Entity Details

Primary name REQU_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92785
EntryNameREQU_HUMAN
FullNameZinc finger protein ubi-d4
TaxID9606
Evidenceevidence at protein level
Length391
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDPF2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0003712 transcription coregulator activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006915 apoptotic process
GO:0007399 nervous system development
GO:0042393 histone binding
GO:0043231 intracellular membrane-bounded organelle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0062072 H3K9me3 modified histone binding
GO:0070577 lysine-acetylated histone binding
GO:0071565 nBAF complex
GO:0097190 apoptotic signaling pathway
GO:1905454 negative regulation of myeloid progenitor cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR025750 Requiem/DPF N-terminal domainDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618027 OMIMCoffin-Siris syndrome 7 (CSS7)A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported. CSS7 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
REQU_HUMANRELB_HUMANBioGRID, HPRD, IntAct14743216 20460684 details
REQU_HUMANFHL2_HUMANBioGRID, IntAct18255255 details
REQU_HUMANZN212_HUMANBioGRID, IntAct18255255 details
REQU_HUMANSMCA4_HUMANBioGRID, IntAct, MINT20460684 22334708 23540691 24981860 26186194 26344197 28514442 28533407 30962207 31043422 details
REQU_HUMANLDOC1_HUMANBioGRID, IntAct25416956 32296183 details
REQU_HUMANLNX1_HUMANBioGRID, IntAct25416956 details
REQU_HUMANRUBIC_HUMANBioGRID, IntAct32296183 details
REQU_HUMANRINT1_HUMANBioGRID, IntAct32296183 details
REQU_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
REQU_HUMANTXD12_HUMANBioGRID, IntAct32296183 details
REQU_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
REQU_HUMANZN655_HUMANBioGRID, IntAct32296183 details
REQU_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
REQU_HUMANTT23L_HUMANBioGRID, IntAct32296183 details
REQU_HUMANSMRD1_HUMANBioGRID, IntAct, MINT20305087 20460684 24981860 26186194 26344197 28514442 28533407 details
REQU_HUMANSNF5_HUMANBioGRID, IntAct, MINT20460684 24981860 26186194 26344197 28514442 28533407 30108113 31759698 details
REQU_HUMANSMCA2_HUMANBioGRID, IntAct, MINT20460684 22334708 24981860 26186194 26344197 28514442 31753913 details
REQU_HUMANTF65_HUMANBioGRID, IntAct20460684 22334708 details
REQU_HUMANREL_HUMANBioGRID20460684 details
REQU_HUMANNFKB1_HUMANBioGRID20460684 22334708 details
REQU_HUMANNFKB2_HUMANBioGRID20460684 details
REQU_HUMANH31T_HUMANBioGRID23281010 details
REQU_HUMANRENT2_HUMANBioGRID15231747 details
REQU_HUMANH31_HUMANBioGRID27775714 28533407 29429572 details
REQU_HUMANH4_HUMANBioGRID28533407 29429572 details
REQU_HUMANMEOX2_HUMANBioGRID32296183 details
REQU_HUMANBCL7C_HUMANBioGRID, IntAct, MINT18809673 24981860 26186194 26344197 28514442 details
REQU_HUMANSMCE1_HUMANBioGRID, IntAct, MINT18809673 20305087 24981860 26186194 26344197 28514442 details
REQU_HUMANSMRC1_HUMANBioGRID, IntAct, MINT20460684 22334708 24981860 26186194 26344197 28514442 28533407 29374058 details
REQU_HUMANSMRC2_HUMANBioGRID, IntAct, MINT20305087 24981860 26186194 26344197 28514442 28533407 details
REQU_HUMANACL6A_HUMANBioGRID, IntAct, MINT24981860 26186194 28514442 28533407 29374058 details
REQU_HUMANBAF_HUMANBioGRID19759913 details
REQU_HUMANANDR_HUMANBioGRID28611094 details
REQU_HUMANRUNX1_HUMANBioGRID28533407 details
REQU_HUMANHDAC6_HUMANBioGRID29278704 details