Entity Details

Primary name MYD88_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99836
EntryNameMYD88_HUMAN
FullNameMyeloid differentiation primary response protein MyD88
TaxID9606
Evidenceevidence at protein level
Length296
SequenceStatuscomplete
DateCreated2001-10-18
DateModified2021-06-02

Ontological Relatives

GenesMYD88

GO terms

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GOName
GO:0002224 toll-like receptor signaling pathway
GO:0002238 response to molecule of fungal origin
GO:0002269 leukocyte activation involved in inflammatory response
GO:0002283 neutrophil activation involved in immune response
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005121 Toll binding
GO:0005123 death receptor binding
GO:0005149 interleukin-1 receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0009615 response to virus
GO:0009682 induced systemic resistance
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0014069 postsynaptic density
GO:0016064 immunoglobulin mediated immune response
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032481 positive regulation of type I interferon production
GO:0032494 response to peptidoglycan
GO:0032722 positive regulation of chemokine production
GO:0032740 positive regulation of interleukin-17 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0034162 toll-like receptor 9 signaling pathway
GO:0035325 Toll-like receptor binding
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043621 protein self-association
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050727 regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060337 type I interferon signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0070944 neutrophil-mediated killing of bacterium
GO:0070976 TIR domain binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0090557 establishment of endothelial intestinal barrier
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1902622 regulation of neutrophil migration
GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000488 Death domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR017281 Myeloid differentiation primary response protein MyD88FamilyFamily
IPR034249 MyD88, death domainDomainDomain
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612260 OMIMImmunodeficiency 68 (IMD68)An autosomal recessive primary immunodeficiency characterized by life-threatening, often recurrent, pyogenic bacterial infections, including invasive pneumococcal disease, beginning in infancy or early childhood. The disease is caused by variants affecting the gene represented in this entry.

Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
MYD88_HUMANIRAK4_HUMANBioGRID, DIP, HPRD, IntAct11960013 12538665 12860405 17548806 18221795 20485341 22011580 24316379 24735611 25416956 25502805 25910212 26871637 31515488 32296183 details
MYD88_HUMANFADD_HUMANBioGRID, HPRD, IntAct10880445 11828002 21988832 details
MYD88_HUMANTIRAP_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt11544529 17258210 17583698 18221795 20048342 21334391 24316379 28483816 details
MYD88_HUMANMYD88_HUMANBioGRID, DIP, HPIDb, HPRD, IntAct, MINT11544529 11909531 17258210 17548806 21516116 21988832 22155231 24316379 25416956 25910212 27107012 29892012 31930677 32296183 9575168 details
MYD88_HUMANSPOP_HUMANBioGRID, HPRD, IntAct16189514 21988832 26186194 28514442 31776466 details
MYD88_HUMANTLR2_HUMANBioGRID, HPRD, IntAct, MINT, UniProt15107846 16293622 16482509 17126326 29990310 details
MYD88_HUMANTLR4_HUMANBioGRID, HPRD, IntAct, MINT10952994 11743586 12646618 15107846 15728506 17126326 17258210 18221795 20048342 21829704 21911421 33052227 details
MYD88_HUMANTLR5_HUMANBioGRID, HPRD, MINT15107846 16482509 17583698 details
MYD88_HUMANSTAP2_HUMANBioGRID, HPRD, IntAct16365431 details
MYD88_HUMANTR13B_HUMANBioGRID, InnateDB20676093 details
MYD88_HUMANMDM2_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANPRDX1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANPFKAL_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANMBIP1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANSMAD3_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANMAL_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANTHIO_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANSIAH2_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANSIAH1_HUMANBioGRID, IntAct21988832 32117091 details
MYD88_HUMANUBP7_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANRPAC1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANC1QR1_HUMANBioGRID, IntAct21988832 details
MYD88_HUMANTLR7_HUMANBioGRID, HPRD, IntAct16482509 21988832 details
MYD88_HUMANSARM1_HUMANBioGRID, IntAct17258210 26592460 details
MYD88_HUMANZNF35_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANSPOPL_HUMANBioGRID, IntAct32296183 details
MYD88_HUMANTLR9_HUMANBioGRID15107846 21911421 details
MYD88_HUMANTLR3_HUMANBioGRID, HPRD12646618 details
MYD88_HUMANRAC1_HUMANBioGRID11416133 details
MYD88_HUMANIRF7_HUMANBioGRID, HPRD15361868 16484229 details
MYD88_HUMANCISH_HUMANBioGRID16961462 details
MYD88_HUMANIRF5_HUMANBioGRID, HPRD15665823 details
MYD88_HUMANNEMO_HUMANBioGRID23986494 details
MYD88_HUMANRN152_HUMANBioGRID31930677 details
MYD88_HUMANPELI2_HUMANHPRD12860405 details
MYD88_HUMANTLR8_HUMANHPRD16482509 details
MYD88_HUMANIRAK3_HUMANBioGRID, HPRD, MINT10383454 details
MYD88_HUMANIRAK1_HUMANBioGRID, DIP, HPIDb, HPRD, MINT10383454 10854325 11544529 11960013 11976320 12538665 16024789 16461741 16951688 17276401 17548806 17567694 17920759 21179087 21903422 22011580 31776466 33052227 details
MYD88_HUMANIRAK2_HUMANBioGRID, DIP, HPRD, MINT10383454 12659850 20485341 22011580 9374458 details
MYD88_HUMANILRL1_HUMANBioGRID, HPRD, UniProt15004556 16286016 details
MYD88_HUMANTRAF6_HUMANBioGRID, InnateDB16517750 20676093 22011580 23381138 23831471 31243359 31268348 33052227 details
MYD88_HUMANDOCK8_HUMANInnateDB22581261 details
MYD88_HUMANFAK2_HUMANInnateDB22581261 details
MYD88_HUMANCYH2_HUMANBioGRID, DIP23143332 details
MYD88_HUMANTLR10_HUMANHPRD, IntAct15728506 details
MYD88_HUMANHDAC6_HUMANBioGRID, IntAct20837465 29281743 31268348 details
MYD88_HUMANIL1R1_HUMANBioGRID, HPRD10854325 12609980 12659850 22904187 24735611 9374458 9575168 details
MYD88_HUMANLRRF1_HUMANBioGRID19265123 details
MYD88_HUMANLRRF2_HUMANBioGRID19265123 details
MYD88_HUMANFLII_HUMANBioGRID, HPRD16424162 19265123 details
MYD88_HUMANSQSTM_HUMANBioGRID20837465 details
MYD88_HUMANCBLB_HUMANBioGRID20639876 details
MYD88_HUMANTNIP1_HUMANBioGRID22011580 details
MYD88_HUMANTRAF3_HUMANBioGRID22011580 details
MYD88_HUMANBTK_HUMANBioGRID, HPRD12724322 details
MYD88_HUMANPELI1_HUMANBioGRID16951688 details
MYD88_HUMANSMAD6_HUMANBioGRID21897371 details
MYD88_HUMANSMUF1_HUMANBioGRID21897371 details
MYD88_HUMANBST2_HUMANBioGRID23221546 details
MYD88_HUMANIKKE_HUMANBioGRID23453969 details
MYD88_HUMANSASH1_HUMANBioGRID23776175 details
MYD88_HUMANKSYK_HUMANBioGRID23962979 details
MYD88_HUMANIRF4_HUMANBioGRID, HPRD16236719 24670424 details
MYD88_HUMANCYLD_HUMANBioGRID26719415 details
MYD88_HUMANUBAP1_HUMANBioGRID28483816 details
MYD88_HUMANTS101_HUMANBioGRID28483816 details
MYD88_HUMANBCAP_HUMANBioGRID27909057 details
MYD88_HUMANATG5_HUMANBioGRID23831471 details
MYD88_HUMANBANK1_HUMANBioGRID31243359 details
MYD88_HUMANIL1AP_HUMANHPRD11880380 details