Entity Details

Primary name HXB13_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92826
EntryNameHXB13_HUMAN
FullNameHomeobox protein Hox-B13
TaxID9606
Evidenceevidence at protein level
Length284
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHOXB13

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008327 methyl-CpG binding
GO:0008544 epidermis development
GO:0009611 response to wounding
GO:0033574 response to testosterone
GO:0040008 regulation of growth
GO:0043565 sequence-specific DNA binding
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR022067 Homeobox protein Hox1A3 N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
176807 OMIMProstate cancer (PC)A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Disease susceptibility is associated with variants affecting the gene represented in this entry.