Entity Details

Primary name HTRA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92743
EntryNameHTRA1_HUMAN
FullNameSerine protease HTRA1
TaxID9606
Evidenceevidence at protein level
Length480
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesHTRA1

GO terms

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GOName
GO:0001890 placenta development
GO:0004252 serine-type endopeptidase activity
GO:0005520 insulin-like growth factor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0008236 serine-type peptidase activity
GO:0022617 extracellular matrix disassembly
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0042802 identical protein binding
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050687 negative regulation of defense response to virus
GO:0060718 chorionic trophoblast cell differentiation
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0097187 dentinogenesis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000867 Insulin-like growth factor-binding protein, IGFBPDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001940 Peptidase S1CFamilyFamily
IPR002350 Kazal domainDomainDomain
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

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Disease IDSourceNameDescription
600142 OMIMCerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy (CARASIL)A cerebrovascular disease characterized by non-hypertensive arteriopathy of cerebral small vessels with subcortical infarcts, alopecia, and spondylosis. Small cerebral arteries show arteriosclerotic changes, fibrous intimal proliferation, and hyaline degeneration with splitting of the intima and/or the internal elastic membrane. Neurologic features include progressive dementia, gait disturbances, extrapyramidal and pyramidal signs, and demyelination of the cerebral white matter with sparing of U fibers. The disease is caused by variants affecting the gene represented in this entry.
616779 OMIMCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, 2 (CADASIL2)A cerebrovascular disease characterized by multiple subcortical infarcts, pseudobulbar palsy, dementia, and the presence of granular deposits in small cerebral arteries producing ischemic stroke. The disease is caused by variants affecting the gene represented in this entry.
610149 OMIMMacular degeneration, age-related, 7 (ARMD7)A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
HTRA1_HUMANNOS3_HUMANBioGRID, IntAct21163940 details
HTRA1_HUMANCSK2B_HUMANBioGRID, IntAct21988832 details
HTRA1_HUMANIMDH1_HUMANBioGRID, IntAct21988832 details
HTRA1_HUMANHTRA1_HUMANBioGRID, DIP, IntAct21297635 22578544 28642151 details
HTRA1_HUMANTAU_HUMANBioGRID, DIP22535953 26436840 details
HTRA1_HUMANCDC42_HUMANIntAct21311754 details
HTRA1_HUMANMIF_HUMANIntAct28726057 details
HTRA1_HUMANHTRA4_HUMANIntAct25002585 details
HTRA1_HUMANATS7_HUMANIntAct21622153 details
HTRA1_HUMANCTND2_HUMANIntAct21622153 details
HTRA1_HUMANTBB2A_HUMANIntAct21622153 details
HTRA1_HUMANCO1A1_HUMANHPRD, IntAct15101818 21622153 details
HTRA1_HUMANFBLN1_HUMANIntAct21622153 details
HTRA1_HUMANCOX2_HUMANIntAct21622153 details
HTRA1_HUMANDYLT3_HUMANIntAct21622153 details
HTRA1_HUMANWAC_HUMANIntAct21622153 details
HTRA1_HUMANEIF3F_HUMANIntAct21622153 details
HTRA1_HUMANTSC2_HUMANIntAct21622153 details
HTRA1_HUMANB4GN4_HUMANIntAct21622153 details
HTRA1_HUMANLZTS2_HUMANIntAct21622153 details
HTRA1_HUMANXIAP_HUMANBioGRID, IntAct21387310 28642151 details
HTRA1_HUMANAPOE_HUMANBioGRID21163940 details
HTRA1_HUMANTET5A_HUMANBioGRID, HPRD15231748 details
HTRA1_HUMANF107A_HUMANBioGRID28604741 details
HTRA1_HUMANKS6A1_HUMANBioGRID30726710 details
HTRA1_HUMANLTBP1_HUMANBioGRID25369932 details
HTRA1_HUMANLRP10_HUMANHPRD15101818 details
HTRA1_HUMANICAL_HUMANHPRD15101818 details
HTRA1_HUMANFCSD2_HUMANHPRD15101818 details
HTRA1_HUMANGOGA2_HUMANHPRD15101818 details
HTRA1_HUMANPAR6B_HUMANHPRD15101818 details
HTRA1_HUMANCDYL_HUMANHPRD15101818 details
HTRA1_HUMANCOX5A_HUMANHPRD15101818 details
HTRA1_HUMANCO3A1_HUMANHPRD15101818 details
HTRA1_HUMANCO2A1_HUMANHPRD15101818 details
HTRA1_HUMANTSP1_HUMANIntAct29572155 details
HTRA1_HUMANJAG1_HUMANIntAct29713059 details
HTRA1_HUMANBMP4_HUMANHPRD14973287 details
HTRA1_HUMANGDF5_HUMANHPRD14973287 details