDomain
IPR039662 Cohesin subunit Scc3/SAFamilyFamily

Diseases

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Disease IDSourceNameDescription
301043 OMIMHoloprosencephaly 13, X-linked (HPE13)An X-linked form of holoprosencephaly, a structural anomaly of the brain in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. HPE13 features range from full alobar holoprosencephaly with cyclopia to semilobar holoprosencephaly or septooptic dysplasia. Dysmorphic features include microcephaly, hypotelorism, low-set ears, micrognathia, and cleft lip/palate. Patients with a more severe phenotype may die in the newborn period, whereas those with a less severe phenotype show global developmental delay. The disease is caused by variants affecting the gene represented in this entry.
301022 OMIMMullegama-Klein-Martinez syndrome (MKMS)An X-linked neurodevelopmental disorder with variable features including intellectual deficiency, microcephaly, microtia, hearing loss, developmental delay, dysmorphic features, language delay, congenital heart defect, and clinodactyly of the 5th finger. The disease is caused by variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
STAG2_HUMANRAD21_HUMANBioGRID, DIP, HPRD, IntAct, MINT10931856 11590136 12034751 15737063 17113138 17962804 19629043 20818333 21043528 22145905 22751501 22885700 24981860 25173175 26344197 26496610 28514442 29263825 29867216 31010829 details
STAG2_HUMANSSU72_HUMANBioGRID, MINT20818333 details
STAG2_HUMANITBP2_HUMANBioGRID, IntAct23414517 details
STAG2_HUMANPCNA_HUMANUniProt26030842 details
STAG2_HUMANPLK1_HUMANBioGRID15737063 details
STAG2_HUMANPTEN_HUMANBioGRID31685992 details
STAG2_HUMANSUMO2_HUMANBioGRID32786267 details
STAG2_HUMANMYC_HUMANIntAct17353931 details
STAG2_HUMANWAPL_HUMANBioGRID, DIP, IntAct, MINT, UniProt17112726 17113138 20360068 25173175 26496610 29263825 29867216 31010829 details
STAG2_HUMANSMC3_HUMANBioGRID, DIP, IntAct, MINT, UniProt10931856 15737063 15855230 17113138 17349791 17962804 18235444 19629043 22885700 24981860 26344197 26496610 29263825 29867216 31010829 details
STAG2_HUMANPDS5B_HUMANBioGRID, DIP, IntAct, UniProt15855230 17113138 29867216 31010829 details
STAG2_HUMANSMC1A_HUMANBioGRID, DIP, IntAct, MINT, UniProt10931856 17112726 17113138 19629043 23242214 24981860 26344197 26496610 29263825 29867216 31010829 details
STAG2_HUMANPDS5A_HUMANBioGRID, DIP, IntAct, MINT, UniProt11076961 15855230 17113138 26344197 29263825 29867216 31010829 details
STAG2_HUMANSTAG1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11076961 17962804 24981860 29867216 30021884 31010829 details
STAG2_HUMANCDCA5_HUMANBioGRID, IntAct, MINT21987589 26186194 26496610 28514442 29263825 31010829 details
STAG2_HUMANSGO1_HUMANDIP, MINT23242214 25173175 29263825 details
STAG2_HUMANSRRM1_HUMANBioGRID16159877 details
STAG2_HUMANWFDC5_HUMANBioGRID17112726 details
STAG2_HUMANNSE2_HUMANBioGRID22751501 details
STAG2_HUMANU5S1_HUMANBioGRID28515276 31010829 details
STAG2_HUMANNIPBL_HUMANBioGRID31010829 details
STAG2_HUMANSCC4_HUMANBioGRID31010829 details
STAG2_HUMANDSRAD_HUMANBioGRID31010829 details
STAG2_HUMANRRP5_HUMANBioGRID31010829 details
STAG2_HUMANU520_HUMANBioGRID31010829 details
STAG2_HUMANRBM15_HUMANBioGRID31010829 details
STAG2_HUMANHSP7C_HUMANBioGRID31010829 details
STAG2_HUMANHNRH1_HUMANBioGRID31010829 details
STAG2_HUMANSF3B1_HUMANBioGRID31010829 details
STAG2_HUMANSF3B3_HUMANBioGRID31010829 details
STAG2_HUMANPRP31_HUMANBioGRID31010829 details
STAG2_HUMANDDX47_HUMANBioGRID31010829 details