Entity Details

Primary name RTN4R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BZR6
EntryNameRTN4R_HUMAN
FullNameReticulon-4 receptor
TaxID9606
Evidenceevidence at protein level
Length473
SequenceStatuscomplete
DateCreated2002-11-25
DateModified2021-06-02

Ontological Relatives

GenesRTN4R

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0008201 heparin binding
GO:0009986 cell surface
GO:0010977 negative regulation of neuron projection development
GO:0022038 corpus callosum development
GO:0023041 neuronal signal transduction
GO:0030517 negative regulation of axon extension
GO:0031362 anchored component of external side of plasma membrane
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035374 chondroitin sulfate binding
GO:0038023 signaling receptor activity
GO:0038131 neuregulin receptor activity
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043547 positive regulation of GTPase activity
GO:0044295 axonal growth cone
GO:0045121 membrane raft
GO:0048681 negative regulation of axon regeneration
GO:0050771 negative regulation of axonogenesis
GO:0070062 extracellular exosome
GO:1905573 ganglioside GM1 binding
GO:1905576 ganglioside GT1b binding

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Membrane raft
Perikaryon

Domains

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DomainNameCategoryType
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
181500 OMIMSchizophrenia (SCZD)A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Disease susceptibility is associated with variants affecting the gene represented in this entry.