Entity Details

Primary name P4HA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15460
EntryNameP4HA2_HUMAN
FullNameProlyl 4-hydroxylase subunit alpha-2
TaxID9606
Evidenceevidence at protein level
Length535
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesP4HA2

GO terms

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GOName
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0009055 electron transfer activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0030199 collagen fibril organization
GO:0031418 L-ascorbic acid binding
GO:0043231 intracellular membrane-bounded organelle

Subcellular Location

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Subcellular Location
Endoplasmic reticulum lumen

Domains

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DomainNameCategoryType
IPR005123 Oxoglutarate/iron-dependent dioxygenaseDomainDomain
IPR006620 Prolyl 4-hydroxylase, alpha subunitDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminalDomainDomain
IPR019734 Tetratricopeptide repeatRepeatRepeat

Diseases

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Disease IDSourceNameDescription
617238 OMIMMyopia 25, autosomal dominant (MYP25)A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00139 Succinic acidDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule