Entity Details

Primary name LITAF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99732
EntryNameLITAF_HUMAN
FullNameLipopolysaccharide-induced tumor necrosis factor-alpha factor
TaxID9606
Evidenceevidence at protein level
Length161
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesLITAF

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001817 regulation of cytokine production
GO:0005654 nucleoplasm
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007568 aging
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050699 WW domain binding
GO:0071222 cellular response to lipopolysaccharide
GO:0098559 cytoplasmic side of early endosome membrane
GO:0098560 cytoplasmic side of late endosome membrane
GO:0098574 cytoplasmic side of lysosomal membrane
GO:1901223 negative regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome membrane
Endosome membrane
Golgi apparatus membrane
Late endosome membrane
Lysosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR006629 LPS-induced tumour necrosis factor alpha factorDomainDomain
IPR037519 LITAF domain containing proteinFamilyFamily

Diseases

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Disease IDSourceNameDescription
601098 OMIMCharcot-Marie-Tooth disease 1C (CMT1C)A dominant demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. The disease is caused by variants affecting the gene represented in this entry.

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
LITAF_HUMANCOMT_HUMANHPRD, IntAct16169070 details
LITAF_HUMANWWOX_HUMANBioGRID, IntAct15064722 32296183 details
LITAF_HUMANATX1_HUMANBioGRID, IntAct23275563 details
LITAF_HUMANBAG3_HUMANBioGRID, IntAct23824909 25416956 31515488 32296183 details
LITAF_HUMANHGS_HUMANBioGRID, IntAct25416956 25910212 31515488 details
LITAF_HUMANSTAM2_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
LITAF_HUMANCACO2_HUMANBioGRID, IntAct25416956 25910212 details
LITAF_HUMANREEP6_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
LITAF_HUMANUBQL1_HUMANBioGRID, IntAct25416956 25910212 details
LITAF_HUMANHIP1_HUMANBioGRID, IntAct32296183 32814053 details
LITAF_HUMANDAZP2_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANTAXB1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANEPN2_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANN4BP1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANRL40_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANKCIP4_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANRS27A_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANVENTX_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANCREB5_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANRASF3_HUMANBioGRID, IntAct28514442 32296183 details
LITAF_HUMANHPCL4_HUMANBioGRID, IntAct28514442 32296183 details
LITAF_HUMANNCALD_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANHPCL1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANTOM1_HUMANBioGRID, IntAct25963657 32296183 details
LITAF_HUMANTNIP1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANGGA3_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANUBQL2_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANEPN1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANVISL1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANARI5A_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANKCIP1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANTNIP3_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANZIC1_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANPOGZ_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANRN208_HUMANBioGRID, IntAct32296183 details
LITAF_HUMANOPTN_HUMANBioGRID, IntAct25910212 32814053 details
LITAF_HUMANLAMP2_HUMANIntAct32814053 details
LITAF_HUMANRASF1_HUMANIntAct32814053 details
LITAF_HUMANCAN10_HUMANIntAct32814053 details
LITAF_HUMANWWP2_HUMANBioGRID, IntAct25963657 32814053 details
LITAF_HUMANCBX1_HUMANIntAct32814053 details
LITAF_HUMANBASP1_HUMANIntAct32814053 details
LITAF_HUMANUB2L6_HUMANIntAct32814053 details
LITAF_HUMANDDX21_HUMANIntAct32814053 details
LITAF_HUMANCOR2A_HUMANIntAct32814053 details
LITAF_HUMANSMAD5_HUMANIntAct32814053 details
LITAF_HUMANDOCK2_HUMANIntAct32814053 details
LITAF_HUMANAKA11_HUMANIntAct32814053 details
LITAF_HUMANRN152_HUMANIntAct32814053 details
LITAF_HUMANSAMD3_HUMANIntAct32814053 details
LITAF_HUMANRN183_HUMANIntAct32814053 details
LITAF_HUMANIMP2L_HUMANIntAct32814053 details
LITAF_HUMANSRCN1_HUMANIntAct32814053 details
LITAF_HUMANPPL13_HUMANIntAct32814053 details
LITAF_HUMANT176A_HUMANIntAct32814053 details
LITAF_HUMANCDCA4_HUMANIntAct32814053 details
LITAF_HUMANRM04_HUMANIntAct32814053 details
LITAF_HUMANVILL_HUMANIntAct32814053 details
LITAF_HUMANDAPP1_HUMANIntAct32814053 details
LITAF_HUMANCOQ8A_HUMANIntAct32814053 details
LITAF_HUMANITCH_HUMANBioGRID21326863 25963657 details
LITAF_HUMANSTAT6_HUMANBioGRID15793005 details
LITAF_HUMANEPN3_HUMANBioGRID32296183 details
LITAF_HUMANRADIL_HUMANHPRD16169070 details
LITAF_HUMANSMAD2_HUMANHPRD15231748 details
LITAF_HUMANNEDD4_HUMANBioGRID, HPRD, IntAct11042109 16118794 25963657 28514442 details
LITAF_HUMANTS101_HUMANBioGRID, IntAct16118794 25963657 details
LITAF_HUMANNED4L_HUMANBioGRID, IntAct25963657 28514442 details
LITAF_HUMANWWP1_HUMANBioGRID25963657 details
LITAF_HUMANTAB2_HUMANBioGRID25963657 details
LITAF_HUMANBCL6_HUMANBioGRID27764808 details
LITAF_HUMANCACB3_HUMANBioGRID31462068 details
LITAF_HUMANCAC1C_HUMANBioGRID31462068 details